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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
amphiphysin
Full Name:
Amphiphysin
Alias:
AMPH; AMPH1
Type:
Vesicle protein
Mass (Da):
76257
Number AA:
695
UniProt ID:
P49418
International Prot ID:
IPI00305486
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0030054
GO:0008021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
D
I
K
T
G
I
F
A
K
N
V
Site 2
T34
K
L
G
K
A
D
E
T
K
D
E
Q
F
E
E
Site 3
Y42
K
D
E
Q
F
E
E
Y
V
Q
N
F
K
R
Q
Site 4
Y63
L
Q
R
E
L
R
G
Y
L
A
A
I
K
G
M
Site 5
T78
Q
E
A
S
M
K
L
T
E
S
L
H
E
V
Y
Site 6
S80
A
S
M
K
L
T
E
S
L
H
E
V
Y
E
P
Site 7
Y85
T
E
S
L
H
E
V
Y
E
P
D
W
Y
G
R
Site 8
Y90
E
V
Y
E
P
D
W
Y
G
R
E
D
V
K
M
Site 9
S139
K
N
R
I
A
K
R
S
R
K
L
V
D
Y
D
Site 10
Y145
R
S
R
K
L
V
D
Y
D
S
A
R
H
H
L
Site 11
S147
R
K
L
V
D
Y
D
S
A
R
H
H
L
E
A
Site 12
S157
H
H
L
E
A
L
Q
S
S
K
R
K
D
E
S
Site 13
S158
H
L
E
A
L
Q
S
S
K
R
K
D
E
S
R
Site 14
S164
S
S
K
R
K
D
E
S
R
I
S
K
A
E
E
Site 15
S167
R
K
D
E
S
R
I
S
K
A
E
E
E
F
Q
Site 16
S193
D
L
Q
E
E
L
P
S
L
W
S
R
R
V
G
Site 17
S196
E
E
L
P
S
L
W
S
R
R
V
G
F
Y
V
Site 18
Y202
W
S
R
R
V
G
F
Y
V
N
T
F
K
N
V
Site 19
S211
N
T
F
K
N
V
S
S
L
E
A
K
F
H
K
Site 20
S250
F
T
I
Q
G
A
P
S
D
S
G
P
L
R
I
Site 21
S252
I
Q
G
A
P
S
D
S
G
P
L
R
I
A
K
Site 22
T260
G
P
L
R
I
A
K
T
P
S
P
P
E
E
P
Site 23
S262
L
R
I
A
K
T
P
S
P
P
E
E
P
S
P
Site 24
S268
P
S
P
P
E
E
P
S
P
L
P
S
P
T
A
Site 25
S272
E
E
P
S
P
L
P
S
P
T
A
S
P
N
H
Site 26
T274
P
S
P
L
P
S
P
T
A
S
P
N
H
T
L
Site 27
S276
P
L
P
S
P
T
A
S
P
N
H
T
L
A
P
Site 28
T280
P
T
A
S
P
N
H
T
L
A
P
A
S
P
A
Site 29
S285
N
H
T
L
A
P
A
S
P
A
P
A
R
P
R
Site 30
S293
P
A
P
A
R
P
R
S
P
S
Q
T
R
K
G
Site 31
S295
P
A
R
P
R
S
P
S
Q
T
R
K
G
P
P
Site 32
T297
R
P
R
S
P
S
Q
T
R
K
G
P
P
V
P
Site 33
T310
V
P
P
L
P
K
V
T
P
T
K
E
L
Q
Q
Site 34
T312
P
L
P
K
V
T
P
T
K
E
L
Q
Q
E
N
Site 35
S333
D
N
F
V
P
E
I
S
V
T
T
P
S
Q
N
Site 36
T335
F
V
P
E
I
S
V
T
T
P
S
Q
N
E
V
Site 37
T336
V
P
E
I
S
V
T
T
P
S
Q
N
E
V
P
Site 38
S338
E
I
S
V
T
T
P
S
Q
N
E
V
P
E
V
Site 39
T350
P
E
V
K
K
E
E
T
L
L
D
L
D
F
D
Site 40
T364
D
P
F
K
P
E
V
T
P
A
G
S
A
G
V
Site 41
S368
P
E
V
T
P
A
G
S
A
G
V
T
H
S
P
Site 42
T372
P
A
G
S
A
G
V
T
H
S
P
M
S
Q
T
Site 43
S374
G
S
A
G
V
T
H
S
P
M
S
Q
T
L
P
Site 44
S377
G
V
T
H
S
P
M
S
Q
T
L
P
W
D
L
Site 45
T386
T
L
P
W
D
L
W
T
T
S
T
D
L
V
Q
Site 46
T387
L
P
W
D
L
W
T
T
S
T
D
L
V
Q
P
Site 47
T389
W
D
L
W
T
T
S
T
D
L
V
Q
P
A
S
Site 48
S396
T
D
L
V
Q
P
A
S
G
G
S
F
N
G
F
Site 49
S399
V
Q
P
A
S
G
G
S
F
N
G
F
T
Q
P
Site 50
T404
G
G
S
F
N
G
F
T
Q
P
Q
D
T
S
L
Site 51
T433
E
S
E
Q
A
P
P
T
E
P
K
A
E
E
P
Site 52
T445
E
E
P
L
A
A
V
T
P
A
V
G
L
D
L
Site 53
T456
G
L
D
L
G
M
D
T
R
A
E
E
P
V
E
Site 54
T498
E
A
E
A
E
K
A
T
V
P
A
G
E
G
V
Site 55
S506
V
P
A
G
E
G
V
S
L
E
E
A
K
I
G
Site 56
S522
E
T
T
E
G
A
E
S
A
Q
P
E
A
E
E
Site 57
T533
E
A
E
E
L
E
A
T
V
P
Q
E
K
V
I
Site 58
S549
S
V
V
I
E
P
A
S
N
H
E
E
E
G
E
Site 59
T560
E
E
G
E
N
E
I
T
I
G
A
E
P
K
E
Site 60
T568
I
G
A
E
P
K
E
T
T
E
D
A
A
P
P
Site 61
S579
A
A
P
P
G
P
T
S
E
T
P
E
L
A
T
Site 62
T581
P
P
G
P
T
S
E
T
P
E
L
A
T
E
Q
Site 63
T597
P
I
Q
D
P
Q
P
T
P
S
A
P
A
M
G
Site 64
S599
Q
D
P
Q
P
T
P
S
A
P
A
M
G
A
A
Site 65
S611
G
A
A
D
Q
L
A
S
A
R
E
A
S
Q
E
Site 66
S616
L
A
S
A
R
E
A
S
Q
E
L
P
P
G
F
Site 67
Y625
E
L
P
P
G
F
L
Y
K
V
E
T
L
H
D
Site 68
S638
H
D
F
E
A
A
N
S
D
E
L
T
L
Q
R
Site 69
T642
A
A
N
S
D
E
L
T
L
Q
R
G
D
V
V
Site 70
S656
V
L
V
V
P
S
D
S
E
A
D
Q
D
A
G
Site 71
Y682
Q
Y
R
D
L
A
T
Y
K
G
L
F
P
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation