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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSEN2
Full Name:
Presenilin-2
Alias:
AD3L; AD3LP; AD4; AD4H; AD5; ALG3; ALG-3; Alzheimer disease 4 homolog; E5-1; Presenilin 2; Presenilin 2 (Alzheimer disease 4); PS2; PS-2; PSN2; PSNL2; STM2; STM-2
Type:
Protease; EC 3.4.23.-; Cell surface
Mass (Da):
50140
Number AA:
448
UniProt ID:
P49810
International Prot ID:
IPI00184584
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007220
GO:0042987
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
L
T
F
M
A
S
D
S
E
E
E
V
C
Site 2
S9
L
T
F
M
A
S
D
S
E
E
E
V
C
D
E
Site 3
T18
E
E
V
C
D
E
R
T
S
L
M
S
A
E
S
Site 4
S19
E
V
C
D
E
R
T
S
L
M
S
A
E
S
P
Site 5
S22
D
E
R
T
S
L
M
S
A
E
S
P
T
P
R
Site 6
S25
T
S
L
M
S
A
E
S
P
T
P
R
S
C
Q
Site 7
T27
L
M
S
A
E
S
P
T
P
R
S
C
Q
E
G
Site 8
S30
A
E
S
P
T
P
R
S
C
Q
E
G
R
Q
G
Site 9
S49
E
N
T
A
Q
W
R
S
Q
E
N
E
E
D
G
Site 10
Y63
G
E
E
D
P
D
R
Y
V
C
S
G
V
P
G
Site 11
S66
D
P
D
R
Y
V
C
S
G
V
P
G
R
P
P
Site 12
T80
P
G
L
E
E
E
L
T
L
K
Y
G
A
K
H
Site 13
Y83
E
E
E
L
T
L
K
Y
G
A
K
H
V
I
M
Site 14
Y112
T
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
Site 15
T113
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Site 16
T122
K
N
G
Q
L
I
Y
T
P
F
T
E
D
T
P
Site 17
T125
Q
L
I
Y
T
P
F
T
E
D
T
P
S
V
G
Site 18
T128
Y
T
P
F
T
E
D
T
P
S
V
G
Q
R
L
Site 19
S130
P
F
T
E
D
T
P
S
V
G
Q
R
L
L
N
Site 20
T194
Y
L
G
E
V
L
K
T
Y
N
V
A
M
D
Y
Site 21
Y195
L
G
E
V
L
K
T
Y
N
V
A
M
D
Y
P
Site 22
T280
P
L
R
M
L
V
E
T
A
Q
E
R
N
E
P
Site 23
Y294
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
Site 24
S311
M
A
K
L
D
P
S
S
Q
G
A
L
Q
L
P
Site 25
Y319
Q
G
A
L
Q
L
P
Y
D
P
E
M
E
E
D
Site 26
S327
D
P
E
M
E
E
D
S
Y
D
S
F
G
E
P
Site 27
Y328
P
E
M
E
E
D
S
Y
D
S
F
G
E
P
S
Site 28
S330
M
E
E
D
S
Y
D
S
F
G
E
P
S
Y
P
Site 29
S335
Y
D
S
F
G
E
P
S
Y
P
E
V
F
E
P
Site 30
Y336
D
S
F
G
E
P
S
Y
P
E
V
F
E
P
P
Site 31
T345
E
V
F
E
P
P
L
T
G
Y
P
G
E
E
L
Site 32
Y347
F
E
P
P
L
T
G
Y
P
G
E
E
L
E
E
Site 33
S382
G
K
A
A
A
T
G
S
G
D
W
N
T
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation