KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PRIM2
Full Name:
DNA primase large subunit
Alias:
DNA primase 2A; DNA primase 58 kDa; DNA primase 58 kDa subunit; P58; PRIM2A; Primase, DNA, polypeptide 2
Type:
Transferase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 2.7.7.-
Mass (Da):
58806
Number AA:
509
UniProt ID:
P49643
International Prot ID:
IPI00027705
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005658
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0003677
GO:0003896
PhosphoSite+
KinaseNET
Biological Process:
GO:0006269
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
F
S
G
R
K
W
R
K
L
Site 2
S21
A
G
D
Q
R
N
A
S
Y
P
H
C
L
Q
F
Site 3
Y22
G
D
Q
R
N
A
S
Y
P
H
C
L
Q
F
Y
Site 4
Y29
Y
P
H
C
L
Q
F
Y
L
Q
P
P
S
E
N
Site 5
S34
Q
F
Y
L
Q
P
P
S
E
N
I
S
L
I
E
Site 6
S38
Q
P
P
S
E
N
I
S
L
I
E
F
E
N
L
Site 7
S55
D
R
V
K
L
L
K
S
V
E
N
L
G
V
S
Site 8
S62
S
V
E
N
L
G
V
S
Y
V
K
G
T
E
Q
Site 9
Y63
V
E
N
L
G
V
S
Y
V
K
G
T
E
Q
Y
Site 10
S72
K
G
T
E
Q
Y
Q
S
K
L
E
S
E
L
R
Site 11
S76
Q
Y
Q
S
K
L
E
S
E
L
R
K
L
K
F
Site 12
S84
E
L
R
K
L
K
F
S
Y
R
E
N
L
E
D
Site 13
Y93
R
E
N
L
E
D
E
Y
E
P
R
R
R
D
H
Site 14
S102
P
R
R
R
D
H
I
S
H
F
I
L
R
L
A
Site 15
Y110
H
F
I
L
R
L
A
Y
C
Q
S
E
E
L
R
Site 16
S113
L
R
L
A
Y
C
Q
S
E
E
L
R
R
W
F
Site 17
S133
D
L
L
R
F
R
F
S
I
L
P
K
D
K
I
Site 18
S147
I
Q
D
F
L
K
D
S
Q
L
Q
F
E
A
I
Site 19
S155
Q
L
Q
F
E
A
I
S
D
E
E
K
T
L
R
Site 20
T160
A
I
S
D
E
E
K
T
L
R
E
Q
E
I
V
Site 21
S169
R
E
Q
E
I
V
A
S
S
P
S
L
S
G
L
Site 22
S170
E
Q
E
I
V
A
S
S
P
S
L
S
G
L
K
Site 23
Y201
L
F
R
G
R
K
V
Y
L
E
D
G
F
A
Y
Site 24
Y208
Y
L
E
D
G
F
A
Y
V
P
L
K
D
I
V
Site 25
S242
R
S
L
P
A
V
Q
S
D
E
R
L
Q
P
L
Site 26
S254
Q
P
L
L
N
H
L
S
H
S
Y
T
G
Q
D
Site 27
T258
N
H
L
S
H
S
Y
T
G
Q
D
Y
S
T
Q
Site 28
Y262
H
S
Y
T
G
Q
D
Y
S
T
Q
G
N
V
G
Site 29
S263
S
Y
T
G
Q
D
Y
S
T
Q
G
N
V
G
K
Site 30
T264
Y
T
G
Q
D
Y
S
T
Q
G
N
V
G
K
I
Site 31
S280
L
D
Q
I
D
L
L
S
T
K
S
F
P
P
C
Site 32
T281
D
Q
I
D
L
L
S
T
K
S
F
P
P
C
M
Site 33
S283
I
D
L
L
S
T
K
S
F
P
P
C
M
R
Q
Site 34
Y309
R
H
G
G
R
M
Q
Y
G
L
F
L
K
G
I
Site 35
Y345
P
D
K
F
D
K
G
Y
S
Y
N
I
R
H
S
Site 36
Y347
K
F
D
K
G
Y
S
Y
N
I
R
H
S
F
G
Site 37
S352
Y
S
Y
N
I
R
H
S
F
G
K
E
G
K
R
Site 38
T360
F
G
K
E
G
K
R
T
D
Y
T
P
F
S
C
Site 39
Y362
K
E
G
K
R
T
D
Y
T
P
F
S
C
L
K
Site 40
T363
E
G
K
R
T
D
Y
T
P
F
S
C
L
K
I
Site 41
S373
S
C
L
K
I
I
L
S
N
P
P
S
Q
G
D
Site 42
S377
I
I
L
S
N
P
P
S
Q
G
D
Y
H
G
C
Site 43
Y381
N
P
P
S
Q
G
D
Y
H
G
C
P
F
R
H
Site 44
S389
H
G
C
P
F
R
H
S
D
P
E
L
L
K
Q
Site 45
S400
L
L
K
Q
K
L
Q
S
Y
K
I
S
P
G
G
Site 46
Y401
L
K
Q
K
L
Q
S
Y
K
I
S
P
G
G
I
Site 47
S404
K
L
Q
S
Y
K
I
S
P
G
G
I
S
Q
I
Site 48
Y420
D
L
V
K
G
T
H
Y
Q
V
A
C
Q
K
Y
Site 49
T470
K
E
P
I
Q
P
E
T
P
Q
P
K
P
S
V
Site 50
S476
E
T
P
Q
P
K
P
S
V
Q
K
T
K
D
A
Site 51
T480
P
K
P
S
V
Q
K
T
K
D
A
S
S
A
L
Site 52
S485
Q
K
T
K
D
A
S
S
A
L
A
S
L
N
S
Site 53
S489
D
A
S
S
A
L
A
S
L
N
S
S
L
E
M
Site 54
S492
S
A
L
A
S
L
N
S
S
L
E
M
D
M
E
Site 55
S493
A
L
A
S
L
N
S
S
L
E
M
D
M
E
G
Site 56
Y504
D
M
E
G
L
E
D
Y
F
S
E
D
S
_
_
Site 57
S509
E
D
Y
F
S
E
D
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation