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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MASP1
Full Name:
Mannan-binding lectin serine protease 1
Alias:
Complement-activating component of Ra-reactive factor; CRARF; CRARF1; EC 3.4.21.-; Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); Mannose-binding serine protease; MASP; MASP-1; Protease, serine, 5 (mannose-binding); PRSS5; Ra-reactive factor serine protease p100; RaRF
Type:
Secreted protein
Mass (Da):
79247
Number AA:
699
UniProt ID:
P48740
International Prot ID:
IPI00299307
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0048306
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0001867
GO:0045916
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
N
M
F
G
Q
I
Q
S
P
G
Y
P
D
S
Y
Site 2
Y36
G
Q
I
Q
S
P
G
Y
P
D
S
Y
P
S
D
Site 3
S39
Q
S
P
G
Y
P
D
S
Y
P
S
D
S
E
V
Site 4
Y40
S
P
G
Y
P
D
S
Y
P
S
D
S
E
V
T
Site 5
S42
G
Y
P
D
S
Y
P
S
D
S
E
V
T
W
N
Site 6
S44
P
D
S
Y
P
S
D
S
E
V
T
W
N
I
T
Site 7
T51
S
E
V
T
W
N
I
T
V
P
D
G
F
R
I
Site 8
Y61
D
G
F
R
I
K
L
Y
F
M
H
F
N
L
E
Site 9
Y71
H
F
N
L
E
S
S
Y
L
C
E
Y
D
Y
V
Site 10
Y75
E
S
S
Y
L
C
E
Y
D
Y
V
K
V
E
T
Site 11
Y77
S
Y
L
C
E
Y
D
Y
V
K
V
E
T
E
D
Site 12
T89
T
E
D
Q
V
L
A
T
F
C
G
R
E
T
T
Site 13
T95
A
T
F
C
G
R
E
T
T
D
T
E
Q
T
P
Site 14
T96
T
F
C
G
R
E
T
T
D
T
E
Q
T
P
G
Site 15
T98
C
G
R
E
T
T
D
T
E
Q
T
P
G
Q
E
Site 16
T101
E
T
T
D
T
E
Q
T
P
G
Q
E
V
V
L
Site 17
T117
P
G
S
F
M
S
I
T
F
R
S
D
F
S
N
Site 18
S120
F
M
S
I
T
F
R
S
D
F
S
N
E
E
R
Site 19
S123
I
T
F
R
S
D
F
S
N
E
E
R
F
T
G
Site 20
Y135
F
T
G
F
D
A
H
Y
M
A
V
D
V
D
E
Site 21
Y156
E
E
L
S
C
D
H
Y
C
H
N
Y
I
G
G
Site 22
T176
R
F
G
Y
I
L
H
T
D
N
R
T
C
R
V
Site 23
T180
I
L
H
T
D
N
R
T
C
R
V
E
C
S
D
Site 24
T191
E
C
S
D
N
L
F
T
Q
R
T
G
V
I
T
Site 25
T194
D
N
L
F
T
Q
R
T
G
V
I
T
S
P
D
Site 26
T198
T
Q
R
T
G
V
I
T
S
P
D
F
P
N
P
Site 27
S199
Q
R
T
G
V
I
T
S
P
D
F
P
N
P
Y
Site 28
Y206
S
P
D
F
P
N
P
Y
P
K
S
S
E
C
L
Site 29
S209
F
P
N
P
Y
P
K
S
S
E
C
L
Y
T
I
Site 30
S210
P
N
P
Y
P
K
S
S
E
C
L
Y
T
I
E
Site 31
Y214
P
K
S
S
E
C
L
Y
T
I
E
L
E
E
G
Site 32
T215
K
S
S
E
C
L
Y
T
I
E
L
E
E
G
F
Site 33
Y246
E
V
P
C
P
Y
D
Y
I
K
I
K
V
G
P
Site 34
S269
E
K
A
P
E
P
I
S
T
Q
S
H
S
V
L
Site 35
T270
K
A
P
E
P
I
S
T
Q
S
H
S
V
L
I
Site 36
S281
S
V
L
I
L
F
H
S
D
N
S
G
E
N
R
Site 37
S284
I
L
F
H
S
D
N
S
G
E
N
R
G
W
R
Site 38
S293
E
N
R
G
W
R
L
S
Y
R
A
A
G
N
E
Site 39
Y294
N
R
G
W
R
L
S
Y
R
A
A
G
N
E
C
Site 40
S315
V
H
G
K
I
E
P
S
Q
A
K
Y
F
F
K
Site 41
Y319
I
E
P
S
Q
A
K
Y
F
F
K
D
Q
V
L
Site 42
Y333
L
V
S
C
D
T
G
Y
K
V
L
K
D
N
V
Site 43
T354
I
E
C
L
K
D
G
T
W
S
N
K
I
P
T
Site 44
T379
E
L
E
H
G
L
I
T
F
S
T
R
N
N
L
Site 45
S381
E
H
G
L
I
T
F
S
T
R
N
N
L
T
T
Site 46
T382
H
G
L
I
T
F
S
T
R
N
N
L
T
T
Y
Site 47
T387
F
S
T
R
N
N
L
T
T
Y
K
S
E
I
K
Site 48
T388
S
T
R
N
N
L
T
T
Y
K
S
E
I
K
Y
Site 49
Y389
T
R
N
N
L
T
T
Y
K
S
E
I
K
Y
S
Site 50
Y395
T
Y
K
S
E
I
K
Y
S
C
Q
E
P
Y
Y
Site 51
Y401
K
Y
S
C
Q
E
P
Y
Y
K
M
L
N
N
N
Site 52
Y402
Y
S
C
Q
E
P
Y
Y
K
M
L
N
N
N
T
Site 53
Y412
L
N
N
N
T
G
I
Y
T
C
S
A
Q
G
V
Site 54
T460
R
P
A
Q
K
G
T
T
P
W
I
A
M
L
S
Site 55
S495
A
A
H
C
L
H
Q
S
L
D
P
E
D
P
T
Site 56
T502
S
L
D
P
E
D
P
T
L
R
D
S
D
L
L
Site 57
S506
E
D
P
T
L
R
D
S
D
L
L
S
P
S
D
Site 58
S510
L
R
D
S
D
L
L
S
P
S
D
F
K
I
I
Site 59
S526
G
K
H
W
R
L
R
S
D
E
N
E
Q
H
L
Site 60
Y544
H
T
T
L
H
P
Q
Y
D
P
N
T
F
E
N
Site 61
T548
H
P
Q
Y
D
P
N
T
F
E
N
D
V
A
L
Site 62
T652
D
S
G
G
P
M
V
T
L
N
R
E
R
G
Q
Site 63
Y661
N
R
E
R
G
Q
W
Y
L
V
G
T
V
S
W
Site 64
Y678
D
C
G
K
K
D
R
Y
G
V
Y
S
Y
I
H
Site 65
Y681
K
K
D
R
Y
G
V
Y
S
Y
I
H
H
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation