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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMD8
Full Name:
26S proteasome non-ATPase regulatory subunit 8
Alias:
26S proteasome regulatory subunit p31; 26S proteasome regulatory subunit S14; HIP6; HYPF; MGC1660; Nin1p; p31; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; proteasome 26S non-ATPase subunit 8; PSD8; Rpn12; S14
Type:
Proteasome complex; Protease
Mass (Da):
30005
Number AA:
257
UniProt ID:
P48556
International Prot ID:
IPI00791437
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005838
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
K
G
E
W
N
R
K
S
P
N
L
S
K
C
G
Site 2
S17
N
R
K
S
P
N
L
S
K
C
G
E
E
L
G
Site 3
S62
L
E
I
G
A
Q
W
S
I
L
R
K
D
I
P
Site 4
S70
I
L
R
K
D
I
P
S
F
E
R
Y
M
A
Q
Site 5
Y74
D
I
P
S
F
E
R
Y
M
A
Q
L
K
C
Y
Site 6
Y82
M
A
Q
L
K
C
Y
Y
F
D
Y
K
E
Q
L
Site 7
Y85
L
K
C
Y
Y
F
D
Y
K
E
Q
L
P
E
S
Site 8
S92
Y
K
E
Q
L
P
E
S
A
Y
M
H
Q
L
L
Site 9
Y94
E
Q
L
P
E
S
A
Y
M
H
Q
L
L
G
L
Site 10
T129
L
P
A
K
D
I
Q
T
N
V
Y
I
K
H
P
Site 11
S138
V
Y
I
K
H
P
V
S
L
E
Q
Y
L
M
E
Site 12
Y142
H
P
V
S
L
E
Q
Y
L
M
E
G
S
Y
N
Site 13
Y148
Q
Y
L
M
E
G
S
Y
N
K
V
F
L
A
K
Site 14
T202
T
R
I
L
F
F
N
T
P
K
K
M
T
D
Y
Site 15
Y209
T
P
K
K
M
T
D
Y
A
K
K
R
G
W
V
Site 16
Y222
W
V
L
G
P
N
N
Y
Y
S
F
A
S
Q
Q
Site 17
Y223
V
L
G
P
N
N
Y
Y
S
F
A
S
Q
Q
Q
Site 18
S224
L
G
P
N
N
Y
Y
S
F
A
S
Q
Q
Q
K
Site 19
S227
N
N
Y
Y
S
F
A
S
Q
Q
Q
K
P
E
D
Site 20
T235
Q
Q
Q
K
P
E
D
T
T
I
P
S
T
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation