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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AARS
Full Name:
Alanyl-tRNA synthetase, cytoplasmic
Alias:
Alanine tRNA ligase 1, cytoplasmic; Alanine-tRNA ligase; Alanyl-tRNA synthetase; AlaRS; EC 6.1.1.7; NY-REN-42; SYA; SYAC
Type:
Enzyme, class-II aminoacyl-tRNA synthetase
Mass (Da):
106810
Number AA:
968
UniProt ID:
P49588
International Prot ID:
IPI00027442
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004813
GO:0000049
PhosphoSite+
KinaseNET
Biological Process:
GO:0006419
GO:0008033
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
D
S
T
L
T
A
S
E
I
R
Q
R
F
I
Site 2
T24
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
Site 3
Y25
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
Site 4
T56
F
K
P
I
F
L
N
T
I
D
P
S
H
P
M
Site 5
S60
F
L
N
T
I
D
P
S
H
P
M
A
K
L
S
Site 6
S67
S
H
P
M
A
K
L
S
R
A
A
N
T
Q
K
Site 7
T72
K
L
S
R
A
A
N
T
Q
K
C
I
R
A
G
Site 8
Y93
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
Site 9
T96
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
Site 10
Y109
G
S
W
S
F
G
D
Y
F
K
E
L
A
C
K
Site 11
Y137
I
E
R
L
Y
V
T
Y
F
G
G
D
E
A
A
Site 12
T164
Q
N
L
G
L
D
D
T
K
I
L
P
G
N
M
Site 13
Y192
G
P
C
S
E
I
H
Y
D
R
I
G
G
R
D
Site 14
Y222
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
I
Site 15
S237
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
Site 16
S249
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
Site 17
S256
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
Site 18
Y266
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
Site 19
Y279
K
G
T
G
A
R
P
Y
T
G
K
V
G
A
E
Site 20
T280
G
T
G
A
R
P
Y
T
G
K
V
G
A
E
D
Site 21
T318
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
Site 22
Y322
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
Site 23
T385
E
E
V
Q
F
L
K
T
L
S
R
G
R
R
I
Site 24
S387
V
Q
F
L
K
T
L
S
R
G
R
R
I
L
D
Site 25
S399
I
L
D
R
K
I
Q
S
L
G
D
S
K
T
I
Site 26
S403
K
I
Q
S
L
G
D
S
K
T
I
P
G
D
T
Site 27
T405
Q
S
L
G
D
S
K
T
I
P
G
D
T
A
W
Site 28
S452
R
K
L
A
Q
L
K
S
Q
G
K
G
A
G
G
Site 29
T481
R
A
R
G
L
E
V
T
D
D
S
P
K
Y
N
Site 30
S484
G
L
E
V
T
D
D
S
P
K
Y
N
Y
H
L
Site 31
Y487
V
T
D
D
S
P
K
Y
N
Y
H
L
D
S
S
Site 32
Y489
D
D
S
P
K
Y
N
Y
H
L
D
S
S
G
S
Site 33
S493
K
Y
N
Y
H
L
D
S
S
G
S
Y
V
F
E
Site 34
S496
Y
H
L
D
S
S
G
S
Y
V
F
E
N
T
V
Site 35
Y497
H
L
D
S
S
G
S
Y
V
F
E
N
T
V
A
Site 36
Y535
V
L
D
K
T
C
F
Y
A
E
Q
G
G
Q
I
Site 37
Y543
A
E
Q
G
G
Q
I
Y
D
E
G
Y
L
V
K
Site 38
Y547
G
Q
I
Y
D
E
G
Y
L
V
K
V
D
D
S
Site 39
S554
Y
L
V
K
V
D
D
S
S
E
D
K
T
E
F
Site 40
S555
L
V
K
V
D
D
S
S
E
D
K
T
E
F
T
Site 41
T559
D
D
S
S
E
D
K
T
E
F
T
V
K
N
A
Site 42
T578
G
Y
V
L
H
I
G
T
I
Y
G
D
L
K
V
Site 43
Y580
V
L
H
I
G
T
I
Y
G
D
L
K
V
G
D
Site 44
S603
P
R
R
R
P
I
M
S
N
H
T
A
T
H
I
Site 45
S627
G
E
A
D
Q
K
G
S
L
V
A
P
D
R
L
Site 46
T639
D
R
L
R
F
D
F
T
A
K
G
A
M
S
T
Site 47
Y667
I
E
A
A
K
A
V
Y
T
Q
D
C
P
L
A
Site 48
T689
L
R
A
V
F
D
E
T
Y
P
D
P
V
R
V
Site 49
Y690
R
A
V
F
D
E
T
Y
P
D
P
V
R
V
V
Site 50
S711
S
E
L
L
D
D
P
S
G
P
A
G
S
L
T
Site 51
S716
D
P
S
G
P
A
G
S
L
T
S
V
E
F
C
Site 52
T726
S
V
E
F
C
G
G
T
H
L
R
N
S
S
H
Site 53
S731
G
G
T
H
L
R
N
S
S
H
A
G
A
F
V
Site 54
S732
G
T
H
L
R
N
S
S
H
A
G
A
F
V
I
Site 55
S769
K
A
L
R
K
A
E
S
L
K
K
C
L
S
V
Site 56
S775
E
S
L
K
K
C
L
S
V
M
E
A
K
V
K
Site 57
T818
Q
K
D
E
L
R
E
T
L
K
S
L
K
K
V
Site 58
S821
E
L
R
E
T
L
K
S
L
K
K
V
M
D
D
Site 59
S833
M
D
D
L
D
R
A
S
K
A
D
V
Q
K
R
Site 60
T845
Q
K
R
V
L
E
K
T
K
Q
F
I
D
S
N
Site 61
S851
K
T
K
Q
F
I
D
S
N
P
N
Q
P
L
V
Site 62
S882
L
K
L
F
K
M
H
S
P
Q
T
S
A
M
L
Site 63
S886
K
M
H
S
P
Q
T
S
A
M
L
F
T
V
D
Site 64
S917
A
N
R
G
L
K
A
S
E
W
V
Q
Q
V
S
Site 65
S924
S
E
W
V
Q
Q
V
S
G
L
M
D
G
K
G
Site 66
S937
K
G
G
G
K
D
V
S
A
Q
A
T
G
K
N
Site 67
T941
K
D
V
S
A
Q
A
T
G
K
N
V
G
C
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation