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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TD02
Full Name:
Tryptophan 2,3-dioxygenase
Alias:
Tryptamin 2,3-dioxygenase;Tryptophan oxygenase;Tryptophan pyrrolase;Tryptophanase
Type:
Enzyme, oxidoreductase
Mass (Da):
47872
Number AA:
406
UniProt ID:
P48775
International Prot ID:
IPI00011206
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004833
PhosphoSite+
KinaseNET
Biological Process:
GO:0019674
GO:0055114
GO:0019441
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
L
G
N
N
F
G
Y
T
F
K
K
L
P
V
E
Site 2
S23
K
K
L
P
V
E
G
S
E
E
D
K
S
Q
T
Site 3
S28
E
G
S
E
E
D
K
S
Q
T
G
V
N
R
A
Site 4
S36
Q
T
G
V
N
R
A
S
K
G
G
L
I
Y
G
Site 5
S92
Q
I
L
W
E
L
D
S
V
R
E
I
F
Q
N
Site 6
Y146
D
F
N
D
F
R
E
Y
L
S
P
A
S
G
F
Site 7
S148
N
D
F
R
E
Y
L
S
P
A
S
G
F
Q
S
Site 8
S151
R
E
Y
L
S
P
A
S
G
F
Q
S
L
Q
F
Site 9
S155
S
P
A
S
G
F
Q
S
L
Q
F
R
L
L
E
Site 10
Y175
L
Q
N
M
R
V
P
Y
N
R
R
H
Y
R
D
Site 11
Y180
V
P
Y
N
R
R
H
Y
R
D
N
F
K
G
E
Site 12
S195
E
N
E
L
L
L
K
S
E
Q
E
K
T
L
L
Site 13
T200
L
K
S
E
Q
E
K
T
L
L
E
L
V
E
A
Site 14
T212
V
E
A
W
L
E
R
T
P
G
L
E
P
H
G
Site 15
T231
G
K
L
E
K
N
I
T
R
G
L
E
E
E
F
Site 16
S247
R
I
Q
A
K
E
E
S
E
E
K
E
E
Q
V
Site 17
S266
K
Q
K
E
V
L
L
S
L
F
D
E
K
R
H
Site 18
S278
K
R
H
E
H
L
L
S
K
G
E
R
R
L
S
Site 19
S285
S
K
G
E
R
R
L
S
Y
R
A
L
Q
G
A
Site 20
Y286
K
G
E
R
R
L
S
Y
R
A
L
Q
G
A
L
Site 21
Y296
L
Q
G
A
L
M
I
Y
F
Y
R
E
E
P
R
Site 22
S338
M
V
H
R
M
L
G
S
K
A
G
T
G
G
S
Site 23
T342
M
L
G
S
K
A
G
T
G
G
S
S
G
Y
H
Site 24
Y350
G
G
S
S
G
Y
H
Y
L
R
S
T
V
S
D
Site 25
T354
G
Y
H
Y
L
R
S
T
V
S
D
R
Y
K
V
Site 26
S356
H
Y
L
R
S
T
V
S
D
R
Y
K
V
F
V
Site 27
Y359
R
S
T
V
S
D
R
Y
K
V
F
V
D
L
F
Site 28
Y390
P
T
I
H
K
F
L
Y
T
A
E
Y
C
D
S
Site 29
Y394
K
F
L
Y
T
A
E
Y
C
D
S
S
Y
F
S
Site 30
S397
Y
T
A
E
Y
C
D
S
S
Y
F
S
S
D
E
Site 31
S398
T
A
E
Y
C
D
S
S
Y
F
S
S
D
E
S
Site 32
Y399
A
E
Y
C
D
S
S
Y
F
S
S
D
E
S
D
Site 33
S401
Y
C
D
S
S
Y
F
S
S
D
E
S
D
_
_
Site 34
S402
C
D
S
S
Y
F
S
S
D
E
S
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation