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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAN2A2
Full Name:
Alpha-mannosidase 2x
Alias:
Alpha-mannosidase IIx; EC 3.2.1.114; MA2A2; MAN IIx; MANA2X; Mannosidase alpha class 2A member 2; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Type:
Membrane, Integral membrane, Golgi apparatus protein
Mass (Da):
129282
Number AA:
1139
UniProt ID:
P49641
International Prot ID:
IPI00027703
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004559
GO:0030246
GO:0004572
PhosphoSite+
KinaseNET
Biological Process:
GO:0006013
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
D
R
V
Q
H
D
P
T
R
H
Q
N
G
G
N
Site 2
S45
N
G
G
N
F
P
R
S
Q
I
S
V
L
Q
N
Site 3
T79
K
D
S
V
L
E
L
T
A
N
A
E
G
P
P
Site 4
Y91
G
P
P
A
M
L
P
Y
Y
T
V
N
G
S
W
Site 5
S97
P
Y
Y
T
V
N
G
S
W
V
V
P
P
E
P
Site 6
S107
V
P
P
E
P
R
P
S
F
F
S
I
S
P
Q
Site 7
S110
E
P
R
P
S
F
F
S
I
S
P
Q
D
C
Q
Site 8
S112
R
P
S
F
F
S
I
S
P
Q
D
C
Q
F
A
Site 9
T133
K
P
E
L
Q
M
L
T
V
S
E
E
L
P
F
Site 10
Y156
R
Q
G
F
D
I
S
Y
D
P
H
D
W
D
A
Site 11
T183
N
D
P
G
W
I
K
T
F
D
K
Y
Y
T
E
Site 12
Y188
I
K
T
F
D
K
Y
Y
T
E
Q
T
Q
H
I
Site 13
S198
Q
T
Q
H
I
L
N
S
M
V
S
K
L
Q
E
Site 14
Y260
P
D
E
A
N
S
H
Y
F
A
L
I
D
Q
L
Site 15
T281
L
E
R
N
L
G
A
T
P
R
S
G
W
A
V
Site 16
S284
N
L
G
A
T
P
R
S
G
W
A
V
D
P
F
Site 17
S295
V
D
P
F
G
Y
S
S
T
M
P
Y
L
L
R
Site 18
T296
D
P
F
G
Y
S
S
T
M
P
Y
L
L
R
R
Site 19
Y299
G
Y
S
S
T
M
P
Y
L
L
R
R
A
N
L
Site 20
S308
L
R
R
A
N
L
T
S
M
L
I
Q
R
V
H
Site 21
T359
Y
S
Y
D
V
P
H
T
C
G
P
D
P
K
I
Site 22
T392
K
V
P
P
R
A
I
T
E
A
N
V
A
E
R
Site 23
Y407
A
A
L
L
L
D
Q
Y
R
K
K
S
Q
L
F
Site 24
S411
L
D
Q
Y
R
K
K
S
Q
L
F
R
S
N
V
Site 25
Y429
P
L
G
D
D
F
R
Y
D
K
P
Q
E
W
D
Site 26
S451
R
L
F
D
F
F
N
S
R
P
N
L
H
V
Q
Site 27
S465
Q
A
Q
F
G
T
L
S
D
Y
F
D
A
L
Y
Site 28
Y467
Q
F
G
T
L
S
D
Y
F
D
A
L
Y
K
R
Site 29
Y472
S
D
Y
F
D
A
L
Y
K
R
T
G
V
E
P
Site 30
S495
V
L
S
G
D
F
F
S
Y
A
D
R
E
D
H
Site 31
Y496
L
S
G
D
F
F
S
Y
A
D
R
E
D
H
Y
Site 32
Y503
Y
A
D
R
E
D
H
Y
W
T
G
Y
Y
T
S
Site 33
Y507
E
D
H
Y
W
T
G
Y
Y
T
S
R
P
F
Y
Site 34
Y508
D
H
Y
W
T
G
Y
Y
T
S
R
P
F
Y
K
Site 35
Y514
Y
Y
T
S
R
P
F
Y
K
S
L
D
R
V
L
Site 36
S516
T
S
R
P
F
Y
K
S
L
D
R
V
L
E
A
Site 37
S542
A
A
A
H
A
R
R
S
G
L
A
G
R
Y
P
Site 38
Y548
R
S
G
L
A
G
R
Y
P
L
S
D
F
T
L
Site 39
T554
R
Y
P
L
S
D
F
T
L
L
T
E
A
R
R
Site 40
T557
L
S
D
F
T
L
L
T
E
A
R
R
T
L
G
Site 41
T562
L
L
T
E
A
R
R
T
L
G
L
F
Q
H
H
Site 42
T613
L
V
L
G
D
K
E
T
Y
H
F
D
P
E
A
Site 43
T628
P
F
L
Q
V
D
D
T
R
L
S
H
D
A
L
Site 44
S631
Q
V
D
D
T
R
L
S
H
D
A
L
P
E
R
Site 45
S665
Q
E
R
F
S
M
V
S
L
L
V
N
S
P
R
Site 46
S677
S
P
R
V
R
V
L
S
E
E
G
Q
P
L
A
Site 47
S688
Q
P
L
A
V
Q
I
S
A
H
W
S
S
A
T
Site 48
S692
V
Q
I
S
A
H
W
S
S
A
T
E
A
V
P
Site 49
T729
L
G
L
D
G
H
R
T
L
P
S
S
V
R
I
Site 50
S732
D
G
H
R
T
L
P
S
S
V
R
I
Y
L
H
Site 51
S733
G
H
R
T
L
P
S
S
V
R
I
Y
L
H
G
Site 52
Y737
L
P
S
S
V
R
I
Y
L
H
G
R
Q
L
S
Site 53
S744
Y
L
H
G
R
Q
L
S
V
S
R
H
E
A
F
Site 54
S746
H
G
R
Q
L
S
V
S
R
H
E
A
F
P
L
Site 55
T760
L
R
V
I
D
S
G
T
S
D
F
A
L
S
N
Site 56
S783
G
L
T
G
L
L
K
S
I
R
R
V
D
E
E
Site 57
Y802
V
D
M
Q
V
L
V
Y
G
T
R
T
S
K
D
Site 58
S807
L
V
Y
G
T
R
T
S
K
D
K
S
G
A
Y
Site 59
S811
T
R
T
S
K
D
K
S
G
A
Y
L
F
L
P
Site 60
S823
F
L
P
D
G
E
A
S
P
T
S
P
R
S
P
Site 61
T825
P
D
G
E
A
S
P
T
S
P
R
S
P
P
C
Site 62
S826
D
G
E
A
S
P
T
S
P
R
S
P
P
C
C
Site 63
S829
A
S
P
T
S
P
R
S
P
P
C
C
V
S
L
Site 64
S835
R
S
P
P
C
C
V
S
L
K
A
L
S
S
Q
Site 65
S841
V
S
L
K
A
L
S
S
Q
R
W
L
R
T
M
Site 66
T847
S
S
Q
R
W
L
R
T
M
S
T
F
T
R
R
Site 67
S849
Q
R
W
L
R
T
M
S
T
F
T
R
R
S
G
Site 68
T850
R
W
L
R
T
M
S
T
F
T
R
R
S
G
F
Site 69
S855
M
S
T
F
T
R
R
S
G
F
T
I
C
Q
G
Site 70
S883
S
G
T
T
S
T
R
S
W
P
C
T
S
I
Q
Site 71
T887
S
T
R
S
W
P
C
T
S
I
Q
T
S
T
A
Site 72
S888
T
R
S
W
P
C
T
S
I
Q
T
S
T
A
R
Site 73
S892
P
C
T
S
I
Q
T
S
T
A
R
V
Q
P
R
Site 74
T893
C
T
S
I
Q
T
S
T
A
R
V
Q
P
R
R
Site 75
Y901
A
R
V
Q
P
R
R
Y
L
K
K
L
P
L
Q
Site 76
T928
Q
D
A
Q
K
R
L
T
L
H
T
A
Q
A
L
Site 77
T931
Q
K
R
L
T
L
H
T
A
Q
A
L
G
V
S
Site 78
S939
A
Q
A
L
G
V
S
S
L
K
D
G
Q
L
E
Site 79
T983
R
L
L
L
E
R
R
T
V
G
S
E
V
Q
D
Site 80
S986
L
E
R
R
T
V
G
S
E
V
Q
D
S
H
S
Site 81
S991
V
G
S
E
V
Q
D
S
H
S
T
S
Y
P
S
Site 82
S993
S
E
V
Q
D
S
H
S
T
S
Y
P
S
L
L
Site 83
T994
E
V
Q
D
S
H
S
T
S
Y
P
S
L
L
S
Site 84
S995
V
Q
D
S
H
S
T
S
Y
P
S
L
L
S
H
Site 85
Y996
Q
D
S
H
S
T
S
Y
P
S
L
L
S
H
L
Site 86
S998
S
H
S
T
S
Y
P
S
L
L
S
H
L
T
S
Site 87
S1029
L
P
G
P
G
L
R
S
F
H
P
L
A
S
S
Site 88
S1035
R
S
F
H
P
L
A
S
S
L
P
C
D
F
H
Site 89
S1117
T
L
L
Y
P
L
A
S
P
S
N
S
T
D
V
Site 90
S1119
L
Y
P
L
A
S
P
S
N
S
T
D
V
Y
L
Site 91
S1121
P
L
A
S
P
S
N
S
T
D
V
Y
L
E
P
Site 92
Y1125
P
S
N
S
T
D
V
Y
L
E
P
M
E
I
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation