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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LIG3
Full Name:
DNA ligase 3
Alias:
DNA ligase III; DNL3; LIG2; Ligase III, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP]; Polydeoxyribonucleotide synthase [ATP] 3
Type:
EC 6.5.1.1; Ligase
Mass (Da):
112907
Number AA:
1009
UniProt ID:
P49916
International Prot ID:
IPI00000156
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003910
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006260
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
F
K
I
F
F
P
Q
T
L
R
A
L
S
R
K
Site 2
S17
P
Q
T
L
R
A
L
S
R
K
E
L
C
L
F
Site 3
S36
W
R
D
V
R
Q
F
S
Q
W
S
E
T
D
L
Site 4
S39
V
R
Q
F
S
Q
W
S
E
T
D
L
L
H
G
Site 5
S58
L
R
R
K
P
V
L
S
F
Q
G
S
H
L
R
Site 6
S62
P
V
L
S
F
Q
G
S
H
L
R
S
R
A
T
Site 7
S66
F
Q
G
S
H
L
R
S
R
A
T
Y
L
V
F
Site 8
Y97
E
Q
R
F
C
V
D
Y
A
K
R
G
T
A
G
Site 9
T102
V
D
Y
A
K
R
G
T
A
G
C
K
K
C
K
Site 10
S128
K
V
V
P
N
P
F
S
E
S
G
G
D
M
K
Site 11
T153
K
L
E
R
A
R
A
T
T
K
K
I
E
D
L
Site 12
T154
L
E
R
A
R
A
T
T
K
K
I
E
D
L
T
Site 13
T161
T
K
K
I
E
D
L
T
E
L
E
G
W
E
E
Site 14
S186
Q
H
I
A
D
L
S
S
K
A
A
G
T
P
K
Site 15
T191
L
S
S
K
A
A
G
T
P
K
K
K
A
V
V
Site 16
T204
V
V
Q
A
K
L
T
T
T
G
Q
V
T
S
P
Site 17
T209
L
T
T
T
G
Q
V
T
S
P
V
K
G
A
S
Site 18
S210
T
T
T
G
Q
V
T
S
P
V
K
G
A
S
F
Site 19
S216
T
S
P
V
K
G
A
S
F
V
T
S
T
N
P
Site 20
S220
K
G
A
S
F
V
T
S
T
N
P
R
K
F
S
Site 21
T221
G
A
S
F
V
T
S
T
N
P
R
K
F
S
G
Site 22
S227
S
T
N
P
R
K
F
S
G
F
S
A
K
P
N
Site 23
S230
P
R
K
F
S
G
F
S
A
K
P
N
N
S
G
Site 24
S236
F
S
A
K
P
N
N
S
G
E
A
P
S
S
P
Site 25
S241
N
N
S
G
E
A
P
S
S
P
T
P
K
R
S
Site 26
S242
N
S
G
E
A
P
S
S
P
T
P
K
R
S
L
Site 27
T244
G
E
A
P
S
S
P
T
P
K
R
S
L
S
S
Site 28
S248
S
S
P
T
P
K
R
S
L
S
S
S
K
C
D
Site 29
S250
P
T
P
K
R
S
L
S
S
S
K
C
D
P
R
Site 30
S252
P
K
R
S
L
S
S
S
K
C
D
P
R
H
K
Site 31
S278
A
M
V
A
D
N
P
S
Y
N
T
K
T
Q
I
Site 32
Y279
M
V
A
D
N
P
S
Y
N
T
K
T
Q
I
I
Site 33
S294
Q
D
F
L
R
K
G
S
A
G
D
G
F
H
G
Site 34
Y319
P
G
V
I
K
T
V
Y
N
L
N
D
K
Q
I
Site 35
S351
D
L
E
Q
G
D
V
S
E
T
I
R
V
F
F
Site 36
T353
E
Q
G
D
V
S
E
T
I
R
V
F
F
E
Q
Site 37
S361
I
R
V
F
F
E
Q
S
K
S
F
P
P
A
A
Site 38
S363
V
F
F
E
Q
S
K
S
F
P
P
A
A
K
S
Site 39
S385
D
E
F
L
L
R
L
S
K
L
T
K
E
D
E
Site 40
T388
L
L
R
L
S
K
L
T
K
E
D
E
Q
Q
Q
Site 41
S402
Q
A
L
Q
D
I
A
S
R
C
T
A
N
D
L
Site 42
T405
Q
D
I
A
S
R
C
T
A
N
D
L
K
C
I
Site 43
Y438
D
A
L
D
P
N
A
Y
E
A
F
K
A
S
R
Site 44
S472
P
G
Q
R
R
A
L
S
V
Q
A
S
L
M
T
Site 45
T479
S
V
Q
A
S
L
M
T
P
V
Q
P
M
L
A
Site 46
S491
M
L
A
E
A
C
K
S
V
E
Y
A
M
K
K
Site 47
Y509
G
M
F
S
E
I
K
Y
D
G
E
R
V
Q
V
Site 48
S524
H
K
N
G
D
H
F
S
Y
F
S
R
S
L
K
Site 49
Y525
K
N
G
D
H
F
S
Y
F
S
R
S
L
K
P
Site 50
S529
H
F
S
Y
F
S
R
S
L
K
P
V
L
P
H
Site 51
Y544
K
V
A
H
F
K
D
Y
I
P
Q
A
F
P
G
Site 52
T637
F
S
E
M
K
R
V
T
K
A
L
D
L
A
D
Site 53
T647
L
D
L
A
D
M
I
T
R
V
I
Q
E
G
L
Site 54
Y666
L
K
D
V
K
G
T
Y
E
P
G
K
R
H
W
Site 55
Y680
W
L
K
V
K
K
D
Y
L
N
E
G
A
M
A
Site 56
S703
G
A
F
Y
G
Q
G
S
K
G
G
M
M
S
I
Site 57
Y716
S
I
F
L
M
G
C
Y
D
P
G
S
Q
K
W
Site 58
T725
P
G
S
Q
K
W
C
T
V
T
K
C
A
G
G
Site 59
T737
A
G
G
H
D
D
A
T
L
A
R
L
Q
N
E
Site 60
S751
E
L
D
M
V
K
I
S
K
D
P
S
K
I
P
Site 61
S755
V
K
I
S
K
D
P
S
K
I
P
S
W
L
K
Site 62
S759
K
D
P
S
K
I
P
S
W
L
K
V
N
K
I
Site 63
Y767
W
L
K
V
N
K
I
Y
Y
P
D
F
I
V
P
Site 64
Y768
L
K
V
N
K
I
Y
Y
P
D
F
I
V
P
D
Site 65
S792
T
G
A
E
F
S
K
S
E
A
H
T
A
D
G
Site 66
T796
F
S
K
S
E
A
H
T
A
D
G
I
S
I
R
Site 67
T808
S
I
R
F
P
R
C
T
R
I
R
D
D
K
D
Site 68
S818
R
D
D
K
D
W
K
S
A
T
N
L
P
Q
L
Site 69
S832
L
K
E
L
Y
Q
L
S
K
E
K
A
D
F
T
Site 70
T839
S
K
E
K
A
D
F
T
V
V
A
G
D
E
G
Site 71
S847
V
V
A
G
D
E
G
S
S
T
T
G
G
S
S
Site 72
T849
A
G
D
E
G
S
S
T
T
G
G
S
S
E
E
Site 73
S853
G
S
S
T
T
G
G
S
S
E
E
N
K
G
P
Site 74
S854
S
S
T
T
G
G
S
S
E
E
N
K
G
P
S
Site 75
S861
S
E
E
N
K
G
P
S
G
S
A
V
S
R
K
Site 76
S871
A
V
S
R
K
A
P
S
K
P
S
A
S
T
K
Site 77
S874
R
K
A
P
S
K
P
S
A
S
T
K
K
A
E
Site 78
S876
A
P
S
K
P
S
A
S
T
K
K
A
E
G
K
Site 79
S885
K
K
A
E
G
K
L
S
N
S
N
S
K
D
G
Site 80
S887
A
E
G
K
L
S
N
S
N
S
K
D
G
N
M
Site 81
S889
G
K
L
S
N
S
N
S
K
D
G
N
M
Q
T
Site 82
T896
S
K
D
G
N
M
Q
T
A
K
P
S
A
M
K
Site 83
S900
N
M
Q
T
A
K
P
S
A
M
K
V
G
E
K
Site 84
T910
K
V
G
E
K
L
A
T
K
S
S
P
V
K
V
Site 85
S912
G
E
K
L
A
T
K
S
S
P
V
K
V
G
E
Site 86
S913
E
K
L
A
T
K
S
S
P
V
K
V
G
E
K
Site 87
T927
K
R
K
A
A
D
E
T
L
C
Q
T
K
V
L
Site 88
S948
V
R
L
Y
L
P
P
S
T
P
D
F
S
R
L
Site 89
T949
R
L
Y
L
P
P
S
T
P
D
F
S
R
L
R
Site 90
S953
P
P
S
T
P
D
F
S
R
L
R
R
Y
F
V
Site 91
Y958
D
F
S
R
L
R
R
Y
F
V
A
F
D
G
D
Site 92
T976
E
F
D
M
T
S
A
T
H
V
L
G
S
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation