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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PXN
Full Name:
Paxillin
Alias:
Paired box protein Pax-1; PAX-1; PAXI; Paxillin; Paxillin alpha
Type:
Focal adhesion, Cytoplasm, Lamellipodium, Cell junction, Microtubule associated complex, Cytoskeleton protein
Mass (Da):
64533
Number AA:
591
UniProt ID:
P49023
International Prot ID:
IPI00220030
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005925
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0017166
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007160
GO:0034614
GO:0007172
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
L
L
A
D
L
E
S
T
T
S
H
I
S
K
Site 2
S16
A
D
L
E
S
T
T
S
H
I
S
K
R
P
V
Site 3
S19
E
S
T
T
S
H
I
S
K
R
P
V
F
L
S
Site 4
S26
S
K
R
P
V
F
L
S
E
E
T
P
Y
S
Y
Site 5
T29
P
V
F
L
S
E
E
T
P
Y
S
Y
P
T
G
Site 6
Y31
F
L
S
E
E
T
P
Y
S
Y
P
T
G
N
H
Site 7
S32
L
S
E
E
T
P
Y
S
Y
P
T
G
N
H
T
Site 8
Y33
S
E
E
T
P
Y
S
Y
P
T
G
N
H
T
Y
Site 9
T35
E
T
P
Y
S
Y
P
T
G
N
H
T
Y
Q
E
Site 10
Y40
Y
P
T
G
N
H
T
Y
Q
E
I
A
V
P
P
Site 11
S54
P
P
V
P
P
P
P
S
S
E
A
L
N
G
T
Site 12
S55
P
V
P
P
P
P
S
S
E
A
L
N
G
T
I
Site 13
S72
P
L
D
Q
W
Q
P
S
G
S
R
F
I
H
Q
Site 14
S83
F
I
H
Q
Q
P
Q
S
S
S
P
V
Y
G
S
Site 15
S84
I
H
Q
Q
P
Q
S
S
S
P
V
Y
G
S
S
Site 16
S85
H
Q
Q
P
Q
S
S
S
P
V
Y
G
S
S
A
Site 17
Y88
P
Q
S
S
S
P
V
Y
G
S
S
A
K
T
S
Site 18
S90
S
S
S
P
V
Y
G
S
S
A
K
T
S
S
V
Site 19
S91
S
S
P
V
Y
G
S
S
A
K
T
S
S
V
S
Site 20
T94
V
Y
G
S
S
A
K
T
S
S
V
S
N
P
Q
Site 21
S95
Y
G
S
S
A
K
T
S
S
V
S
N
P
Q
D
Site 22
S96
G
S
S
A
K
T
S
S
V
S
N
P
Q
D
S
Site 23
S98
S
A
K
T
S
S
V
S
N
P
Q
D
S
V
G
Site 24
S103
S
V
S
N
P
Q
D
S
V
G
S
P
C
S
R
Site 25
S106
N
P
Q
D
S
V
G
S
P
C
S
R
V
G
E
Site 26
S109
D
S
V
G
S
P
C
S
R
V
G
E
E
E
H
Site 27
Y118
V
G
E
E
E
H
V
Y
S
F
P
N
K
Q
K
Site 28
S119
G
E
E
E
H
V
Y
S
F
P
N
K
Q
K
S
Site 29
S126
S
F
P
N
K
Q
K
S
A
E
P
S
P
T
V
Site 30
S130
K
Q
K
S
A
E
P
S
P
T
V
M
S
T
S
Site 31
T132
K
S
A
E
P
S
P
T
V
M
S
T
S
L
G
Site 32
S135
E
P
S
P
T
V
M
S
T
S
L
G
S
N
L
Site 33
T136
P
S
P
T
V
M
S
T
S
L
G
S
N
L
S
Site 34
S137
S
P
T
V
M
S
T
S
L
G
S
N
L
S
E
Site 35
S140
V
M
S
T
S
L
G
S
N
L
S
E
L
D
R
Site 36
S143
T
S
L
G
S
N
L
S
E
L
D
R
L
L
L
Site 37
S169
F
P
A
D
E
A
N
S
S
P
P
L
P
G
A
Site 38
S170
P
A
D
E
A
N
S
S
P
P
L
P
G
A
L
Site 39
S178
P
P
L
P
G
A
L
S
P
L
Y
G
V
P
E
Site 40
Y181
P
G
A
L
S
P
L
Y
G
V
P
E
T
N
S
Site 41
T186
P
L
Y
G
V
P
E
T
N
S
P
L
G
G
K
Site 42
S188
Y
G
V
P
E
T
N
S
P
L
G
G
K
A
G
Site 43
T198
G
G
K
A
G
P
L
T
K
E
K
P
K
R
N
Site 44
S216
G
L
E
D
V
R
P
S
V
E
S
L
L
D
E
Site 45
S219
D
V
R
P
S
V
E
S
L
L
D
E
L
E
S
Site 46
S226
S
L
L
D
E
L
E
S
S
V
P
S
P
V
P
Site 47
S227
L
L
D
E
L
E
S
S
V
P
S
P
V
P
A
Site 48
S230
E
L
E
S
S
V
P
S
P
V
P
A
I
T
V
Site 49
T236
P
S
P
V
P
A
I
T
V
N
Q
G
E
M
S
Site 50
S243
T
V
N
Q
G
E
M
S
S
P
Q
R
V
T
S
Site 51
S244
V
N
Q
G
E
M
S
S
P
Q
R
V
T
S
T
Site 52
T249
M
S
S
P
Q
R
V
T
S
T
Q
Q
Q
T
R
Site 53
S250
S
S
P
Q
R
V
T
S
T
Q
Q
Q
T
R
I
Site 54
T251
S
P
Q
R
V
T
S
T
Q
Q
Q
T
R
I
S
Site 55
T255
V
T
S
T
Q
Q
Q
T
R
I
S
A
S
S
A
Site 56
S258
T
Q
Q
Q
T
R
I
S
A
S
S
A
T
R
E
Site 57
S260
Q
Q
T
R
I
S
A
S
S
A
T
R
E
L
D
Site 58
S261
Q
T
R
I
S
A
S
S
A
T
R
E
L
D
E
Site 59
T263
R
I
S
A
S
S
A
T
R
E
L
D
E
L
M
Site 60
S272
E
L
D
E
L
M
A
S
L
S
D
F
K
I
Q
Site 61
S274
D
E
L
M
A
S
L
S
D
F
K
I
Q
D
L
Site 62
S302
K
P
G
S
Q
L
D
S
M
L
G
S
L
Q
S
Site 63
S303
P
R
D
G
G
R
S
S
P
G
G
Q
D
E
G
Site 64
T318
G
F
M
A
Q
G
K
T
G
S
S
S
P
P
G
Site 65
S320
M
A
Q
G
K
T
G
S
S
S
P
P
G
G
P
Site 66
S321
A
Q
G
K
T
G
S
S
S
P
P
G
G
P
P
Site 67
S322
Q
G
K
T
G
S
S
S
P
P
G
G
P
P
K
Site 68
S332
G
G
P
P
K
P
G
S
Q
L
D
S
M
L
G
Site 69
S336
K
P
G
S
Q
L
D
S
M
L
G
S
L
Q
S
Site 70
S340
Q
L
D
S
M
L
G
S
L
Q
S
D
L
N
K
Site 71
T376
V
V
T
A
M
G
K
T
W
H
P
E
H
F
V
Site 72
S393
H
C
Q
E
E
I
G
S
R
N
F
F
E
R
D
Site 73
Y404
F
E
R
D
G
Q
P
Y
C
E
K
D
Y
H
N
Site 74
Y409
Q
P
Y
C
E
K
D
Y
H
N
L
F
S
P
R
Site 75
S414
K
D
Y
H
N
L
F
S
P
R
C
Y
Y
C
N
Site 76
Y419
L
F
S
P
R
C
Y
Y
C
N
G
P
I
L
D
Site 77
T430
P
I
L
D
K
V
V
T
A
L
D
R
T
W
H
Site 78
T435
V
V
T
A
L
D
R
T
W
H
P
E
H
F
F
Site 79
Y463
H
E
K
D
G
K
A
Y
C
R
K
D
Y
F
D
Site 80
Y468
K
A
Y
C
R
K
D
Y
F
D
M
F
A
P
K
Site 81
S489
A
I
L
E
N
Y
I
S
A
L
N
T
L
W
H
Site 82
S513
F
T
P
F
V
N
G
S
F
F
E
H
D
G
Q
Site 83
Y522
F
E
H
D
G
Q
P
Y
C
E
V
H
Y
H
E
Site 84
Y527
Q
P
Y
C
E
V
H
Y
H
E
R
R
G
S
L
Site 85
S533
H
Y
H
E
R
R
G
S
L
C
S
G
C
Q
K
Site 86
S536
E
R
R
G
S
L
C
S
G
C
Q
K
P
I
T
Site 87
T543
S
G
C
Q
K
P
I
T
G
R
C
I
T
A
M
Site 88
T572
L
K
Q
L
N
K
G
T
F
K
E
Q
N
D
K
Site 89
Y581
K
E
Q
N
D
K
P
Y
C
Q
N
C
F
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation