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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC9A3
Full Name:
Sodium/hydrogen exchanger 3
Alias:
Na/H exchanger 3; NAH3; NHE3; SL9A3; Solute carrier family 9 (sodium/hydrogen exchanger) member 3
Type:
Transport protein
Mass (Da):
92855
Number AA:
834
UniProt ID:
P48764
International Prot ID:
IPI00011184
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0031402
GO:0015385
PhosphoSite+
KinaseNET
Biological Process:
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Sodium/hydrogen exchanger 3 pan-specific antibody AB-NN326-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN326-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
P
G
G
A
H
G
E
S
G
G
F
Q
V
V
T
Site 2
T79
F
H
L
S
H
K
V
T
S
V
V
P
E
S
A
Site 3
T333
N
I
S
E
Q
S
A
T
T
V
R
Y
T
M
K
Site 4
T334
I
S
E
Q
S
A
T
T
V
R
Y
T
M
K
M
Site 5
T338
S
A
T
T
V
R
Y
T
M
K
M
L
A
S
S
Site 6
S468
Q
W
L
K
V
K
R
S
E
H
R
E
P
R
L
Site 7
S495
L
S
A
I
E
D
I
S
G
Q
I
G
H
N
Y
Site 8
Y502
S
G
Q
I
G
H
N
Y
L
R
D
K
W
S
H
Site 9
S516
H
F
D
R
K
F
L
S
R
V
L
M
R
R
S
Site 10
S523
S
R
V
L
M
R
R
S
A
Q
K
S
R
D
R
Site 11
S527
M
R
R
S
A
Q
K
S
R
D
R
I
L
N
V
Site 12
S545
L
N
L
K
D
A
I
S
Y
V
A
E
G
E
R
Site 13
Y546
N
L
K
D
A
I
S
Y
V
A
E
G
E
R
R
Site 14
S555
A
E
G
E
R
R
G
S
L
A
F
I
R
S
P
Site 15
S563
L
A
F
I
R
S
P
S
T
D
N
V
V
N
V
Site 16
T564
A
F
I
R
S
P
S
T
D
N
V
V
N
V
D
Site 17
T573
N
V
V
N
V
D
F
T
P
R
S
S
T
V
E
Site 18
S576
N
V
D
F
T
P
R
S
S
T
V
E
A
S
V
Site 19
S577
V
D
F
T
P
R
S
S
T
V
E
A
S
V
S
Site 20
T578
D
F
T
P
R
S
S
T
V
E
A
S
V
S
Y
Site 21
S582
R
S
S
T
V
E
A
S
V
S
Y
L
L
R
E
Site 22
S584
S
T
V
E
A
S
V
S
Y
L
L
R
E
N
V
Site 23
S600
A
V
C
L
D
M
Q
S
L
E
Q
R
R
R
S
Site 24
S607
S
L
E
Q
R
R
R
S
I
R
D
A
E
D
M
Site 25
T616
R
D
A
E
D
M
V
T
H
H
T
L
Q
Q
Y
Site 26
Y625
H
T
L
Q
Q
Y
L
Y
K
P
R
Q
E
Y
K
Site 27
Y631
L
Y
K
P
R
Q
E
Y
K
H
L
Y
S
R
H
Site 28
Y635
R
Q
E
Y
K
H
L
Y
S
R
H
E
L
T
P
Site 29
T641
L
Y
S
R
H
E
L
T
P
T
E
D
E
K
Q
Site 30
T643
S
R
H
E
L
T
P
T
E
D
E
K
Q
D
R
Site 31
T656
D
R
E
I
F
H
R
T
M
R
K
R
L
E
S
Site 32
S663
T
M
R
K
R
L
E
S
F
K
S
T
K
L
G
Site 33
S666
K
R
L
E
S
F
K
S
T
K
L
G
L
N
Q
Site 34
T667
R
L
E
S
F
K
S
T
K
L
G
L
N
Q
N
Site 35
Y681
N
K
K
A
A
K
L
Y
K
R
E
R
A
Q
K
Site 36
S692
R
A
Q
K
R
R
N
S
S
I
P
N
G
K
L
Site 37
S693
A
Q
K
R
R
N
S
S
I
P
N
G
K
L
P
Site 38
S703
N
G
K
L
P
M
E
S
P
A
Q
N
F
T
I
Site 39
S718
K
E
K
D
L
E
L
S
D
T
E
E
P
P
N
Site 40
T720
K
D
L
E
L
S
D
T
E
E
P
P
N
Y
D
Site 41
Y726
D
T
E
E
P
P
N
Y
D
E
E
M
S
G
G
Site 42
T744
L
A
S
V
T
K
D
T
A
S
D
S
P
A
G
Site 43
S746
S
V
T
K
D
T
A
S
D
S
P
A
G
I
D
Site 44
S748
T
K
D
T
A
S
D
S
P
A
G
I
D
N
P
Site 45
S758
G
I
D
N
P
V
F
S
P
D
E
A
L
D
R
Site 46
S766
P
D
E
A
L
D
R
S
L
L
A
R
L
P
P
Site 47
S776
A
R
L
P
P
W
L
S
P
G
E
T
V
V
P
Site 48
T780
P
W
L
S
P
G
E
T
V
V
P
S
Q
R
A
Site 49
S784
P
G
E
T
V
V
P
S
Q
R
A
R
T
Q
I
Site 50
T789
V
P
S
Q
R
A
R
T
Q
I
P
Y
S
P
G
Site 51
Y793
R
A
R
T
Q
I
P
Y
S
P
G
T
F
R
R
Site 52
S794
A
R
T
Q
I
P
Y
S
P
G
T
F
R
R
L
Site 53
T797
Q
I
P
Y
S
P
G
T
F
R
R
L
M
P
F
Site 54
S807
R
L
M
P
F
R
L
S
S
K
S
V
D
S
F
Site 55
S810
P
F
R
L
S
S
K
S
V
D
S
F
L
Q
A
Site 56
S813
L
S
S
K
S
V
D
S
F
L
Q
A
D
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation