KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EIF2B2
Full Name:
Translation initiation factor eIF-2B subunit beta
Alias:
E2BB; EI2BB; EIF-2B GDP-GTP exchange factor; EIF-2B GDP-GTP exchange factor subunit beta; EIF2BB; S20I15; S20III15
Type:
Protein synthesis initiation protein
Mass (Da):
38990
Number AA:
351
UniProt ID:
P49770
International Prot ID:
IPI00028083
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005851
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051716
GO:0042552
GO:0014003
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
A
K
G
S
E
L
S
E
R
I
E
S
F
V
Site 2
S17
E
L
S
E
R
I
E
S
F
V
E
T
L
K
R
Site 3
T21
R
I
E
S
F
V
E
T
L
K
R
G
G
G
P
Site 4
S30
K
R
G
G
G
P
R
S
S
E
E
M
A
R
E
Site 5
S31
R
G
G
G
P
R
S
S
E
E
M
A
R
E
T
Site 6
T38
S
E
E
M
A
R
E
T
L
G
L
L
R
Q
I
Site 7
T47
G
L
L
R
Q
I
I
T
D
H
R
W
S
N
A
Site 8
T69
R
R
E
G
R
R
M
T
A
A
Q
P
S
E
T
Site 9
Y93
L
K
I
I
R
E
E
Y
G
R
L
H
G
R
S
Site 10
S100
Y
G
R
L
H
G
R
S
D
E
S
D
Q
Q
E
Site 11
S103
L
H
G
R
S
D
E
S
D
Q
Q
E
S
L
H
Site 12
S108
D
E
S
D
Q
Q
E
S
L
H
K
L
L
T
S
Site 13
T114
E
S
L
H
K
L
L
T
S
G
G
L
N
E
D
Site 14
S123
G
G
L
N
E
D
F
S
F
H
Y
A
Q
L
Q
Site 15
Y126
N
E
D
F
S
F
H
Y
A
Q
L
Q
S
N
I
Site 16
T236
V
N
K
V
I
I
G
T
K
T
I
L
A
N
G
Site 17
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
A
L
Site 18
S275
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
E
Site 19
S284
Q
F
P
N
E
E
D
S
F
H
K
F
V
A
P
Site 20
T298
P
E
E
V
L
P
F
T
E
G
D
I
L
E
K
Site 21
Y315
V
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Site 22
S334
N
I
G
G
N
A
P
S
Y
I
Y
R
L
M
S
Site 23
Y335
I
G
G
N
A
P
S
Y
I
Y
R
L
M
S
E
Site 24
Y337
G
N
A
P
S
Y
I
Y
R
L
M
S
E
L
Y
Site 25
S341
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
D
D
Site 26
Y344
Y
R
L
M
S
E
L
Y
H
P
D
D
H
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation