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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RGS3
Full Name:
Regulator of G-protein signaling 3
Alias:
C2PA; FLJ20370; PDZ-RGS3; RGP3
Type:
GTPase activating protein, RGS
Mass (Da):
132336
Number AA:
1198
UniProt ID:
P49796
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0000188
GO:0009968
GO:0008277
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
W
E
V
E
M
G
R
S
Q
G
Q
E
I
E
T
Site 2
S28
E
T
I
L
A
N
R
S
H
S
D
S
T
P
L
Site 3
S30
I
L
A
N
R
S
H
S
D
S
T
P
L
P
N
Site 4
S32
A
N
R
S
H
S
D
S
T
P
L
P
N
F
L
Site 5
T33
N
R
S
H
S
D
S
T
P
L
P
N
F
L
S
Site 6
S40
T
P
L
P
N
F
L
S
G
S
H
R
P
E
C
Site 7
S42
L
P
N
F
L
S
G
S
H
R
P
E
C
C
T
Site 8
T49
S
H
R
P
E
C
C
T
C
R
L
L
T
A
S
Site 9
S56
T
C
R
L
L
T
A
S
G
A
Q
D
S
L
P
Site 10
S61
T
A
S
G
A
Q
D
S
L
P
F
G
R
R
L
Site 11
Y69
L
P
F
G
R
R
L
Y
S
G
P
W
R
S
C
Site 12
S70
P
F
G
R
R
L
Y
S
G
P
W
R
S
C
E
Site 13
S109
P
G
W
M
E
W
L
S
P
D
I
A
L
P
R
Site 14
T121
L
P
R
R
D
E
W
T
Q
T
S
P
A
R
K
Site 15
T123
R
R
D
E
W
T
Q
T
S
P
A
R
K
R
I
Site 16
S124
R
D
E
W
T
Q
T
S
P
A
R
K
R
I
T
Site 17
T131
S
P
A
R
K
R
I
T
H
A
K
V
Q
G
A
Site 18
S144
G
A
G
Q
L
R
L
S
I
D
A
Q
D
R
V
Site 19
T169
L
I
S
K
Q
P
G
T
C
D
P
Y
V
K
I
Site 20
Y173
Q
P
G
T
C
D
P
Y
V
K
I
S
L
I
P
Site 21
S177
C
D
P
Y
V
K
I
S
L
I
P
E
D
S
R
Site 22
S183
I
S
L
I
P
E
D
S
R
L
R
H
Q
K
T
Site 23
T190
S
R
L
R
H
Q
K
T
Q
T
V
P
D
C
R
Site 24
T192
L
R
H
Q
K
T
Q
T
V
P
D
C
R
D
P
Site 25
T221
D
Q
K
R
L
L
V
T
V
W
N
R
A
S
Q
Site 26
S227
V
T
V
W
N
R
A
S
Q
S
R
Q
S
G
L
Site 27
S229
V
W
N
R
A
S
Q
S
R
Q
S
G
L
I
G
Site 28
S232
R
A
S
Q
S
R
Q
S
G
L
I
G
C
M
S
Site 29
S244
C
M
S
F
G
V
K
S
L
L
T
P
D
K
E
Site 30
T247
F
G
V
K
S
L
L
T
P
D
K
E
I
S
G
Site 31
S253
L
T
P
D
K
E
I
S
G
W
Y
Y
L
L
G
Site 32
Y256
D
K
E
I
S
G
W
Y
Y
L
L
G
E
H
L
Site 33
Y257
K
E
I
S
G
W
Y
Y
L
L
G
E
H
L
G
Site 34
T292
R
M
P
G
G
G
D
T
E
N
G
K
K
L
K
Site 35
T301
N
G
K
K
L
K
I
T
I
P
R
G
K
D
G
Site 36
T340
A
G
L
Q
Q
L
D
T
V
L
Q
L
N
E
R
Site 37
S392
G
G
V
L
R
R
A
S
C
K
S
T
H
D
L
Site 38
S395
L
R
R
A
S
C
K
S
T
H
D
L
Q
S
P
Site 39
T396
R
R
A
S
C
K
S
T
H
D
L
Q
S
P
P
Site 40
S401
K
S
T
H
D
L
Q
S
P
P
N
K
R
E
K
Site 41
T411
N
K
R
E
K
N
C
T
H
G
V
Q
A
R
P
Site 42
S423
A
R
P
E
Q
R
H
S
C
H
L
V
C
D
S
Site 43
Y442
L
L
G
G
W
E
R
Y
T
E
V
A
K
R
G
Site 44
T443
L
G
G
W
E
R
Y
T
E
V
A
K
R
G
G
Site 45
T453
A
K
R
G
G
Q
H
T
L
P
A
L
S
R
A
Site 46
S458
Q
H
T
L
P
A
L
S
R
A
T
A
P
T
D
Site 47
T461
L
P
A
L
S
R
A
T
A
P
T
D
P
N
Y
Site 48
Y485
S
Q
L
L
R
P
V
Y
Q
E
D
T
I
P
E
Site 49
T489
R
P
V
Y
Q
E
D
T
I
P
E
E
S
G
S
Site 50
S494
E
D
T
I
P
E
E
S
G
S
P
S
K
G
K
Site 51
S496
T
I
P
E
E
S
G
S
P
S
K
G
K
S
Y
Site 52
S498
P
E
E
S
G
S
P
S
K
G
K
S
Y
T
G
Site 53
S502
G
S
P
S
K
G
K
S
Y
T
G
L
G
K
K
Site 54
Y503
S
P
S
K
G
K
S
Y
T
G
L
G
K
K
S
Site 55
S510
Y
T
G
L
G
K
K
S
R
L
M
K
T
V
Q
Site 56
T515
K
K
S
R
L
M
K
T
V
Q
T
M
K
G
H
Site 57
Y525
T
M
K
G
H
G
N
Y
Q
N
C
P
V
V
R
Site 58
T536
P
V
V
R
P
H
A
T
H
S
S
Y
G
T
Y
Site 59
S538
V
R
P
H
A
T
H
S
S
Y
G
T
Y
V
T
Site 60
S539
R
P
H
A
T
H
S
S
Y
G
T
Y
V
T
L
Site 61
Y543
T
H
S
S
Y
G
T
Y
V
T
L
A
P
K
V
Site 62
T545
S
S
Y
G
T
Y
V
T
L
A
P
K
V
L
V
Site 63
Y578
L
S
E
E
L
L
L
Y
E
G
R
N
K
A
A
Site 64
Y615
D
V
L
R
N
P
L
Y
L
Q
S
V
K
L
Q
Site 65
S625
S
V
K
L
Q
E
G
S
S
E
D
L
K
F
C
Site 66
S626
V
K
L
Q
E
G
S
S
E
D
L
K
F
C
V
Site 67
T645
E
K
A
E
C
L
F
T
L
E
A
H
S
Q
E
Site 68
S674
K
Q
Q
Q
L
A
A
S
P
P
D
S
K
M
F
Site 69
S678
L
A
A
S
P
P
D
S
K
M
F
E
T
E
A
Site 70
S704
K
G
P
G
A
E
D
S
P
P
S
K
E
P
S
Site 71
S707
G
A
E
D
S
P
P
S
K
E
P
S
P
G
Q
Site 72
S711
S
P
P
S
K
E
P
S
P
G
Q
E
L
P
P
Site 73
S728
D
L
P
P
N
K
D
S
P
S
G
Q
E
P
A
Site 74
S730
P
P
N
K
D
S
P
S
G
Q
E
P
A
P
S
Site 75
S737
S
G
Q
E
P
A
P
S
Q
E
P
L
S
S
K
Site 76
S742
A
P
S
Q
E
P
L
S
S
K
D
S
A
T
S
Site 77
S743
P
S
Q
E
P
L
S
S
K
D
S
A
T
S
E
Site 78
S746
E
P
L
S
S
K
D
S
A
T
S
E
G
S
P
Site 79
T748
L
S
S
K
D
S
A
T
S
E
G
S
P
P
G
Site 80
S749
S
S
K
D
S
A
T
S
E
G
S
P
P
G
P
Site 81
S752
D
S
A
T
S
E
G
S
P
P
G
P
D
A
P
Site 82
S761
P
G
P
D
A
P
P
S
K
D
V
P
P
C
Q
Site 83
S777
P
P
P
A
Q
D
L
S
P
C
Q
D
L
P
A
Site 84
S806
D
L
P
A
I
Q
E
S
P
T
R
D
L
P
P
Site 85
S820
P
C
Q
D
L
P
P
S
Q
V
S
L
P
A
K
Site 86
S823
D
L
P
P
S
Q
V
S
L
P
A
K
A
L
T
Site 87
T830
S
L
P
A
K
A
L
T
E
D
T
M
S
S
G
Site 88
T833
A
K
A
L
T
E
D
T
M
S
S
G
D
L
L
Site 89
T843
S
G
D
L
L
A
A
T
G
D
P
P
A
A
P
Site 90
S863
I
P
E
V
R
L
D
S
T
Y
S
Q
K
A
G
Site 91
T864
P
E
V
R
L
D
S
T
Y
S
Q
K
A
G
A
Site 92
Y865
E
V
R
L
D
S
T
Y
S
Q
K
A
G
A
E
Site 93
S866
V
R
L
D
S
T
Y
S
Q
K
A
G
A
E
Q
Site 94
S876
A
G
A
E
Q
G
C
S
G
D
E
E
D
A
E
Site 95
T902
E
E
D
E
D
E
D
T
S
D
D
N
Y
G
E
Site 96
S903
E
D
E
D
E
D
T
S
D
D
N
Y
G
E
R
Site 97
Y907
E
D
T
S
D
D
N
Y
G
E
R
S
E
A
K
Site 98
S911
D
D
N
Y
G
E
R
S
E
A
K
R
S
S
M
Site 99
S916
E
R
S
E
A
K
R
S
S
M
I
E
T
G
Q
Site 100
S917
R
S
E
A
K
R
S
S
M
I
E
T
G
Q
G
Site 101
T921
K
R
S
S
M
I
E
T
G
Q
G
A
E
G
G
Site 102
S930
Q
G
A
E
G
G
L
S
L
R
V
Q
N
S
L
Site 103
S936
L
S
L
R
V
Q
N
S
L
R
R
R
T
H
S
Site 104
T941
Q
N
S
L
R
R
R
T
H
S
E
G
S
L
L
Site 105
S943
S
L
R
R
R
T
H
S
E
G
S
L
L
Q
E
Site 106
S946
R
R
T
H
S
E
G
S
L
L
Q
E
P
R
G
Site 107
S958
P
R
G
P
C
F
A
S
D
T
T
L
H
C
S
Site 108
T960
G
P
C
F
A
S
D
T
T
L
H
C
S
D
G
Site 109
T961
P
C
F
A
S
D
T
T
L
H
C
S
D
G
E
Site 110
S965
S
D
T
T
L
H
C
S
D
G
E
G
A
A
S
Site 111
S972
S
D
G
E
G
A
A
S
T
W
G
M
P
S
P
Site 112
S978
A
S
T
W
G
M
P
S
P
S
T
L
K
K
E
Site 113
S980
T
W
G
M
P
S
P
S
T
L
K
K
E
L
G
Site 114
T981
W
G
M
P
S
P
S
T
L
K
K
E
L
G
R
Site 115
S992
E
L
G
R
N
G
G
S
M
H
H
L
S
L
F
Site 116
S997
G
G
S
M
H
H
L
S
L
F
F
T
G
H
R
Site 117
T1001
H
H
L
S
L
F
F
T
G
H
R
K
M
S
G
Site 118
S1007
F
T
G
H
R
K
M
S
G
A
D
T
V
G
D
Site 119
T1011
R
K
M
S
G
A
D
T
V
G
D
D
D
E
A
Site 120
S1019
V
G
D
D
D
E
A
S
R
K
R
K
S
K
N
Site 121
S1024
E
A
S
R
K
R
K
S
K
N
L
A
K
D
M
Site 122
S1044
I
F
R
R
R
N
E
S
P
G
A
P
P
A
G
Site 123
S1059
K
A
D
K
M
M
K
S
F
K
P
T
S
E
E
Site 124
T1063
M
M
K
S
F
K
P
T
S
E
E
A
L
K
W
Site 125
S1064
M
K
S
F
K
P
T
S
E
E
A
L
K
W
G
Site 126
S1073
E
A
L
K
W
G
E
S
L
E
K
L
L
V
H
Site 127
S1096
A
F
L
R
T
E
F
S
E
E
N
L
E
F
W
Site 128
S1114
E
D
F
K
K
V
K
S
Q
S
K
M
A
S
K
Site 129
S1116
F
K
K
V
K
S
Q
S
K
M
A
S
K
A
K
Site 130
S1120
K
S
Q
S
K
M
A
S
K
A
K
K
I
F
A
Site 131
S1142
C
K
E
V
N
L
D
S
Y
T
R
E
H
T
K
Site 132
Y1143
K
E
V
N
L
D
S
Y
T
R
E
H
T
K
D
Site 133
T1148
D
S
Y
T
R
E
H
T
K
D
N
L
Q
S
V
Site 134
S1175
F
G
L
M
E
K
D
S
Y
P
R
F
L
R
S
Site 135
Y1176
G
L
M
E
K
D
S
Y
P
R
F
L
R
S
D
Site 136
S1182
S
Y
P
R
F
L
R
S
D
L
Y
L
D
L
I
Site 137
Y1185
R
F
L
R
S
D
L
Y
L
D
L
I
N
Q
K
Site 138
S1195
L
I
N
Q
K
K
M
S
P
P
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation