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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CysRS
Full Name:
Cysteinyl-tRNA synthetase, cytoplasmic
Alias:
CARS; CARS1; Cysteine tRNA ligase 1, cytoplasmic; Cysteine-tRNA ligase; Cysteine--tRNA ligase; Cysteinyl-tRNA synthetase; EC 6.1.1.16; SYC; SYCC
Type:
Enzyme, class-I aminoacyl-tRNA synthetase
Mass (Da):
85473
Number AA:
748
UniProt ID:
P49589
International Prot ID:
IPI00556365
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004817
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0006423
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
R
R
V
Q
P
Q
W
S
P
P
A
G
T
Q
P
Site 2
T24
Q
W
S
P
P
A
G
T
Q
P
C
R
L
H
L
Site 3
Y32
Q
P
C
R
L
H
L
Y
N
S
L
T
R
N
K
Site 4
S34
C
R
L
H
L
Y
N
S
L
T
R
N
K
E
V
Site 5
T36
L
H
L
Y
N
S
L
T
R
N
K
E
V
F
I
Site 6
Y53
D
G
K
K
V
T
W
Y
C
C
G
P
T
V
Y
Site 7
Y60
Y
C
C
G
P
T
V
Y
D
A
S
H
M
G
H
Site 8
S63
G
P
T
V
Y
D
A
S
H
M
G
H
A
R
S
Site 9
S70
S
H
M
G
H
A
R
S
Y
I
S
F
D
I
L
Site 10
Y71
H
M
G
H
A
R
S
Y
I
S
F
D
I
L
R
Site 11
S73
G
H
A
R
S
Y
I
S
F
D
I
L
R
R
V
Site 12
Y84
L
R
R
V
L
K
D
Y
F
K
F
D
V
F
Y
Site 13
S137
Q
A
A
L
K
P
F
S
V
K
L
N
E
T
T
Site 14
T175
K
A
V
Q
S
R
L
T
G
E
E
V
N
S
C
Site 15
S195
E
E
A
K
D
L
L
S
D
W
L
D
S
T
L
Site 16
T201
L
S
D
W
L
D
S
T
L
G
C
D
V
T
D
Site 17
T207
S
T
L
G
C
D
V
T
D
N
S
I
F
S
K
Site 18
S210
G
C
D
V
T
D
N
S
I
F
S
K
L
P
K
Site 19
T239
V
L
P
P
D
V
L
T
R
V
S
E
Y
V
P
Site 20
Y260
Q
K
I
V
D
N
G
Y
G
Y
V
S
N
G
S
Site 21
Y262
I
V
D
N
G
Y
G
Y
V
S
N
G
S
V
Y
Site 22
S267
Y
G
Y
V
S
N
G
S
V
Y
F
D
T
A
K
Site 23
Y269
Y
V
S
N
G
S
V
Y
F
D
T
A
K
F
A
Site 24
T272
N
G
S
V
Y
F
D
T
A
K
F
A
S
S
E
Site 25
S278
D
T
A
K
F
A
S
S
E
K
H
S
Y
G
K
Site 26
S282
F
A
S
S
E
K
H
S
Y
G
K
L
V
P
E
Site 27
Y283
A
S
S
E
K
H
S
Y
G
K
L
V
P
E
A
Site 28
S305
Q
E
G
E
G
D
L
S
I
S
A
D
R
L
S
Site 29
S307
G
E
G
D
L
S
I
S
A
D
R
L
S
E
K
Site 30
S312
S
I
S
A
D
R
L
S
E
K
R
S
P
N
D
Site 31
S316
D
R
L
S
E
K
R
S
P
N
D
F
A
L
W
Site 32
S326
D
F
A
L
W
K
A
S
K
P
G
E
P
S
W
Site 33
S332
A
S
K
P
G
E
P
S
W
P
C
P
W
G
K
Site 34
S381
H
D
N
E
L
A
Q
S
E
A
Y
F
E
N
D
Site 35
Y384
E
L
A
Q
S
E
A
Y
F
E
N
D
C
W
V
Site 36
T416
K
S
L
K
N
F
I
T
I
K
D
A
L
K
K
Site 37
S425
K
D
A
L
K
K
H
S
A
R
Q
L
R
L
A
Site 38
T441
L
M
H
S
W
K
D
T
L
D
Y
S
S
N
T
Site 39
Y444
S
W
K
D
T
L
D
Y
S
S
N
T
M
E
S
Site 40
S445
W
K
D
T
L
D
Y
S
S
N
T
M
E
S
A
Site 41
S446
K
D
T
L
D
Y
S
S
N
T
M
E
S
A
L
Site 42
Y455
T
M
E
S
A
L
Q
Y
E
K
F
L
N
E
F
Site 43
T477
L
R
A
P
V
D
I
T
G
Q
F
E
K
W
G
Site 44
Y495
A
E
L
N
K
N
F
Y
D
K
K
T
A
I
H
Site 45
T499
K
N
F
Y
D
K
K
T
A
I
H
K
A
L
C
Site 46
T513
C
D
N
V
D
T
R
T
V
M
E
E
M
R
A
Site 47
Y528
L
V
S
Q
C
N
L
Y
M
A
A
R
K
A
V
Site 48
S566
G
A
V
E
E
D
S
S
L
G
F
P
V
G
G
Site 49
S592
M
P
Y
L
Q
V
L
S
E
F
R
E
G
V
R
Site 50
T637
E
D
H
E
G
L
P
T
V
V
K
L
V
D
R
Site 51
T646
V
K
L
V
D
R
N
T
L
L
K
E
R
E
E
Site 52
S688
A
K
M
K
I
P
P
S
E
M
F
L
S
E
T
Site 53
S693
P
P
S
E
M
F
L
S
E
T
D
K
Y
S
K
Site 54
T695
S
E
M
F
L
S
E
T
D
K
Y
S
K
F
D
Site 55
Y698
F
L
S
E
T
D
K
Y
S
K
F
D
E
N
G
Site 56
S746
L
Q
M
A
Q
N
G
S
F
Q
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation