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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rgs6
Full Name:
Regulator of G-protein signaling 6
Alias:
FLJ43552; Gap; Regulator of G protein signalling 6
Type:
Membrane, Cytoplasm, Heterotrimeric G-protein complex protein
Mass (Da):
54423
Number AA:
472
UniProt ID:
P49758
International Prot ID:
IPI00028060
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005834
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007242
GO:0009968
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
V
A
D
P
E
E
S
S
P
N
M
I
V
Y
C
Site 2
T34
C
K
I
E
D
I
I
T
K
M
Q
D
D
K
T
Site 3
T41
T
K
M
Q
D
D
K
T
G
G
V
P
I
R
T
Site 4
T48
T
G
G
V
P
I
R
T
V
K
S
F
L
S
K
Site 5
S74
Q
W
L
M
K
N
L
S
I
E
D
P
V
E
A
Site 6
T109
L
T
M
K
D
D
G
T
F
Y
R
F
Q
A
P
Site 7
Y111
M
K
D
D
G
T
F
Y
R
F
Q
A
P
Y
F
Site 8
Y131
W
E
P
E
N
T
D
Y
A
I
Y
L
C
K
R
Site 9
Y134
E
N
T
D
Y
A
I
Y
L
C
K
R
T
M
Q
Site 10
Y151
A
R
L
E
L
A
D
Y
E
A
E
N
L
A
R
Site 11
T187
I
D
R
K
K
D
K
T
E
R
K
I
L
D
S
Site 12
S194
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Site 13
S232
N
P
Q
K
V
K
K
S
V
Y
G
V
T
E
E
Site 14
S240
V
Y
G
V
T
E
E
S
Q
A
Q
S
P
V
H
Site 15
S244
T
E
E
S
Q
A
Q
S
P
V
H
V
L
S
Q
Site 16
S250
Q
S
P
V
H
V
L
S
Q
P
I
R
K
T
T
Site 17
T256
L
S
Q
P
I
R
K
T
T
K
E
D
I
R
K
Site 18
T257
S
Q
P
I
R
K
T
T
K
E
D
I
R
K
Q
Site 19
T266
E
D
I
R
K
Q
I
T
F
L
N
A
Q
I
D
Site 20
S280
D
R
H
C
L
K
M
S
K
V
A
E
S
L
I
Site 21
Y289
V
A
E
S
L
I
A
Y
T
E
Q
Y
V
E
Y
Site 22
T301
V
E
Y
D
P
L
I
T
P
A
E
P
S
N
P
Site 23
S306
L
I
T
P
A
E
P
S
N
P
W
I
S
D
D
Site 24
S311
E
P
S
N
P
W
I
S
D
D
V
A
L
W
D
Site 25
S322
A
L
W
D
I
E
M
S
K
E
P
S
Q
Q
R
Site 26
S326
I
E
M
S
K
E
P
S
Q
Q
R
V
K
R
W
Site 27
S336
R
V
K
R
W
G
F
S
F
D
E
I
L
K
D
Site 28
S356
Q
F
L
R
F
L
E
S
E
F
S
S
E
N
L
Site 29
S359
R
F
L
E
S
E
F
S
S
E
N
L
R
F
W
Site 30
S360
F
L
E
S
E
F
S
S
E
N
L
R
F
W
L
Site 31
S404
P
S
A
I
N
L
D
S
H
S
Y
E
I
T
S
Site 32
S406
A
I
N
L
D
S
H
S
Y
E
I
T
S
Q
N
Site 33
Y407
I
N
L
D
S
H
S
Y
E
I
T
S
Q
N
V
Site 34
S411
S
H
S
Y
E
I
T
S
Q
N
V
K
D
G
G
Site 35
T421
V
K
D
G
G
R
Y
T
F
E
D
A
Q
E
H
Site 36
S435
H
I
Y
K
L
M
K
S
D
S
Y
A
R
F
L
Site 37
S437
Y
K
L
M
K
S
D
S
Y
A
R
F
L
R
S
Site 38
Y438
K
L
M
K
S
D
S
Y
A
R
F
L
R
S
N
Site 39
Y447
R
F
L
R
S
N
A
Y
Q
D
L
L
L
A
K
Site 40
S459
L
A
K
K
K
G
K
S
L
A
G
K
R
L
T
Site 41
T466
S
L
A
G
K
R
L
T
G
L
M
Q
S
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation