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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NES
Full Name:
Nestin
Alias:
FLJ21841; NEST
Type:
Cytoskeletal protein
Mass (Da):
177439
Number AA:
1621
UniProt ID:
P48681
International Prot ID:
IPI00010800
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
L
N
R
R
L
E
A
Y
L
A
R
V
K
A
L
Site 2
S47
L
G
G
L
R
A
Q
S
A
D
T
S
W
R
A
Site 3
S51
R
A
Q
S
A
D
T
S
W
R
A
H
A
D
D
Site 4
T105
L
R
L
A
R
E
R
T
T
E
E
V
A
R
N
Site 5
T106
R
L
A
R
E
R
T
T
E
E
V
A
R
N
R
Site 6
S128
C
A
R
A
W
L
S
S
Q
V
A
E
L
E
R
Site 7
Y193
W
R
G
A
V
R
G
Y
Q
E
R
V
A
H
M
Site 8
T257
W
Q
E
R
L
R
A
T
E
K
F
Q
L
A
V
Site 9
T304
L
E
V
A
T
Y
R
T
L
L
E
A
E
N
S
Site 10
S311
T
L
L
E
A
E
N
S
R
L
Q
T
P
G
G
Site 11
T315
A
E
N
S
R
L
Q
T
P
G
G
G
S
K
T
Site 12
S320
L
Q
T
P
G
G
G
S
K
T
S
L
S
F
Q
Site 13
T322
T
P
G
G
G
S
K
T
S
L
S
F
Q
D
P
Site 14
S323
P
G
G
G
S
K
T
S
L
S
F
Q
D
P
K
Site 15
S325
G
G
S
K
T
S
L
S
F
Q
D
P
K
L
E
Site 16
T338
L
E
L
Q
F
P
R
T
P
E
G
R
R
L
G
Site 17
S346
P
E
G
R
R
L
G
S
L
L
P
V
L
S
P
Site 18
S352
G
S
L
L
P
V
L
S
P
T
S
L
P
S
P
Site 19
T354
L
L
P
V
L
S
P
T
S
L
P
S
P
L
P
Site 20
S355
L
P
V
L
S
P
T
S
L
P
S
P
L
P
A
Site 21
S358
L
S
P
T
S
L
P
S
P
L
P
A
T
L
E
Site 22
T363
L
P
S
P
L
P
A
T
L
E
T
P
V
P
A
Site 23
T366
P
L
P
A
T
L
E
T
P
V
P
A
F
L
K
Site 24
T382
Q
E
F
L
Q
A
R
T
P
T
L
A
S
T
P
Site 25
T384
F
L
Q
A
R
T
P
T
L
A
S
T
P
I
P
Site 26
S387
A
R
T
P
T
L
A
S
T
P
I
P
P
T
P
Site 27
T388
R
T
P
T
L
A
S
T
P
I
P
P
T
P
Q
Site 28
T393
A
S
T
P
I
P
P
T
P
Q
A
P
S
P
A
Site 29
S398
P
P
T
P
Q
A
P
S
P
A
V
D
A
E
I
Site 30
S413
R
A
Q
D
A
P
L
S
L
L
Q
T
Q
G
G
Site 31
T417
A
P
L
S
L
L
Q
T
Q
G
G
R
K
Q
A
Site 32
S455
G
G
Q
R
Q
E
A
S
T
G
Q
S
P
E
D
Site 33
T456
G
Q
R
Q
E
A
S
T
G
Q
S
P
E
D
H
Site 34
S459
Q
E
A
S
T
G
Q
S
P
E
D
H
A
S
L
Site 35
S465
Q
S
P
E
D
H
A
S
L
A
P
P
L
S
P
Site 36
S471
A
S
L
A
P
P
L
S
P
D
H
S
S
L
E
Site 37
S475
P
P
L
S
P
D
H
S
S
L
E
A
K
D
G
Site 38
S476
P
L
S
P
D
H
S
S
L
E
A
K
D
G
E
Site 39
S484
L
E
A
K
D
G
E
S
G
G
S
R
V
F
S
Site 40
S487
K
D
G
E
S
G
G
S
R
V
F
S
I
C
R
Site 41
S491
S
G
G
S
R
V
F
S
I
C
R
G
E
G
E
Site 42
S537
N
R
K
E
I
Q
D
S
Q
V
P
L
E
K
E
Site 43
T545
Q
V
P
L
E
K
E
T
L
K
S
L
G
E
E
Site 44
S548
L
E
K
E
T
L
K
S
L
G
E
E
I
Q
E
Site 45
S556
L
G
E
E
I
Q
E
S
L
K
T
L
E
N
Q
Site 46
T559
E
I
Q
E
S
L
K
T
L
E
N
Q
S
H
E
Site 47
S564
L
K
T
L
E
N
Q
S
H
E
T
L
E
R
E
Site 48
S578
E
N
Q
E
C
P
R
S
L
E
E
D
L
E
T
Site 49
T585
S
L
E
E
D
L
E
T
L
K
S
L
E
K
E
Site 50
S588
E
D
L
E
T
L
K
S
L
E
K
E
N
K
E
Site 51
T622
K
P
T
G
K
E
D
T
Q
T
L
Q
S
L
Q
Site 52
T624
T
G
K
E
D
T
Q
T
L
Q
S
L
Q
K
E
Site 53
S638
E
N
Q
E
L
M
K
S
L
E
G
N
L
E
T
Site 54
T645
S
L
E
G
N
L
E
T
F
L
F
P
G
T
E
Site 55
T651
E
T
F
L
F
P
G
T
E
N
Q
E
L
V
S
Site 56
S659
E
N
Q
E
L
V
S
S
L
Q
E
N
L
E
S
Site 57
S666
S
L
Q
E
N
L
E
S
L
T
A
L
E
K
E
Site 58
S680
E
N
Q
E
P
L
R
S
P
E
V
G
D
E
E
Site 59
T693
E
E
A
L
R
P
L
T
K
E
N
Q
E
P
L
Site 60
S702
E
N
Q
E
P
L
R
S
L
E
D
E
N
K
E
Site 61
S713
E
N
K
E
A
F
R
S
L
E
K
E
N
Q
E
Site 62
T724
E
N
Q
E
P
L
K
T
L
E
E
E
D
Q
S
Site 63
S731
T
L
E
E
E
D
Q
S
I
V
R
P
L
E
T
Site 64
T738
S
I
V
R
P
L
E
T
E
N
H
K
S
L
R
Site 65
S743
L
E
T
E
N
H
K
S
L
R
S
L
E
E
Q
Site 66
S746
E
N
H
K
S
L
R
S
L
E
E
Q
D
Q
E
Site 67
T754
L
E
E
Q
D
Q
E
T
L
R
T
L
E
K
E
Site 68
T757
Q
D
Q
E
T
L
R
T
L
E
K
E
T
Q
Q
Site 69
S768
E
T
Q
Q
R
R
R
S
L
G
E
Q
D
Q
M
Site 70
T776
L
G
E
Q
D
Q
M
T
L
R
P
P
E
K
V
Site 71
S790
V
D
L
E
P
L
K
S
L
D
Q
E
I
A
R
Site 72
S809
E
N
Q
E
F
L
K
S
L
K
E
E
S
V
E
Site 73
S814
L
K
S
L
K
E
E
S
V
E
A
V
K
S
L
Site 74
S820
E
S
V
E
A
V
K
S
L
E
T
E
I
L
E
Site 75
T823
E
A
V
K
S
L
E
T
E
I
L
E
S
L
K
Site 76
S828
L
E
T
E
I
L
E
S
L
K
S
A
G
Q
E
Site 77
S831
E
I
L
E
S
L
K
S
A
G
Q
E
N
L
E
Site 78
T839
A
G
Q
E
N
L
E
T
L
K
S
P
E
T
Q
Site 79
S842
E
N
L
E
T
L
K
S
P
E
T
Q
A
P
L
Site 80
T845
E
T
L
K
S
P
E
T
Q
A
P
L
W
T
P
Site 81
T851
E
T
Q
A
P
L
W
T
P
E
E
I
N
Q
G
Site 82
S873
E
I
Q
E
P
L
E
S
V
E
V
N
Q
E
T
Site 83
T880
S
V
E
V
N
Q
E
T
F
R
L
L
E
E
E
Site 84
S891
L
E
E
E
N
Q
E
S
L
R
S
L
G
A
W
Site 85
S894
E
N
Q
E
S
L
R
S
L
G
A
W
N
L
E
Site 86
S905
W
N
L
E
N
L
R
S
P
E
E
V
D
K
E
Site 87
S913
P
E
E
V
D
K
E
S
Q
R
N
L
E
E
E
Site 88
Y928
E
N
L
G
K
G
E
Y
Q
E
S
L
R
S
L
Site 89
S931
G
K
G
E
Y
Q
E
S
L
R
S
L
E
E
E
Site 90
S934
E
Y
Q
E
S
L
R
S
L
E
E
E
G
Q
E
Site 91
S945
E
G
Q
E
L
P
Q
S
A
D
V
Q
R
W
E
Site 92
T954
D
V
Q
R
W
E
D
T
V
E
K
D
Q
E
L
Site 93
S965
D
Q
E
L
A
Q
E
S
P
P
G
M
A
G
V
Site 94
T1003
E
Q
G
E
L
N
A
T
E
E
V
W
I
P
G
Site 95
S1016
P
G
E
G
H
P
E
S
P
E
P
K
E
Q
R
Site 96
S1030
R
G
L
V
E
G
A
S
V
K
G
G
A
E
G
Site 97
S1079
A
P
G
G
D
Q
A
S
P
E
V
M
L
G
S
Site 98
S1086
S
P
E
V
M
L
G
S
E
P
A
M
G
E
S
Site 99
T1115
L
G
D
P
G
H
L
T
R
E
E
V
M
E
P
Site 100
S1155
G
G
L
G
T
E
F
S
E
L
P
G
K
S
R
Site 101
S1161
F
S
E
L
P
G
K
S
R
D
P
W
E
P
P
Site 102
S1175
P
R
E
G
R
E
E
S
E
A
E
A
P
R
G
Site 103
S1197
E
T
L
G
H
T
G
S
D
A
P
S
P
W
P
Site 104
S1201
H
T
G
S
D
A
P
S
P
W
P
L
G
S
E
Site 105
S1207
P
S
P
W
P
L
G
S
E
E
A
E
E
D
V
Site 106
S1220
D
V
P
P
V
L
V
S
P
S
P
T
Y
T
P
Site 107
T1224
V
L
V
S
P
S
P
T
Y
T
P
I
L
E
D
Site 108
T1226
V
S
P
S
P
T
Y
T
P
I
L
E
D
A
P
Site 109
S1242
P
Q
P
Q
A
E
G
S
Q
E
A
S
W
G
V
Site 110
S1246
A
E
G
S
Q
E
A
S
W
G
V
Q
G
R
A
Site 111
S1261
E
A
L
G
K
V
E
S
E
Q
E
E
L
G
S
Site 112
S1268
S
E
Q
E
E
L
G
S
G
E
I
P
E
G
P
Site 113
S1282
P
Q
E
E
G
E
E
S
R
E
E
S
E
E
D
Site 114
S1286
G
E
E
S
R
E
E
S
E
E
D
E
L
G
E
Site 115
T1294
E
E
D
E
L
G
E
T
L
P
D
S
T
P
L
Site 116
T1299
G
E
T
L
P
D
S
T
P
L
G
F
Y
L
R
Site 117
Y1304
D
S
T
P
L
G
F
Y
L
R
S
P
T
S
P
Site 118
S1307
P
L
G
F
Y
L
R
S
P
T
S
P
R
W
D
Site 119
T1309
G
F
Y
L
R
S
P
T
S
P
R
W
D
P
T
Site 120
S1310
F
Y
L
R
S
P
T
S
P
R
W
D
P
T
G
Site 121
T1316
T
S
P
R
W
D
P
T
G
E
Q
R
P
P
P
Site 122
S1347
E
G
L
E
A
P
P
S
E
K
E
E
G
E
E
Site 123
S1363
E
E
E
C
G
R
D
S
D
L
S
E
E
F
E
Site 124
S1366
C
G
R
D
S
D
L
S
E
E
F
E
D
L
G
Site 125
T1374
E
E
F
E
D
L
G
T
E
A
P
F
L
P
G
Site 126
S1409
A
W
D
R
D
G
E
S
D
G
F
A
D
E
E
Site 127
S1418
G
F
A
D
E
E
E
S
G
E
E
G
E
E
D
Site 128
S1441
A
G
R
W
G
P
G
S
S
V
G
S
L
Q
A
Site 129
S1442
G
R
W
G
P
G
S
S
V
G
S
L
Q
A
L
Site 130
S1445
G
P
G
S
S
V
G
S
L
Q
A
L
S
S
S
Site 131
S1450
V
G
S
L
Q
A
L
S
S
S
Q
R
G
E
F
Site 132
S1451
G
S
L
Q
A
L
S
S
S
Q
R
G
E
F
L
Site 133
S1452
S
L
Q
A
L
S
S
S
Q
R
G
E
F
L
E
Site 134
S1460
Q
R
G
E
F
L
E
S
D
S
V
S
V
S
V
Site 135
S1462
G
E
F
L
E
S
D
S
V
S
V
S
V
P
W
Site 136
S1464
F
L
E
S
D
S
V
S
V
S
V
P
W
D
D
Site 137
S1466
E
S
D
S
V
S
V
S
V
P
W
D
D
S
L
Site 138
T1483
A
V
A
G
A
P
K
T
A
L
E
T
E
S
Q
Site 139
S1489
K
T
A
L
E
T
E
S
Q
D
S
A
E
P
S
Site 140
S1492
L
E
T
E
S
Q
D
S
A
E
P
S
G
S
E
Site 141
S1496
S
Q
D
S
A
E
P
S
G
S
E
E
E
S
D
Site 142
S1498
D
S
A
E
P
S
G
S
E
E
E
S
D
P
V
Site 143
S1502
P
S
G
S
E
E
E
S
D
P
V
S
L
E
R
Site 144
S1506
E
E
E
S
D
P
V
S
L
E
R
E
D
K
V
Site 145
S1521
P
G
P
L
E
I
P
S
G
M
E
D
A
G
P
Site 146
S1546
G
P
N
L
E
G
K
S
Q
H
V
N
G
G
V
Site 147
S1560
V
M
N
G
L
E
Q
S
E
E
V
G
Q
G
M
Site 148
S1571
G
Q
G
M
P
L
V
S
E
G
D
R
G
S
P
Site 149
S1577
V
S
E
G
D
R
G
S
P
F
Q
E
E
E
G
Site 150
S1585
P
F
Q
E
E
E
G
S
A
L
K
T
S
W
A
Site 151
T1589
E
E
G
S
A
L
K
T
S
W
A
G
A
P
V
Site 152
S1590
E
G
S
A
L
K
T
S
W
A
G
A
P
V
H
Site 153
T1607
Q
G
Q
F
L
K
F
T
Q
R
E
G
D
R
E
Site 154
S1615
Q
R
E
G
D
R
E
S
W
S
S
G
E
D
_
Site 155
S1617
E
G
D
R
E
S
W
S
S
G
E
_
_
_
_
Site 156
S1618
G
D
R
E
S
W
S
S
G
E
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation