KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IDH2
Full Name:
Isocitrate dehydrogenase [NADP], mitochondrial
Alias:
ICD-M; IDH; IDHM; IDHP; IDP; Isocitrate dehydrogenase [NADP], mitochondrial; Isocitrate dehydrogenase 2 (NADP+) mitochondrial; NADP+-specific ICDH; Oxalosuccinate decarboxylase
Type:
EC 1.1.1.42; Carbohydrate Metabolism - citrate (TCA) cycle; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Mass (Da):
50909
Number AA:
452
UniProt ID:
P48735
International Prot ID:
IPI00011107
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0051287
GO:0004450
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006097
GO:0006102
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
Y
L
R
V
V
R
S
L
C
R
A
S
G
S
Site 2
S15
V
R
S
L
C
R
A
S
G
S
R
P
A
W
A
Site 3
S17
S
L
C
R
A
S
G
S
R
P
A
W
A
P
A
Site 4
T27
A
W
A
P
A
A
L
T
A
P
T
S
Q
E
Q
Site 5
S31
A
A
L
T
A
P
T
S
Q
E
Q
P
R
R
H
Site 6
Y39
Q
E
Q
P
R
R
H
Y
A
D
K
R
I
K
V
Site 7
Y81
H
V
D
I
Q
L
K
Y
F
D
L
G
L
P
N
Site 8
T92
G
L
P
N
R
D
Q
T
D
D
Q
V
T
I
D
Site 9
T97
D
Q
T
D
D
Q
V
T
I
D
S
A
L
A
T
Site 10
S100
D
D
Q
V
T
I
D
S
A
L
A
T
Q
K
Y
Site 11
Y107
S
A
L
A
T
Q
K
Y
S
V
A
V
K
C
A
Site 12
S108
A
L
A
T
Q
K
Y
S
V
A
V
K
C
A
T
Site 13
T115
S
V
A
V
K
C
A
T
I
T
P
D
E
A
R
Site 14
T117
A
V
K
C
A
T
I
T
P
D
E
A
R
V
E
Site 15
S134
K
L
K
K
M
W
K
S
P
N
G
T
I
R
N
Site 16
T138
M
W
K
S
P
N
G
T
I
R
N
I
L
G
G
Site 17
T169
P
G
W
T
K
P
I
T
I
G
R
H
A
H
G
Site 18
Y179
R
H
A
H
G
D
Q
Y
K
A
T
D
F
V
A
Site 19
T182
H
G
D
Q
Y
K
A
T
D
F
V
A
D
R
A
Site 20
T191
F
V
A
D
R
A
G
T
F
K
M
V
F
T
P
Site 21
T197
G
T
F
K
M
V
F
T
P
K
D
G
S
G
V
Site 22
Y210
G
V
K
E
W
E
V
Y
N
F
P
A
G
G
V
Site 23
Y222
G
G
V
G
M
G
M
Y
N
T
D
E
S
I
S
Site 24
T224
V
G
M
G
M
Y
N
T
D
E
S
I
S
G
F
Site 25
S227
G
M
Y
N
T
D
E
S
I
S
G
F
A
H
S
Site 26
Y247
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Site 27
Y258
K
N
T
I
L
K
A
Y
D
G
R
F
K
D
I
Site 28
Y274
Q
E
I
F
D
K
H
Y
K
T
D
F
D
K
N
Site 29
Y285
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Site 30
S317
N
Y
D
G
D
V
Q
S
D
I
L
A
Q
G
F
Site 31
T341
L
V
C
P
D
G
K
T
I
E
A
E
A
A
H
Site 32
Y355
H
G
T
V
T
R
H
Y
R
E
H
Q
K
G
R
Site 33
T364
E
H
Q
K
G
R
P
T
S
T
N
P
I
A
S
Site 34
S365
H
Q
K
G
R
P
T
S
T
N
P
I
A
S
I
Site 35
T366
Q
K
G
R
P
T
S
T
N
P
I
A
S
I
F
Site 36
S371
T
S
T
N
P
I
A
S
I
F
A
W
T
R
G
Site 37
S423
A
G
C
I
H
G
L
S
N
V
K
L
N
E
H
Site 38
S443
D
F
L
D
T
I
K
S
N
L
D
R
A
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation