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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASP4
Full Name:
Caspase-4
Alias:
CASP-4; Caspase 4, apoptosis-related cysteine peptidase; Caspase-4 2; EC 3.4.22.57; EC 3.4.22.64; ICE(rel)-II; ICEREL-II; ICH2; ICH-2; ICH-2 protease; Mih1/TX; TX; TX protease
Type:
Protease
Mass (Da):
43262
Number AA:
377
UniProt ID:
P49662
International Prot ID:
IPI00027725
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
GO:0004197
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006917
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
K
P
L
K
V
L
E
S
L
G
K
D
F
L
T
Site 2
Y45
K
E
E
E
K
K
K
Y
Y
D
A
K
T
E
D
Site 3
Y46
E
E
E
K
K
K
Y
Y
D
A
K
T
E
D
K
Site 4
T50
K
K
Y
Y
D
A
K
T
E
D
K
V
R
V
M
Site 5
S60
K
V
R
V
M
A
D
S
M
Q
E
K
Q
R
M
Site 6
S83
F
F
N
I
D
Q
I
S
P
N
K
K
A
H
P
Site 7
S99
M
E
A
G
P
P
E
S
G
E
S
T
D
A
L
Site 8
S102
G
P
P
E
S
G
E
S
T
D
A
L
K
L
C
Site 9
T103
P
P
E
S
G
E
S
T
D
A
L
K
L
C
P
Site 10
Y126
K
E
R
A
E
E
I
Y
P
I
K
E
R
N
N
Site 11
T160
N
G
A
D
F
D
I
T
G
M
K
E
L
L
E
Site 12
Y171
E
L
L
E
G
L
D
Y
S
V
D
V
E
E
N
Site 13
S172
L
L
E
G
L
D
Y
S
V
D
V
E
E
N
L
Site 14
T180
V
D
V
E
E
N
L
T
A
R
D
M
E
S
A
Site 15
S186
L
T
A
R
D
M
E
S
A
L
R
A
F
A
T
Site 16
T193
S
A
L
R
A
F
A
T
R
P
E
H
K
S
S
Site 17
S199
A
T
R
P
E
H
K
S
S
D
S
T
F
L
V
Site 18
S200
T
R
P
E
H
K
S
S
D
S
T
F
L
V
L
Site 19
S202
P
E
H
K
S
S
D
S
T
F
L
V
L
M
S
Site 20
T203
E
H
K
S
S
D
S
T
F
L
V
L
M
S
H
Site 21
S245
F
N
N
R
N
C
L
S
L
K
D
K
P
K
V
Site 22
S271
G
E
L
W
V
R
D
S
P
A
S
L
E
V
A
Site 23
S274
W
V
R
D
S
P
A
S
L
E
V
A
S
S
Q
Site 24
S280
A
S
L
E
V
A
S
S
Q
S
S
E
N
L
E
Site 25
S283
E
V
A
S
S
Q
S
S
E
N
L
E
E
D
A
Site 26
Y292
N
L
E
E
D
A
V
Y
K
T
H
V
E
K
D
Site 27
S305
K
D
F
I
A
F
C
S
S
T
P
H
N
V
S
Site 28
S312
S
S
T
P
H
N
V
S
W
R
D
S
T
M
G
Site 29
T317
N
V
S
W
R
D
S
T
M
G
S
I
F
I
T
Site 30
S349
V
F
R
K
V
Q
Q
S
F
E
T
P
R
A
K
Site 31
T352
K
V
Q
Q
S
F
E
T
P
R
A
K
A
Q
M
Site 32
Y370
E
R
L
S
M
T
R
Y
F
Y
L
F
P
G
N
Site 33
Y372
L
S
M
T
R
Y
F
Y
L
F
P
G
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation