KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FASN
Full Name:
Fatty acid synthase
Alias:
[Acyl-carrier-protein] S-acetyltransferase; FAS; fatty acid synthase; SDR27X1; short chain dehydrogenase/reductase family 27X, member 1
Type:
Oxidoreductase; Hydrolase; Acetyltransferase; EC 2.3.1.41; EC 2.3.1.85; Lipid Metabolism - fatty acid biosynthesis; EC 1.3.1.10; EC 2.3.1.39; Lyase; EC 4.2.1.61; EC 1.1.1.100; EC 3.1.2.14; EC 2.3.1.38
Mass (Da):
273427
Number AA:
2511
UniProt ID:
P49327
International Prot ID:
IPI00026781
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0004317
GO:0004316
GO:0004315
PhosphoSite+
KinaseNET
Biological Process:
GO:0006633
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
M
S
G
K
L
P
E
S
E
N
L
Q
E
F
W
Site 2
T34
I
G
G
V
D
M
V
T
D
D
D
R
R
W
K
Site 3
Y45
R
R
W
K
A
G
L
Y
G
L
P
R
R
S
G
Site 4
S51
L
Y
G
L
P
R
R
S
G
K
L
K
D
L
S
Site 5
S58
S
G
K
L
K
D
L
S
R
F
D
A
S
F
F
Site 6
S63
D
L
S
R
F
D
A
S
F
F
G
V
H
P
K
Site 7
S99
D
G
G
I
N
P
D
S
L
R
G
T
H
T
G
Site 8
T103
N
P
D
S
L
R
G
T
H
T
G
V
W
V
G
Site 9
T116
V
G
V
S
G
S
E
T
S
E
A
L
S
R
D
Site 10
S117
G
V
S
G
S
E
T
S
E
A
L
S
R
D
P
Site 11
S121
S
E
T
S
E
A
L
S
R
D
P
E
T
L
V
Site 12
Y130
D
P
E
T
L
V
G
Y
S
M
V
G
C
Q
R
Site 13
Y172
L
M
A
L
Q
N
A
Y
Q
A
I
H
S
G
Q
Site 14
S207
F
L
R
L
G
M
L
S
P
E
G
T
C
K
A
Site 15
T211
G
M
L
S
P
E
G
T
C
K
A
F
D
T
A
Site 16
T217
G
T
C
K
A
F
D
T
A
G
N
G
Y
C
R
Site 17
Y222
F
D
T
A
G
N
G
Y
C
R
S
E
G
V
V
Site 18
T262
G
F
K
E
Q
G
V
T
F
P
S
G
D
I
Q
Site 19
S275
I
Q
E
Q
L
I
R
S
L
Y
Q
S
A
G
V
Site 20
Y277
E
Q
L
I
R
S
L
Y
Q
S
A
G
V
A
P
Site 21
S279
L
I
R
S
L
Y
Q
S
A
G
V
A
P
E
S
Site 22
S286
S
A
G
V
A
P
E
S
F
E
Y
I
E
A
H
Site 23
Y289
V
A
P
E
S
F
E
Y
I
E
A
H
G
T
G
Site 24
T295
E
Y
I
E
A
H
G
T
G
T
K
V
G
D
P
Site 25
T325
E
P
L
L
I
G
S
T
K
S
N
M
G
H
P
Site 26
S327
L
L
I
G
S
T
K
S
N
M
G
H
P
E
P
Site 27
S336
M
G
H
P
E
P
A
S
G
L
A
A
L
A
K
Site 28
S361
A
P
N
L
H
F
H
S
P
N
P
E
I
P
A
Site 29
S392
G
G
N
V
G
I
N
S
F
G
F
G
G
S
N
Site 30
T408
H
I
I
L
R
P
N
T
Q
P
P
P
A
P
A
Site 31
T419
P
A
P
A
P
H
A
T
L
P
R
L
L
R
A
Site 32
S427
L
P
R
L
L
R
A
S
G
R
T
P
E
A
V
Site 33
T430
L
L
R
A
S
G
R
T
P
E
A
V
Q
K
L
Site 34
S445
L
E
Q
G
L
R
H
S
Q
D
L
A
F
L
S
Site 35
Y470
T
A
M
P
F
R
G
Y
A
V
L
G
G
E
R
Site 36
S509
Q
W
R
G
M
G
L
S
L
M
R
L
D
R
F
Site 37
S519
R
L
D
R
F
R
D
S
I
L
R
S
D
E
A
Site 38
S523
F
R
D
S
I
L
R
S
D
E
A
V
K
P
F
Site 39
S535
K
P
F
G
L
K
V
S
Q
L
L
L
S
T
D
Site 40
S540
K
V
S
Q
L
L
L
S
T
D
E
S
T
F
D
Site 41
T545
L
L
S
T
D
E
S
T
F
D
D
I
V
H
S
Site 42
Y604
E
E
A
V
L
A
A
Y
W
R
G
Q
C
I
K
Site 43
S626
A
M
A
A
V
G
L
S
W
E
E
C
K
Q
R
Site 44
T648
A
C
H
N
S
K
D
T
V
T
I
S
G
P
Q
Site 45
S652
S
K
D
T
V
T
I
S
G
P
Q
A
P
V
F
Site 46
S709
I
R
E
P
K
P
R
S
A
R
W
L
S
T
S
Site 47
S714
P
R
S
A
R
W
L
S
T
S
I
P
E
A
Q
Site 48
T715
R
S
A
R
W
L
S
T
S
I
P
E
A
Q
W
Site 49
S716
S
A
R
W
L
S
T
S
I
P
E
A
Q
W
H
Site 50
S724
I
P
E
A
Q
W
H
S
S
L
A
R
T
S
S
Site 51
S725
P
E
A
Q
W
H
S
S
L
A
R
T
S
S
A
Site 52
T729
W
H
S
S
L
A
R
T
S
S
A
E
Y
N
V
Site 53
S730
H
S
S
L
A
R
T
S
S
A
E
Y
N
V
N
Site 54
S731
S
S
L
A
R
T
S
S
A
E
Y
N
V
N
N
Site 55
S778
L
K
R
G
L
K
P
S
C
T
I
I
P
L
M
Site 56
T780
R
G
L
K
P
S
C
T
I
I
P
L
M
K
K
Site 57
S806
G
I
G
R
L
H
L
S
G
I
D
A
N
P
N
Site 58
S831
P
R
G
T
P
L
I
S
P
L
I
K
W
D
H
Site 59
S854
A
E
D
F
P
N
G
S
G
S
P
S
A
A
I
Site 60
S856
D
F
P
N
G
S
G
S
P
S
A
A
I
Y
N
Site 61
S858
P
N
G
S
G
S
P
S
A
A
I
Y
N
I
D
Site 62
Y862
G
S
P
S
A
A
I
Y
N
I
D
T
S
S
E
Site 63
T866
A
A
I
Y
N
I
D
T
S
S
E
S
P
D
H
Site 64
S867
A
I
Y
N
I
D
T
S
S
E
S
P
D
H
Y
Site 65
S868
I
Y
N
I
D
T
S
S
E
S
P
D
H
Y
L
Site 66
S870
N
I
D
T
S
S
E
S
P
D
H
Y
L
V
D
Site 67
Y874
S
S
E
S
P
D
H
Y
L
V
D
H
T
L
D
Site 68
T879
D
H
Y
L
V
D
H
T
L
D
G
R
V
L
F
Site 69
T898
Y
L
S
I
V
W
K
T
L
A
R
A
L
G
L
Site 70
T928
Q
A
T
I
L
P
K
T
G
T
V
S
L
E
V
Site 71
T930
T
I
L
P
K
T
G
T
V
S
L
E
V
R
L
Site 72
S941
E
V
R
L
L
E
A
S
R
A
F
E
V
S
E
Site 73
Y959
L
V
V
S
G
K
V
Y
Q
W
D
D
P
D
P
Site 74
S974
R
L
F
D
H
P
E
S
P
T
P
N
P
T
E
Site 75
T976
F
D
H
P
E
S
P
T
P
N
P
T
E
P
L
Site 76
T980
E
S
P
T
P
N
P
T
E
P
L
F
L
A
Q
Site 77
Y999
K
E
L
R
L
R
G
Y
D
Y
G
P
H
F
Q
Site 78
Y1001
L
R
L
R
G
Y
D
Y
G
P
H
F
Q
G
I
Site 79
S1012
F
Q
G
I
L
E
A
S
L
E
G
D
S
G
R
Site 80
S1017
E
A
S
L
E
G
D
S
G
R
L
L
W
K
D
Site 81
Y1047
G
S
A
K
H
G
L
Y
L
P
T
R
V
T
A
Site 82
T1061
A
I
H
I
D
P
A
T
H
R
Q
K
L
Y
T
Site 83
T1068
T
H
R
Q
K
L
Y
T
L
Q
D
K
A
Q
V
Site 84
T1099
V
H
I
S
G
L
H
T
E
S
A
P
R
R
Q
Site 85
T1120
I
L
E
K
F
C
F
T
P
H
T
E
E
G
C
Site 86
T1123
K
F
C
F
T
P
H
T
E
E
G
C
L
S
E
Site 87
S1129
H
T
E
E
G
C
L
S
E
R
A
A
L
Q
E
Site 88
S1174
A
Q
I
P
R
D
P
S
Q
Q
E
L
P
R
L
Site 89
S1237
T
A
V
E
N
M
P
S
L
K
M
K
V
V
E
Site 90
Y1253
L
A
G
H
G
H
L
Y
S
R
I
P
G
L
L
Site 91
S1254
A
G
H
G
H
L
Y
S
R
I
P
G
L
L
S
Site 92
S1269
P
H
P
L
L
Q
L
S
Y
T
A
T
D
R
H
Site 93
T1271
P
L
L
Q
L
S
Y
T
A
T
D
R
H
P
Q
Site 94
T1273
L
Q
L
S
Y
T
A
T
D
R
H
P
Q
A
L
Site 95
S1305
D
P
A
D
P
A
P
S
A
L
G
S
A
D
L
Site 96
Y1367
L
T
S
T
E
P
Q
Y
G
Q
G
I
L
S
Q
Site 97
S1373
Q
Y
G
Q
G
I
L
S
Q
D
A
W
E
S
L
Site 98
S1379
L
S
Q
D
A
W
E
S
L
F
S
R
V
S
L
Site 99
S1398
L
K
K
S
F
Y
G
S
T
L
F
L
C
R
R
Site 100
T1407
L
F
L
C
R
R
P
T
P
Q
D
S
P
I
F
Site 101
S1411
R
R
P
T
P
Q
D
S
P
I
F
L
P
V
D
Site 102
S1421
F
L
P
V
D
D
T
S
F
R
W
V
E
S
L
Site 103
S1427
T
S
F
R
W
V
E
S
L
K
G
I
L
A
D
Site 104
S1437
G
I
L
A
D
E
D
S
S
R
P
V
W
L
K
Site 105
S1438
I
L
A
D
E
D
S
S
R
P
V
W
L
K
A
Site 106
S1475
R
L
R
C
V
L
L
S
N
L
S
S
T
S
H
Site 107
S1481
L
S
N
L
S
S
T
S
H
V
P
E
V
D
P
Site 108
S1490
V
P
E
V
D
P
G
S
A
E
L
Q
K
V
L
Site 109
Y1506
G
D
L
V
M
N
V
Y
R
D
G
A
W
G
A
Site 110
S1542
T
L
T
R
G
D
L
S
S
I
R
W
V
C
S
Site 111
S1543
L
T
R
G
D
L
S
S
I
R
W
V
C
S
S
Site 112
S1550
S
I
R
W
V
C
S
S
L
R
H
A
Q
P
T
Site 113
T1557
S
L
R
H
A
Q
P
T
C
P
G
A
Q
L
C
Site 114
S1584
M
L
A
T
G
K
L
S
P
D
A
I
P
G
K
Site 115
S1594
A
I
P
G
K
W
T
S
Q
D
S
L
L
G
M
Site 116
S1597
G
K
W
T
S
Q
D
S
L
L
G
M
E
F
S
Site 117
S1604
S
L
L
G
M
E
F
S
G
R
D
A
S
G
K
Site 118
S1609
E
F
S
G
R
D
A
S
G
K
R
V
M
G
L
Site 119
S1675
G
E
T
L
L
I
H
S
G
S
G
G
V
G
Q
Site 120
T1698
L
G
C
R
V
F
T
T
V
G
S
A
E
K
R
Site 121
Y1707
G
S
A
E
K
R
A
Y
L
Q
A
R
F
P
Q
Site 122
S1717
A
R
F
P
Q
L
D
S
T
S
F
A
N
S
R
Site 123
T1718
R
F
P
Q
L
D
S
T
S
F
A
N
S
R
D
Site 124
S1719
F
P
Q
L
D
S
T
S
F
A
N
S
R
D
T
Site 125
S1723
D
S
T
S
F
A
N
S
R
D
T
S
F
E
Q
Site 126
T1726
S
F
A
N
S
R
D
T
S
F
E
Q
H
V
L
Site 127
S1727
F
A
N
S
R
D
T
S
F
E
Q
H
V
L
W
Site 128
S1756
A
E
E
K
L
Q
A
S
V
R
C
L
A
T
H
Site 129
S1775
E
I
G
K
F
D
L
S
Q
N
H
P
L
G
M
Site 130
Y1842
Q
V
E
D
A
F
R
Y
M
A
Q
G
K
H
I
Site 131
T1915
G
V
Q
K
L
V
L
T
S
R
S
G
I
R
T
Site 132
S1918
K
L
V
L
T
S
R
S
G
I
R
T
G
Y
Q
Site 133
T1922
T
S
R
S
G
I
R
T
G
Y
Q
A
K
Q
V
Site 134
Y1924
R
S
G
I
R
T
G
Y
Q
A
K
Q
V
R
R
Site 135
S1942
Q
G
V
Q
V
Q
V
S
T
S
N
I
S
S
L
Site 136
S1944
V
Q
V
Q
V
S
T
S
N
I
S
S
L
E
G
Site 137
S1947
Q
V
S
T
S
N
I
S
S
L
E
G
A
R
G
Site 138
S1948
V
S
T
S
N
I
S
S
L
E
G
A
R
G
L
Site 139
T1984
D
G
L
L
E
N
Q
T
P
E
F
F
Q
D
V
Site 140
Y1996
Q
D
V
C
K
P
K
Y
S
G
T
L
N
L
D
Site 141
T1999
C
K
P
K
Y
S
G
T
L
N
L
D
R
V
T
Site 142
T2006
T
L
N
L
D
R
V
T
R
E
A
C
P
E
L
Site 143
S2032
G
R
G
N
A
G
Q
S
N
Y
G
F
A
N
S
Site 144
Y2034
G
N
A
G
Q
S
N
Y
G
F
A
N
S
A
M
Site 145
T2078
E
T
M
S
T
N
D
T
I
V
S
G
T
L
P
Site 146
S2123
A
A
Y
R
D
R
D
S
Q
R
D
L
V
E
A
Site 147
T2165
M
S
V
E
V
R
Q
T
L
E
R
E
L
N
L
Site 148
S2175
R
E
L
N
L
V
L
S
V
R
E
V
R
Q
L
Site 149
T2183
V
R
E
V
R
Q
L
T
L
R
K
L
Q
E
L
Site 150
S2192
R
K
L
Q
E
L
S
S
K
A
D
E
A
S
E
Site 151
S2198
S
S
K
A
D
E
A
S
E
L
A
C
P
T
P
Site 152
T2204
A
S
E
L
A
C
P
T
P
K
E
D
G
L
A
Site 153
T2215
D
G
L
A
Q
Q
Q
T
Q
L
N
L
R
S
L
Site 154
S2221
Q
T
Q
L
N
L
R
S
L
L
V
N
P
E
G
Site 155
S2236
P
T
L
M
R
L
N
S
V
Q
S
S
E
R
P
Site 156
S2239
M
R
L
N
S
V
Q
S
S
E
R
P
L
F
L
Site 157
S2240
R
L
N
S
V
Q
S
S
E
R
P
L
F
L
V
Site 158
T2255
H
P
I
E
G
S
T
T
V
F
H
S
L
A
S
Site 159
S2265
H
S
L
A
S
R
L
S
I
P
T
Y
G
L
Q
Site 160
Y2269
S
R
L
S
I
P
T
Y
G
L
Q
C
T
R
A
Site 161
S2326
S
Q
L
Q
A
Q
Q
S
P
A
P
T
H
N
S
Site 162
T2330
A
Q
Q
S
P
A
P
T
H
N
S
L
F
L
F
Site 163
S2333
S
P
A
P
T
H
N
S
L
F
L
F
D
G
S
Site 164
Y2343
L
F
D
G
S
P
T
Y
V
L
A
Y
T
Q
S
Site 165
S2350
Y
V
L
A
Y
T
Q
S
Y
R
A
K
L
T
P
Site 166
T2356
Q
S
Y
R
A
K
L
T
P
G
C
E
A
E
A
Site 167
S2407
A
V
D
L
I
I
K
S
H
Q
G
L
D
R
Q
Site 168
S2417
G
L
D
R
Q
E
L
S
F
A
A
R
S
F
Y
Site 169
S2422
E
L
S
F
A
A
R
S
F
Y
Y
K
L
R
A
Site 170
Y2424
S
F
A
A
R
S
F
Y
Y
K
L
R
A
A
E
Site 171
Y2425
F
A
A
R
S
F
Y
Y
K
L
R
A
A
E
Q
Site 172
Y2433
K
L
R
A
A
E
Q
Y
T
P
K
A
K
Y
H
Site 173
T2434
L
R
A
A
E
Q
Y
T
P
K
A
K
Y
H
G
Site 174
Y2439
Q
Y
T
P
K
A
K
Y
H
G
N
V
M
L
L
Site 175
T2450
V
M
L
L
R
A
K
T
G
G
A
Y
G
E
D
Site 176
Y2454
R
A
K
T
G
G
A
Y
G
E
D
L
G
A
D
Site 177
Y2462
G
E
D
L
G
A
D
Y
N
L
S
Q
V
C
D
Site 178
S2465
L
G
A
D
Y
N
L
S
Q
V
C
D
G
K
V
Site 179
S2473
Q
V
C
D
G
K
V
S
V
H
V
I
E
G
D
Site 180
T2483
V
I
E
G
D
H
R
T
L
L
E
G
S
G
L
Site 181
S2488
H
R
T
L
L
E
G
S
G
L
E
S
I
I
S
Site 182
S2499
S
I
I
S
I
I
H
S
S
L
A
E
P
R
V
Site 183
S2507
S
L
A
E
P
R
V
S
V
R
E
G
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation