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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLK2
Full Name:
Dual specificity protein kinase CLK2
Alias:
CDC-like kinase 2; Clk2; EC 2.7.12.1; Kinase CLK2
Type:
EC 2.7.12.1; Protein kinase, dual-specificity; CMGC group; CLK family
Mass (Da):
60090
Number AA:
499
UniProt ID:
P49760
International Prot ID:
IPI00028071
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
CLKSubtide - CLK2 protein kinase substrate peptide - Powder PE-01BGX80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BGX80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
P
H
P
R
R
Y
H
S
S
E
R
G
S
Site 2
S9
P
H
P
R
R
Y
H
S
S
E
R
G
S
R
G
Site 3
S10
H
P
R
R
Y
H
S
S
E
R
G
S
R
G
S
Site 4
S14
Y
H
S
S
E
R
G
S
R
G
S
Y
R
E
H
Site 5
S17
S
E
R
G
S
R
G
S
Y
R
E
H
Y
R
S
Site 6
Y18
E
R
G
S
R
G
S
Y
R
E
H
Y
R
S
R
Site 7
Y22
R
G
S
Y
R
E
H
Y
R
S
R
K
H
K
R
Site 8
S24
S
Y
R
E
H
Y
R
S
R
K
H
K
R
R
R
Site 9
S32
R
K
H
K
R
R
R
S
R
S
W
S
S
S
S
Site 10
S34
H
K
R
R
R
S
R
S
W
S
S
S
S
D
R
Site 11
S36
R
R
R
S
R
S
W
S
S
S
S
D
R
T
R
Site 12
S37
R
R
S
R
S
W
S
S
S
S
D
R
T
R
R
Site 13
S38
R
S
R
S
W
S
S
S
S
D
R
T
R
R
R
Site 14
S39
S
R
S
W
S
S
S
S
D
R
T
R
R
R
R
Site 15
T42
W
S
S
S
S
D
R
T
R
R
R
R
R
E
D
Site 16
S50
R
R
R
R
R
E
D
S
Y
H
V
R
S
R
S
Site 17
Y51
R
R
R
R
E
D
S
Y
H
V
R
S
R
S
S
Site 18
S55
E
D
S
Y
H
V
R
S
R
S
S
Y
D
D
R
Site 19
S57
S
Y
H
V
R
S
R
S
S
Y
D
D
R
S
S
Site 20
S58
Y
H
V
R
S
R
S
S
Y
D
D
R
S
S
D
Site 21
Y59
H
V
R
S
R
S
S
Y
D
D
R
S
S
D
R
Site 22
S63
R
S
S
Y
D
D
R
S
S
D
R
R
V
Y
D
Site 23
S64
S
S
Y
D
D
R
S
S
D
R
R
V
Y
D
R
Site 24
Y69
R
S
S
D
R
R
V
Y
D
R
R
Y
C
G
S
Site 25
Y73
R
R
V
Y
D
R
R
Y
C
G
S
Y
R
R
N
Site 26
S76
Y
D
R
R
Y
C
G
S
Y
R
R
N
D
Y
S
Site 27
Y77
D
R
R
Y
C
G
S
Y
R
R
N
D
Y
S
R
Site 28
Y82
G
S
Y
R
R
N
D
Y
S
R
D
R
G
D
A
Site 29
S83
S
Y
R
R
N
D
Y
S
R
D
R
G
D
A
Y
Site 30
Y90
S
R
D
R
G
D
A
Y
Y
D
T
D
Y
R
H
Site 31
Y91
R
D
R
G
D
A
Y
Y
D
T
D
Y
R
H
S
Site 32
Y95
D
A
Y
Y
D
T
D
Y
R
H
S
Y
E
Y
Q
Site 33
S98
Y
D
T
D
Y
R
H
S
Y
E
Y
Q
R
E
N
Site 34
Y99
D
T
D
Y
R
H
S
Y
E
Y
Q
R
E
N
S
Site 35
Y101
D
Y
R
H
S
Y
E
Y
Q
R
E
N
S
S
Y
Site 36
S106
Y
E
Y
Q
R
E
N
S
S
Y
R
S
Q
R
S
Site 37
S107
E
Y
Q
R
E
N
S
S
Y
R
S
Q
R
S
S
Site 38
Y108
Y
Q
R
E
N
S
S
Y
R
S
Q
R
S
S
R
Site 39
S110
R
E
N
S
S
Y
R
S
Q
R
S
S
R
R
K
Site 40
S113
S
S
Y
R
S
Q
R
S
S
R
R
K
H
R
R
Site 41
S114
S
Y
R
S
Q
R
S
S
R
R
K
H
R
R
R
Site 42
S125
H
R
R
R
R
R
R
S
R
T
F
S
R
S
S
Site 43
T127
R
R
R
R
R
S
R
T
F
S
R
S
S
S
Q
Site 44
S129
R
R
R
S
R
T
F
S
R
S
S
S
Q
H
S
Site 45
S131
R
S
R
T
F
S
R
S
S
S
Q
H
S
S
R
Site 46
S132
S
R
T
F
S
R
S
S
S
Q
H
S
S
R
R
Site 47
S133
R
T
F
S
R
S
S
S
Q
H
S
S
R
R
A
Site 48
S136
S
R
S
S
S
Q
H
S
S
R
R
A
K
S
V
Site 49
S137
R
S
S
S
Q
H
S
S
R
R
A
K
S
V
E
Site 50
S142
H
S
S
R
R
A
K
S
V
E
D
D
A
E
G
Site 51
Y153
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
Site 52
Y163
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
Site 53
S167
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
Site 54
T168
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
Site 55
Y259
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
Site 56
Y262
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
Site 57
Y303
I
L
F
V
N
S
D
Y
E
L
T
Y
N
L
E
Site 58
S317
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
Site 59
S320
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
Site 60
T321
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
Site 61
S330
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
Site 62
T332
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
Site 63
T340
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
Site 64
S343
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
Site 65
T344
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
Site 66
Y347
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
Site 67
T383
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
Site 68
S402
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
Site 69
T408
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
Site 70
Y413
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
Site 71
T425
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
Site 72
Y430
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
Site 73
Y441
N
C
K
P
L
R
R
Y
L
T
S
E
A
E
E
Site 74
T443
K
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Site 75
S444
P
L
R
R
Y
L
T
S
E
A
E
E
H
H
Q
Site 76
Y462
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
Site 77
T469
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
Site 78
S493
P
P
N
K
L
W
D
S
S
R
D
I
S
R
_
Site 79
S494
P
N
K
L
W
D
S
S
R
D
I
S
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation