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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3CG
Full Name:
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Alias:
5-bisphosphate 3-kinase catalytic subunit, gamma isoform; EC 2.7.1.153; P11G; Phosphatidylinositol-4; Phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3K; PI3K p110-gamma; PI3KG1; PI3Kgamma; PI3-kinase p110 subunit gamma; PK3CG; PtdIns-3-kinase p110
Type:
Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; Kinase, lipid
Mass (Da):
126454
Number AA:
1101
UniProt ID:
P48736
International Prot ID:
IPI00292690
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005942
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0046934
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
R
R
R
M
K
P
R
S
A
A
A
S
L
S
S
Site 2
S31
K
P
R
S
A
A
A
S
L
S
S
M
E
L
I
Site 3
S47
I
E
F
V
L
P
T
S
Q
R
K
C
K
S
P
Site 4
S53
T
S
Q
R
K
C
K
S
P
E
T
A
L
L
H
Site 5
Y88
T
S
V
A
A
D
F
Y
H
R
L
G
P
H
H
Site 6
Y100
P
H
H
F
L
L
L
Y
Q
K
K
G
Q
W
Y
Site 7
Y110
K
G
Q
W
Y
E
I
Y
D
K
Y
Q
V
V
Q
Site 8
Y113
W
Y
E
I
Y
D
K
Y
Q
V
V
Q
T
L
D
Site 9
S144
L
V
Q
R
H
P
P
S
E
E
S
Q
A
F
Q
Site 10
S147
R
H
P
P
S
E
E
S
Q
A
F
Q
R
Q
L
Site 11
S166
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
Site 12
T176
H
D
D
E
L
E
F
T
R
R
G
L
V
T
P
Site 13
T182
F
T
R
R
G
L
V
T
P
R
M
A
E
V
A
Site 14
S190
P
R
M
A
E
V
A
S
R
D
P
K
L
Y
A
Site 15
Y196
A
S
R
D
P
K
L
Y
A
M
H
P
W
V
T
Site 16
T203
Y
A
M
H
P
W
V
T
S
K
P
L
P
E
Y
Site 17
Y210
T
S
K
P
L
P
E
Y
L
W
K
K
I
A
N
Site 18
S227
I
F
I
V
I
H
R
S
T
T
S
Q
T
I
K
Site 19
T228
F
I
V
I
H
R
S
T
T
S
Q
T
I
K
V
Site 20
T229
I
V
I
H
R
S
T
T
S
Q
T
I
K
V
S
Site 21
S230
V
I
H
R
S
T
T
S
Q
T
I
K
V
S
P
Site 22
T232
H
R
S
T
T
S
Q
T
I
K
V
S
P
D
D
Site 23
S236
T
S
Q
T
I
K
V
S
P
D
D
T
P
G
A
Site 24
T240
I
K
V
S
P
D
D
T
P
G
A
I
L
Q
S
Site 25
T250
A
I
L
Q
S
F
F
T
K
M
A
K
K
K
S
Site 26
S257
T
K
M
A
K
K
K
S
L
M
D
I
P
E
S
Site 27
S264
S
L
M
D
I
P
E
S
Q
S
E
Q
D
F
V
Site 28
S266
M
D
I
P
E
S
Q
S
E
Q
D
F
V
L
R
Site 29
Y280
R
V
C
G
R
D
E
Y
L
V
G
E
T
P
I
Site 30
T285
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
Site 31
T309
E
I
H
V
V
L
D
T
P
P
D
P
A
L
D
Site 32
T330
W
P
L
V
D
D
C
T
G
V
T
G
Y
H
E
Site 33
T340
T
G
Y
H
E
Q
L
T
I
H
G
K
D
H
E
Site 34
T351
K
D
H
E
S
V
F
T
V
S
L
W
D
C
D
Site 35
T399
Q
V
L
C
Q
R
R
T
S
P
K
P
F
T
E
Site 36
S400
V
L
C
Q
R
R
T
S
P
K
P
F
T
E
E
Site 37
T405
R
T
S
P
K
P
F
T
E
E
V
L
W
N
V
Site 38
S442
C
G
K
A
P
A
L
S
S
K
A
S
A
E
S
Site 39
S443
G
K
A
P
A
L
S
S
K
A
S
A
E
S
P
Site 40
S446
P
A
L
S
S
K
A
S
A
E
S
P
S
S
E
Site 41
S449
S
S
K
A
S
A
E
S
P
S
S
E
S
K
G
Site 42
S452
A
S
A
E
S
P
S
S
E
S
K
G
K
V
Q
Site 43
Y480
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
Site 44
S496
G
K
G
E
D
Q
G
S
F
N
A
D
K
L
T
Site 45
T503
S
F
N
A
D
K
L
T
S
A
T
N
P
D
K
Site 46
S513
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
Site 47
S515
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
Site 48
S517
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
Site 49
T535
A
L
P
K
H
Q
P
T
P
D
P
E
G
D
R
Site 50
T568
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
Site 51
Y580
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
Site 52
Y589
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
Site 53
S595
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
Site 54
T607
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
R
R
Site 55
S620
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
Site 56
T627
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
Site 57
S636
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
Site 58
S650
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
Site 59
Y709
E
I
A
Q
S
R
H
Y
Q
Q
R
F
A
V
I
Site 60
S751
K
V
T
L
D
I
K
S
L
S
A
E
K
Y
D
Site 61
S753
T
L
D
I
K
S
L
S
A
E
K
Y
D
V
S
Site 62
Y757
K
S
L
S
A
E
K
Y
D
V
S
S
Q
V
I
Site 63
S760
S
A
E
K
Y
D
V
S
S
Q
V
I
S
Q
L
Site 64
S761
A
E
K
Y
D
V
S
S
Q
V
I
S
Q
L
K
Site 65
S765
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
Site 66
S777
K
L
E
N
L
Q
N
S
Q
L
P
E
S
F
R
Site 67
S782
Q
N
S
Q
L
P
E
S
F
R
V
P
Y
D
P
Site 68
Y787
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
Site 69
S806
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
Site 70
T821
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
Site 71
S853
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
Site 72
T887
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
Site 73
S915
N
H
W
L
K
E
K
S
P
T
E
E
K
F
Q
Site 74
T917
W
L
K
E
K
S
P
T
E
E
K
F
Q
A
A
Site 75
S974
H
I
L
G
N
Y
K
S
F
L
G
I
N
K
E
Site 76
T1002
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Site 77
S1003
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
Site 78
Y1017
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
Site 79
T1024
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
Site 80
Y1050
T
S
K
E
D
I
E
Y
I
R
D
A
L
T
V
Site 81
T1056
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
Site 82
Y1067
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
Site 83
S1101
I
K
Q
G
E
K
H
S
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation