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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NT5C2
Full Name:
Cytosolic purine 5'-nucleotidase
Alias:
5NTC; 5'-nucleotidase (purine), cytosolic type B; 5'-nucleotidase, cytosolic II; CN-II; EC 3.1.3.5; GMP; IMP-specific 5'-NT; NT5B; NT5CP; PNT5
Type:
Nucleotide Metabolism - purine; EC 3.1.3.5; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - pyrimidine; Hydrolase
Mass (Da):
64970
Number AA:
561
UniProt ID:
P49902
International Prot ID:
IPI00029054
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008253
GO:0000287
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0009117
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y27
D
K
H
A
L
K
K
Y
R
R
E
A
Y
H
R
Site 2
Y32
K
K
Y
R
R
E
A
Y
H
R
V
F
V
N
R
Site 3
T56
F
G
F
D
M
D
Y
T
L
A
V
Y
K
S
P
Site 4
Y60
M
D
Y
T
L
A
V
Y
K
S
P
E
Y
E
S
Site 5
S62
Y
T
L
A
V
Y
K
S
P
E
Y
E
S
L
G
Site 6
Y65
A
V
Y
K
S
P
E
Y
E
S
L
G
F
E
L
Site 7
S67
Y
K
S
P
E
Y
E
S
L
G
F
E
L
T
V
Site 8
S88
G
Y
P
Q
E
L
L
S
F
A
Y
D
S
T
F
Site 9
Y91
Q
E
L
L
S
F
A
Y
D
S
T
F
P
T
R
Site 10
T133
N
F
I
R
G
P
E
T
R
E
Q
Y
P
N
K
Site 11
Y137
G
P
E
T
R
E
Q
Y
P
N
K
F
I
Q
R
Site 12
T147
K
F
I
Q
R
D
D
T
E
R
F
Y
I
L
N
Site 13
Y151
R
D
D
T
E
R
F
Y
I
L
N
T
L
F
N
Site 14
T155
E
R
F
Y
I
L
N
T
L
F
N
L
P
E
T
Site 15
Y178
F
F
T
N
C
P
R
Y
T
S
C
E
T
G
F
Site 16
Y194
D
G
D
L
F
M
S
Y
R
S
M
F
Q
D
V
Site 17
T218
K
G
S
L
K
E
K
T
V
E
N
L
E
K
Y
Site 18
Y225
T
V
E
N
L
E
K
Y
V
V
K
D
G
K
L
Site 19
S237
G
K
L
P
L
L
L
S
R
M
K
E
V
G
K
Site 20
Y253
F
L
A
T
N
S
D
Y
K
Y
T
D
K
I
M
Site 21
Y255
A
T
N
S
D
Y
K
Y
T
D
K
I
M
T
Y
Site 22
Y262
Y
T
D
K
I
M
T
Y
L
F
D
F
P
H
G
Site 23
S274
P
H
G
P
K
P
G
S
S
H
R
P
W
Q
S
Site 24
S275
H
G
P
K
P
G
S
S
H
R
P
W
Q
S
Y
Site 25
S281
S
S
H
R
P
W
Q
S
Y
F
D
L
I
L
V
Site 26
Y282
S
H
R
P
W
Q
S
Y
F
D
L
I
L
V
D
Site 27
T307
T
V
L
R
Q
V
D
T
K
T
G
K
L
K
I
Site 28
T309
L
R
Q
V
D
T
K
T
G
K
L
K
I
G
T
Site 29
Y317
G
K
L
K
I
G
T
Y
T
G
P
L
Q
H
G
Site 30
Y327
P
L
Q
H
G
I
V
Y
S
G
G
S
S
D
T
Site 31
S328
L
Q
H
G
I
V
Y
S
G
G
S
S
D
T
I
Site 32
T368
K
K
R
Q
G
W
R
T
F
L
V
I
P
E
L
Site 33
T383
A
Q
E
L
H
V
W
T
D
K
S
S
L
F
E
Site 34
S386
L
H
V
W
T
D
K
S
S
L
F
E
E
L
Q
Site 35
S387
H
V
W
T
D
K
S
S
L
F
E
E
L
Q
S
Site 36
Y403
D
I
F
L
A
E
L
Y
K
H
L
D
S
S
S
Site 37
S408
E
L
Y
K
H
L
D
S
S
S
N
E
R
P
D
Site 38
S410
Y
K
H
L
D
S
S
S
N
E
R
P
D
I
S
Site 39
S418
N
E
R
P
D
I
S
S
I
Q
R
R
I
K
K
Site 40
T427
Q
R
R
I
K
K
V
T
H
D
M
D
M
C
Y
Site 41
S439
M
C
Y
G
M
M
G
S
L
F
R
S
G
S
R
Site 42
S443
M
M
G
S
L
F
R
S
G
S
R
Q
T
L
F
Site 43
S445
G
S
L
F
R
S
G
S
R
Q
T
L
F
A
S
Site 44
T448
F
R
S
G
S
R
Q
T
L
F
A
S
Q
V
M
Site 45
S452
S
R
Q
T
L
F
A
S
Q
V
M
R
Y
A
D
Site 46
S502
V
D
I
N
E
M
E
S
P
L
A
T
R
N
R
Site 47
T506
E
M
E
S
P
L
A
T
R
N
R
T
S
V
D
Site 48
T510
P
L
A
T
R
N
R
T
S
V
D
F
K
D
T
Site 49
S511
L
A
T
R
N
R
T
S
V
D
F
K
D
T
D
Site 50
T517
T
S
V
D
F
K
D
T
D
Y
K
R
H
Q
L
Site 51
Y519
V
D
F
K
D
T
D
Y
K
R
H
Q
L
T
R
Site 52
T525
D
Y
K
R
H
Q
L
T
R
S
I
S
E
I
K
Site 53
S527
K
R
H
Q
L
T
R
S
I
S
E
I
K
P
P
Site 54
S529
H
Q
L
T
R
S
I
S
E
I
K
P
P
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation