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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POU3F4
Full Name:
POU domain, class 3, transcription factor 4
Alias:
Brain 4; Brain-4; Brn4; Dfn3; Dfnx2; Otf9; Po3f4; Pou class 3 homeobox 4; Pou domain, class 3, transcription factor 4; Pou3f4
Type:
Nucleus protein; Transcription protein
Mass (Da):
39427
Number AA:
361
UniProt ID:
P49335
International Prot ID:
IPI00026790
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0007605
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
A
A
S
N
P
Y
S
I
L
S
S
T
S
L
Site 2
S13
S
N
P
Y
S
I
L
S
S
T
S
L
V
H
A
Site 3
S14
N
P
Y
S
I
L
S
S
T
S
L
V
H
A
D
Site 4
S22
T
S
L
V
H
A
D
S
A
G
M
Q
Q
G
S
Site 5
S29
S
A
G
M
Q
Q
G
S
P
F
R
N
P
Q
K
Site 6
Y42
Q
K
L
L
Q
S
D
Y
L
Q
G
V
P
S
N
Site 7
S48
D
Y
L
Q
G
V
P
S
N
G
H
P
L
G
H
Site 8
S62
H
H
W
V
T
S
L
S
D
G
G
P
W
S
S
Site 9
S68
L
S
D
G
G
P
W
S
S
T
L
A
T
S
P
Site 10
S69
S
D
G
G
P
W
S
S
T
L
A
T
S
P
L
Site 11
T70
D
G
G
P
W
S
S
T
L
A
T
S
P
L
D
Site 12
T73
P
W
S
S
T
L
A
T
S
P
L
D
Q
Q
D
Site 13
S74
W
S
S
T
L
A
T
S
P
L
D
Q
Q
D
V
Site 14
S98
G
A
I
I
H
H
R
S
P
H
V
A
H
H
S
Site 15
S105
S
P
H
V
A
H
H
S
P
H
T
N
H
P
N
Site 16
T108
V
A
H
H
S
P
H
T
N
H
P
N
A
W
G
Site 17
S117
H
P
N
A
W
G
A
S
P
A
P
N
P
S
I
Site 18
S123
A
S
P
A
P
N
P
S
I
T
S
S
G
Q
P
Site 19
T125
P
A
P
N
P
S
I
T
S
S
G
Q
P
L
N
Site 20
S127
P
N
P
S
I
T
S
S
G
Q
P
L
N
V
Y
Site 21
Y134
S
G
Q
P
L
N
V
Y
S
Q
P
G
F
T
V
Site 22
S135
G
Q
P
L
N
V
Y
S
Q
P
G
F
T
V
S
Site 23
S142
S
Q
P
G
F
T
V
S
G
M
L
E
H
G
G
Site 24
T151
M
L
E
H
G
G
L
T
P
P
P
A
A
A
S
Site 25
S158
T
P
P
P
A
A
A
S
A
Q
S
L
H
P
V
Site 26
S161
P
A
A
A
S
A
Q
S
L
H
P
V
L
R
E
Site 27
S184
S
H
H
C
Q
D
H
S
D
E
E
T
P
T
S
Site 28
T188
Q
D
H
S
D
E
E
T
P
T
S
D
E
L
E
Site 29
T190
H
S
D
E
E
T
P
T
S
D
E
L
E
Q
F
Site 30
S191
S
D
E
E
T
P
T
S
D
E
L
E
Q
F
A
Site 31
S241
R
F
E
G
L
Q
L
S
F
K
N
M
C
K
L
Site 32
S261
K
W
L
E
E
A
D
S
S
T
G
S
P
T
S
Site 33
S262
W
L
E
E
A
D
S
S
T
G
S
P
T
S
I
Site 34
T263
L
E
E
A
D
S
S
T
G
S
P
T
S
I
D
Site 35
S265
E
A
D
S
S
T
G
S
P
T
S
I
D
K
I
Site 36
T267
D
S
S
T
G
S
P
T
S
I
D
K
I
A
A
Site 37
S268
S
S
T
G
S
P
T
S
I
D
K
I
A
A
Q
Site 38
T283
G
R
K
R
K
K
R
T
S
I
E
V
S
V
K
Site 39
S284
R
K
R
K
K
R
T
S
I
E
V
S
V
K
G
Site 40
S288
K
R
T
S
I
E
V
S
V
K
G
V
L
E
T
Site 41
S314
E
I
S
S
L
A
D
S
L
Q
L
E
K
E
V
Site 42
T337
R
Q
K
E
K
R
M
T
P
P
G
D
Q
Q
P
Site 43
T351
P
H
E
V
Y
S
H
T
V
K
T
D
T
S
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation