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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
p57Kip2
Full Name:
Cyclin-dependent kinase inhibitor 1C
Alias:
BWCR; BWS; CDKN1C; CDN1C; CDNC; Cyclin-dependent kinase inhibitor p57; KIP2; P57; p57, Kip2
Type:
Nuclear receptor co-regulator; Inhibitor protein
Mass (Da):
32177
Number AA:
316
UniProt ID:
P49918
International Prot ID:
IPI00029086
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004861
GO:0045735
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000080
GO:0007050
GO:0050680
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
S
D
A
S
L
R
S
T
S
T
M
E
R
L
V
Site 2
S10
D
A
S
L
R
S
T
S
T
M
E
R
L
V
A
Site 3
T11
A
S
L
R
S
T
S
T
M
E
R
L
V
A
R
Site 4
S32
V
R
T
S
A
C
R
S
L
F
G
P
V
D
H
Site 5
Y63
E
D
Q
N
R
W
D
Y
D
F
Q
Q
D
M
P
Site 6
T80
G
P
G
R
L
Q
W
T
E
V
D
S
D
S
V
Site 7
S84
L
Q
W
T
E
V
D
S
D
S
V
P
A
F
Y
Site 8
S86
W
T
E
V
D
S
D
S
V
P
A
F
Y
R
E
Site 9
T94
V
P
A
F
Y
R
E
T
V
Q
V
G
R
C
R
Site 10
S125
P
L
E
P
A
A
E
S
L
D
G
L
E
E
A
Site 11
S138
E
A
P
E
Q
L
P
S
V
P
V
P
A
P
A
Site 12
S247
D
Q
L
H
S
G
I
S
G
R
P
A
A
G
T
Site 13
T254
S
G
R
P
A
A
G
T
A
A
A
S
A
N
G
Site 14
S268
G
A
A
I
K
K
L
S
G
P
L
I
S
D
F
Site 15
S273
K
L
S
G
P
L
I
S
D
F
F
A
K
R
K
Site 16
S282
F
F
A
K
R
K
R
S
A
P
E
K
S
S
G
Site 17
S287
K
R
S
A
P
E
K
S
S
G
D
V
P
A
P
Site 18
S288
R
S
A
P
E
K
S
S
G
D
V
P
A
P
C
Site 19
S299
P
A
P
C
P
S
P
S
A
A
P
G
V
G
S
Site 20
S306
S
A
A
P
G
V
G
S
V
E
Q
T
P
R
K
Site 21
T310
G
V
G
S
V
E
Q
T
P
R
K
R
L
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation