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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NR2C2
Full Name:
Nuclear receptor subfamily 2 group C member 2
Alias:
nuclear receptor subfamily 2, group C, member 2; TAK1; TR2R1; TR4
Type:
Transcription protein (receptor), nuclear
Mass (Da):
65414
Number AA:
596
UniProt ID:
P49116
International Prot ID:
IPI00749258
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003707
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
I
Q
I
I
S
T
D
S
A
V
A
S
P
Q
R
Site 2
S19
S
T
D
S
A
V
A
S
P
Q
R
I
Q
I
V
Site 3
T27
P
Q
R
I
Q
I
V
T
D
Q
Q
T
G
Q
K
Site 4
S44
I
V
T
A
V
D
A
S
G
S
P
K
Q
Q
F
Site 5
S46
T
A
V
D
A
S
G
S
P
K
Q
Q
F
I
L
Site 6
S55
K
Q
Q
F
I
L
T
S
P
D
G
A
G
T
G
Site 7
S68
T
G
K
V
I
L
A
S
P
E
T
S
S
A
K
Site 8
S82
K
Q
L
I
F
T
T
S
D
N
L
V
P
G
R
Site 9
T94
P
G
R
I
Q
I
V
T
D
S
A
S
V
E
R
Site 10
S98
Q
I
V
T
D
S
A
S
V
E
R
L
L
G
K
Site 11
T106
V
E
R
L
L
G
K
T
D
V
Q
R
P
Q
V
Site 12
Y116
Q
R
P
Q
V
V
E
Y
C
V
V
C
G
D
K
Site 13
S125
V
V
C
G
D
K
A
S
G
R
H
Y
G
A
V
Site 14
Y129
D
K
A
S
G
R
H
Y
G
A
V
S
C
E
G
Site 15
T150
R
S
V
R
K
N
L
T
Y
S
C
R
S
N
Q
Site 16
Y151
S
V
R
K
N
L
T
Y
S
C
R
S
N
Q
D
Site 17
S186
E
M
G
M
K
M
E
S
V
Q
S
E
R
K
P
Site 18
S189
M
K
M
E
S
V
Q
S
E
R
K
P
F
D
V
Site 19
Y212
A
A
S
T
E
K
I
Y
I
R
K
D
L
R
S
Site 20
S219
Y
I
R
K
D
L
R
S
P
L
I
A
T
P
T
Site 21
T224
L
R
S
P
L
I
A
T
P
T
F
V
A
D
K
Site 22
T226
S
P
L
I
A
T
P
T
F
V
A
D
K
D
G
Site 23
T237
D
K
D
G
A
R
Q
T
G
L
L
D
P
G
M
Site 24
S265
T
V
L
L
A
T
D
S
K
A
E
T
S
Q
G
Site 25
T269
A
T
D
S
K
A
E
T
S
Q
G
A
L
G
T
Site 26
S270
T
D
S
K
A
E
T
S
Q
G
A
L
G
T
L
Site 27
S288
V
T
S
L
A
N
L
S
E
S
L
N
N
G
D
Site 28
S290
S
L
A
N
L
S
E
S
L
N
N
G
D
T
S
Site 29
T296
E
S
L
N
N
G
D
T
S
E
I
Q
P
E
D
Site 30
S305
E
I
Q
P
E
D
Q
S
A
S
E
I
T
R
A
Site 31
T315
E
I
T
R
A
F
D
T
L
A
K
A
L
N
T
Site 32
T322
T
L
A
K
A
L
N
T
T
D
S
S
S
S
P
Site 33
T323
L
A
K
A
L
N
T
T
D
S
S
S
S
P
S
Site 34
S325
K
A
L
N
T
T
D
S
S
S
S
P
S
L
A
Site 35
S326
A
L
N
T
T
D
S
S
S
S
P
S
L
A
D
Site 36
S327
L
N
T
T
D
S
S
S
S
P
S
L
A
D
G
Site 37
S328
N
T
T
D
S
S
S
S
P
S
L
A
D
G
I
Site 38
S330
T
D
S
S
S
S
P
S
L
A
D
G
I
D
T
Site 39
T337
S
L
A
D
G
I
D
T
S
G
G
G
S
I
H
Site 40
S342
I
D
T
S
G
G
G
S
I
H
V
I
S
R
D
Site 41
S347
G
G
S
I
H
V
I
S
R
D
Q
S
T
P
I
Site 42
S351
H
V
I
S
R
D
Q
S
T
P
I
I
E
V
E
Site 43
T352
V
I
S
R
D
Q
S
T
P
I
I
E
V
E
G
Site 44
S363
E
V
E
G
P
L
L
S
D
T
H
V
T
F
K
Site 45
T365
E
G
P
L
L
S
D
T
H
V
T
F
K
L
T
Site 46
S375
T
F
K
L
T
M
P
S
P
M
P
E
Y
L
N
Site 47
Y380
M
P
S
P
M
P
E
Y
L
N
V
H
Y
I
C
Site 48
Y385
P
E
Y
L
N
V
H
Y
I
C
E
S
A
S
R
Site 49
S461
S
I
Q
E
D
K
L
S
G
D
R
I
K
Q
V
Site 50
S481
K
L
Q
E
F
C
N
S
M
A
K
L
D
I
D
Site 51
Y490
A
K
L
D
I
D
G
Y
E
Y
A
Y
L
K
A
Site 52
S510
P
D
H
P
G
L
T
S
T
S
Q
I
E
K
F
Site 53
S512
H
P
G
L
T
S
T
S
Q
I
E
K
F
Q
E
Site 54
Y528
A
Q
M
E
L
Q
D
Y
V
Q
K
T
Y
S
E
Site 55
T532
L
Q
D
Y
V
Q
K
T
Y
S
E
D
T
Y
R
Site 56
Y538
K
T
Y
S
E
D
T
Y
R
L
A
R
I
L
V
Site 57
T558
R
L
M
S
S
N
I
T
E
E
L
F
F
T
G
Site 58
Y587
L
K
M
E
T
A
E
Y
N
G
Q
I
T
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation