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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TGM4
Full Name:
Protein-glutamine gamma-glutamyltransferase 4
Alias:
Fibrinoligase; Prostate transglutaminase; Prostate-specific transglutaminase; Protein-glutamine gamma-glutamyltransferase 4; TG(P); TGP; Transglutaminase 4 (prostate)
Type:
Transferase; EC 2.3.2.13
Mass (Da):
77145
Number AA:
684
UniProt ID:
P49221
International Prot ID:
IPI00290396
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0005509
GO:0003810
PhosphoSite+
KinaseNET
Biological Process:
GO:0018149
GO:0018184
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
H
T
W
E
F
Q
T
S
S
P
V
F
R
R
G
Site 2
S33
T
W
E
F
Q
T
S
S
P
V
F
R
R
G
Q
Site 3
S63
H
Q
L
K
L
E
F
S
T
G
P
N
P
S
I
Site 4
S69
F
S
T
G
P
N
P
S
I
A
K
H
T
L
V
Site 5
T82
L
V
V
L
D
P
R
T
P
S
D
H
Y
N
W
Site 6
S84
V
L
D
P
R
T
P
S
D
H
Y
N
W
Q
A
Site 7
Y87
P
R
T
P
S
D
H
Y
N
W
Q
A
T
L
Q
Site 8
T102
N
E
S
G
K
E
V
T
V
A
V
T
S
S
P
Site 9
Y116
P
N
A
I
L
G
K
Y
Q
L
N
V
K
T
G
Site 10
S129
T
G
N
H
I
L
K
S
E
E
N
I
L
Y
L
Site 11
Y135
K
S
E
E
N
I
L
Y
L
L
F
N
P
W
C
Site 12
Y158
D
E
D
E
R
K
E
Y
I
L
N
D
T
G
C
Site 13
Y167
L
N
D
T
G
C
H
Y
V
G
A
A
R
S
I
Site 14
S200
I
S
L
L
T
E
S
S
L
K
P
T
D
R
R
Site 15
T204
T
E
S
S
L
K
P
T
D
R
R
D
P
V
L
Site 16
Y237
I
G
N
W
T
G
D
Y
E
G
G
T
A
P
Y
Site 17
S249
A
P
Y
K
W
T
G
S
A
P
I
L
Q
Q
Y
Site 18
Y256
S
A
P
I
L
Q
Q
Y
Y
N
T
K
Q
A
V
Site 19
T290
G
I
P
A
R
S
V
T
G
F
D
S
A
H
D
Site 20
S294
R
S
V
T
G
F
D
S
A
H
D
T
E
R
N
Site 21
T298
G
F
D
S
A
H
D
T
E
R
N
L
T
V
D
Site 22
T303
H
D
T
E
R
N
L
T
V
D
T
Y
V
N
E
Site 23
T306
E
R
N
L
T
V
D
T
Y
V
N
E
N
G
E
Site 24
Y307
R
N
L
T
V
D
T
Y
V
N
E
N
G
E
K
Site 25
T352
G
W
Q
A
V
D
A
T
P
Q
E
R
S
Q
G
Site 26
S357
D
A
T
P
Q
E
R
S
Q
G
V
F
C
C
G
Site 27
S366
G
V
F
C
C
G
P
S
P
L
T
A
I
R
K
Site 28
T369
C
C
G
P
S
P
L
T
A
I
R
K
G
D
I
Site 29
S387
Y
D
T
R
F
V
F
S
E
V
N
G
D
R
L
Site 30
S411
Q
E
E
L
H
V
I
S
M
E
T
T
S
I
G
Site 31
T415
H
V
I
S
M
E
T
T
S
I
G
K
N
I
S
Site 32
S422
T
S
I
G
K
N
I
S
T
K
A
V
G
Q
D
Site 33
T435
Q
D
R
R
R
D
I
T
Y
E
Y
K
Y
P
E
Site 34
Y436
D
R
R
R
D
I
T
Y
E
Y
K
Y
P
E
G
Site 35
Y438
R
R
D
I
T
Y
E
Y
K
Y
P
E
G
S
S
Site 36
Y440
D
I
T
Y
E
Y
K
Y
P
E
G
S
S
E
E
Site 37
S445
Y
K
Y
P
E
G
S
S
E
E
R
Q
V
M
D
Site 38
S459
D
H
A
F
L
L
L
S
S
E
R
E
H
R
R
Site 39
S460
H
A
F
L
L
L
S
S
E
R
E
H
R
R
P
Site 40
S476
K
E
N
F
L
H
M
S
V
Q
S
D
D
V
L
Site 41
T498
T
V
I
L
K
R
K
T
A
A
L
Q
N
V
N
Site 42
Y515
G
S
F
E
L
Q
L
Y
T
G
K
K
M
A
K
Site 43
S530
L
C
D
L
N
K
T
S
Q
I
Q
G
Q
V
S
Site 44
S537
S
Q
I
Q
G
Q
V
S
E
V
T
L
T
L
D
Site 45
T542
Q
V
S
E
V
T
L
T
L
D
S
K
T
Y
I
Site 46
S545
E
V
T
L
T
L
D
S
K
T
Y
I
N
S
L
Site 47
S551
D
S
K
T
Y
I
N
S
L
A
I
L
D
D
E
Site 48
S578
E
S
K
E
I
M
A
S
E
V
F
T
S
F
Q
Site 49
S583
M
A
S
E
V
F
T
S
F
Q
Y
P
E
F
S
Site 50
Y586
E
V
F
T
S
F
Q
Y
P
E
F
S
I
E
L
Site 51
S630
S
L
E
S
L
G
I
S
S
L
Q
T
S
D
H
Site 52
S631
L
E
S
L
G
I
S
S
L
Q
T
S
D
H
G
Site 53
T634
L
G
I
S
S
L
Q
T
S
D
H
G
T
V
Q
Site 54
S635
G
I
S
S
L
Q
T
S
D
H
G
T
V
Q
P
Site 55
T639
L
Q
T
S
D
H
G
T
V
Q
P
G
E
T
I
Site 56
S648
Q
P
G
E
T
I
Q
S
Q
I
K
C
T
P
I
Site 57
T653
I
Q
S
Q
I
K
C
T
P
I
K
T
G
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation