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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRIM1
Full Name:
DNA primase small subunit
Alias:
DNA primase 1; DNA primase 49 kDa subunit; PRI1; Primase, DNA, polypeptide 1
Type:
DNA replication; Transferase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 2.7.7.-
Mass (Da):
49902
Number AA:
420
UniProt ID:
P49642
International Prot ID:
IPI00027704
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005658
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003896
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006269
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
E
T
F
D
P
T
E
L
P
Site 2
T7
_
M
E
T
F
D
P
T
E
L
P
E
L
L
K
Site 3
Y16
L
P
E
L
L
K
L
Y
Y
R
R
L
F
P
Y
Site 4
Y17
P
E
L
L
K
L
Y
Y
R
R
L
F
P
Y
S
Site 5
Y23
Y
Y
R
R
L
F
P
Y
S
Q
Y
Y
R
W
L
Site 6
Y26
R
L
F
P
Y
S
Q
Y
Y
R
W
L
N
Y
G
Site 7
Y32
Q
Y
Y
R
W
L
N
Y
G
G
V
I
K
N
Y
Site 8
Y39
Y
G
G
V
I
K
N
Y
F
Q
H
R
E
F
S
Site 9
S46
Y
F
Q
H
R
E
F
S
F
T
L
K
D
D
I
Site 10
T48
Q
H
R
E
F
S
F
T
L
K
D
D
I
Y
I
Site 11
Y54
F
T
L
K
D
D
I
Y
I
R
Y
Q
S
F
N
Site 12
Y57
K
D
D
I
Y
I
R
Y
Q
S
F
N
N
Q
S
Site 13
Y76
E
M
Q
K
M
N
P
Y
K
I
D
I
G
A
V
Site 14
Y115
F
D
I
D
M
T
D
Y
D
D
V
R
R
C
C
Site 15
S123
D
D
V
R
R
C
C
S
S
A
D
I
C
P
K
Site 16
S124
D
V
R
R
C
C
S
S
A
D
I
C
P
K
C
Site 17
Y159
F
K
H
R
L
W
V
Y
S
G
R
R
G
V
H
Site 18
S178
D
E
S
V
R
K
L
S
S
A
V
R
S
G
I
Site 19
S179
E
S
V
R
K
L
S
S
A
V
R
S
G
I
V
Site 20
Y188
V
R
S
G
I
V
E
Y
L
S
L
V
K
G
G
Site 21
S190
S
G
I
V
E
Y
L
S
L
V
K
G
G
Q
D
Site 22
S205
V
K
K
K
V
H
L
S
E
K
I
H
P
F
I
Site 23
S239
D
I
L
E
N
K
E
S
W
D
K
I
L
A
L
Site 24
S258
I
H
D
E
L
Q
Q
S
F
Q
K
S
H
N
S
Site 25
S262
L
Q
Q
S
F
Q
K
S
H
N
S
L
Q
R
W
Site 26
S265
S
F
Q
K
S
H
N
S
L
Q
R
W
E
H
L
Site 27
S277
E
H
L
K
K
V
A
S
R
Y
Q
N
N
I
K
Site 28
Y288
N
N
I
K
N
D
K
Y
G
P
W
L
E
W
E
Site 29
S319
G
I
N
H
L
L
K
S
P
F
S
V
H
P
K
Site 30
S322
H
L
L
K
S
P
F
S
V
H
P
K
T
G
R
Site 31
T327
P
F
S
V
H
P
K
T
G
R
I
S
V
P
I
Site 32
S331
H
P
K
T
G
R
I
S
V
P
I
D
L
Q
K
Site 33
S361
C
R
E
L
D
A
I
S
T
N
E
E
E
K
E
Site 34
T362
R
E
L
D
A
I
S
T
N
E
E
E
K
E
E
Site 35
Y383
V
K
H
R
T
R
D
Y
K
K
T
S
L
A
P
Site 36
T386
R
T
R
D
Y
K
K
T
S
L
A
P
Y
V
K
Site 37
Y391
K
K
T
S
L
A
P
Y
V
K
V
F
E
H
F
Site 38
S405
F
L
E
N
L
D
K
S
R
K
G
E
L
L
K
Site 39
S414
K
G
E
L
L
K
K
S
D
L
Q
K
D
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation