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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GMPS
Full Name:
GMP synthase [glutamine-hydrolyzing]
Alias:
Glutamine amidotransferase; GMP synthetase; GUAA; Guanine monphosphate synthetase
Type:
EC 6.3.5.2; Ligase; Nucleotide Metabolism - purine; Xenobiotic Metabolism - drug metabolism - other enzymes
Mass (Da):
76715
Number AA:
693
UniProt ID:
P49915
International Prot ID:
IPI00029079
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003922
GO:0003921
PhosphoSite+
KinaseNET
Biological Process:
GO:0006177
GO:0006541
GO:0009113
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
L
C
N
G
D
S
K
L
E
N
A
G
G
Site 2
Y24
L
K
D
G
H
H
H
Y
E
G
A
V
V
I
L
Site 3
S80
I
I
S
G
G
P
N
S
V
Y
A
E
D
A
P
Site 4
Y82
S
G
G
P
N
S
V
Y
A
E
D
A
P
W
F
Site 5
S122
G
G
T
V
H
K
K
S
V
R
E
D
G
V
F
Site 6
S132
E
D
G
V
F
N
I
S
V
D
N
T
C
S
L
Site 7
S138
I
S
V
D
N
T
C
S
L
F
R
G
L
Q
K
Site 8
T152
K
E
E
V
V
L
L
T
H
G
D
S
V
D
K
Site 9
Y185
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
Site 10
T216
D
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
Site 11
T218
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
Site 12
T253
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
Site 13
S280
G
F
M
R
K
R
E
S
Q
S
V
E
E
A
L
Site 14
S282
M
R
K
R
E
S
Q
S
V
E
E
A
L
K
K
Site 15
S302
K
V
I
N
A
A
H
S
F
Y
N
G
T
T
T
Site 16
T309
S
F
Y
N
G
T
T
T
L
P
I
S
D
E
D
Site 17
S313
G
T
T
T
L
P
I
S
D
E
D
R
T
P
R
Site 18
T318
P
I
S
D
E
D
R
T
P
R
K
R
I
S
K
Site 19
S324
R
T
P
R
K
R
I
S
K
T
L
N
M
T
T
Site 20
T326
P
R
K
R
I
S
K
T
L
N
M
T
T
S
P
Site 21
T330
I
S
K
T
L
N
M
T
T
S
P
E
E
K
R
Site 22
T331
S
K
T
L
N
M
T
T
S
P
E
E
K
R
K
Site 23
S332
K
T
L
N
M
T
T
S
P
E
E
K
R
K
I
Site 24
T343
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
Site 25
T390
G
K
A
E
L
I
K
T
H
H
N
D
T
E
L
Site 26
S434
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
Site 27
Y454
V
I
C
A
E
E
P
Y
I
C
K
D
F
P
E
Site 28
S473
L
K
I
V
A
D
F
S
A
S
V
K
K
P
H
Site 29
T481
A
S
V
K
K
P
H
T
L
L
Q
R
V
K
A
Site 30
T490
L
Q
R
V
K
A
C
T
T
E
E
D
Q
E
K
Site 31
Y526
V
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
S
Site 32
S527
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
S
S
Site 33
Y528
G
D
C
R
S
Y
S
Y
V
C
G
I
S
S
K
Site 34
S534
S
Y
V
C
G
I
S
S
K
D
E
P
D
W
E
Site 35
S542
K
D
E
P
D
W
E
S
L
I
F
L
A
R
L
Site 36
T573
P
P
V
K
E
P
P
T
D
V
T
P
T
F
L
Site 37
T576
K
E
P
P
T
D
V
T
P
T
F
L
T
T
G
Site 38
S602
A
H
N
I
L
R
E
S
G
Y
A
G
K
I
S
Site 39
Y604
N
I
L
R
E
S
G
Y
A
G
K
I
S
Q
M
Site 40
T616
S
Q
M
P
V
I
L
T
P
L
H
F
D
R
D
Site 41
S630
D
P
L
Q
K
Q
P
S
C
Q
R
S
V
V
I
Site 42
S634
K
Q
P
S
C
Q
R
S
V
V
I
R
T
F
I
Site 43
Y680
P
G
I
S
R
I
M
Y
D
L
T
S
K
P
P
Site 44
T683
S
R
I
M
Y
D
L
T
S
K
P
P
G
T
T
Site 45
S684
R
I
M
Y
D
L
T
S
K
P
P
G
T
T
E
Site 46
T689
L
T
S
K
P
P
G
T
T
E
W
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation