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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC11A2
Full Name:
Natural resistance-associated macrophage protein 2
Alias:
DCT1; divalent metal transporter 1; DMT1; natural resistance-associated macrophage 2; NRAM2; NRAMP 2; NRAMP2; solute carrier 11 (proton-coupled divalent metal ion transporters), 2; solute carrier family 11 (proton-coupled divalent metal ion transporters) member 2
Type:
Membrane protein, integral; Transporter
Mass (Da):
62266
Number AA:
568
UniProt ID:
P49281
International Prot ID:
IPI00394753
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0045178
GO:0009986
Uniprot
OncoNet
Molecular Function:
GO:0015086
GO:0015087
GO:0005375
PhosphoSite+
KinaseNET
Biological Process:
GO:0006919
GO:0070574
GO:0034599
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
G
P
E
Q
K
M
S
D
D
S
V
S
G
D
Site 2
S13
E
Q
K
M
S
D
D
S
V
S
G
D
H
G
E
Site 3
S15
K
M
S
D
D
S
V
S
G
D
H
G
E
S
A
Site 4
S21
V
S
G
D
H
G
E
S
A
S
L
G
N
I
N
Site 5
S23
G
D
H
G
E
S
A
S
L
G
N
I
N
P
A
Site 6
Y31
L
G
N
I
N
P
A
Y
S
N
P
S
L
S
Q
Site 7
S32
G
N
I
N
P
A
Y
S
N
P
S
L
S
Q
S
Site 8
S35
N
P
A
Y
S
N
P
S
L
S
Q
S
P
G
D
Site 9
S37
A
Y
S
N
P
S
L
S
Q
S
P
G
D
S
E
Site 10
S39
S
N
P
S
L
S
Q
S
P
G
D
S
E
E
Y
Site 11
S43
L
S
Q
S
P
G
D
S
E
E
Y
F
A
T
Y
Site 12
Y46
S
P
G
D
S
E
E
Y
F
A
T
Y
F
N
E
Site 13
T49
D
S
E
E
Y
F
A
T
Y
F
N
E
K
I
S
Site 14
Y50
S
E
E
Y
F
A
T
Y
F
N
E
K
I
S
I
Site 15
S56
T
Y
F
N
E
K
I
S
I
P
E
E
E
Y
S
Site 16
Y62
I
S
I
P
E
E
E
Y
S
C
F
S
F
R
K
Site 17
S63
S
I
P
E
E
E
Y
S
C
F
S
F
R
K
L
Site 18
S92
L
D
P
G
N
I
E
S
D
L
Q
S
G
A
V
Site 19
S96
N
I
E
S
D
L
Q
S
G
A
V
A
G
F
K
Site 20
T129
A
A
R
L
G
V
V
T
G
L
H
L
A
E
V
Site 21
Y141
A
E
V
C
H
R
Q
Y
P
K
V
P
R
V
I
Site 22
Y226
A
L
T
F
G
Y
E
Y
V
T
V
K
P
S
Q
Site 23
T228
T
F
G
Y
E
Y
V
T
V
K
P
S
Q
S
Q
Site 24
S232
E
Y
V
T
V
K
P
S
Q
S
Q
V
L
K
G
Site 25
S234
V
T
V
K
P
S
Q
S
Q
V
L
K
G
M
F
Site 26
T250
P
S
C
S
G
C
R
T
P
Q
I
E
Q
A
V
Site 27
S273
P
H
N
M
Y
L
H
S
A
L
V
K
S
R
Q
Site 28
S278
L
H
S
A
L
V
K
S
R
Q
V
N
R
N
N
Site 29
Y295
E
V
R
E
A
N
K
Y
F
F
I
E
S
C
I
Site 30
T335
E
Q
V
V
E
V
C
T
N
T
S
S
P
H
A
Site 31
S339
E
V
C
T
N
T
S
S
P
H
A
G
L
F
P
Site 32
T351
L
F
P
K
D
N
S
T
L
A
V
D
I
Y
K
Site 33
T389
A
G
Q
S
S
T
M
T
G
T
Y
S
G
Q
F
Site 34
S468
T
S
L
R
P
V
M
S
D
F
A
N
G
L
G
Site 35
S564
L
N
T
M
D
A
D
S
L
V
S
R
_
_
_
Site 36
S567
M
D
A
D
S
L
V
S
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation