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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MRE11A
Full Name:
Double-strand break repair protein MRE11A
Alias:
ATLD; AT-like disease; HNGS1; MmMRE11A; MRE11; MRE11 homolog 1; MRE11 meiotic recombination 11 A; MRE11 meiotic recombination 11 homolog A
Type:
Deoxyribonuclease; DNA binding protein; Cell cycle regulation; DNA repair
Mass (Da):
80593
Number AA:
708
UniProt ID:
P49959
International Prot ID:
IPI00029159
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030870
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008408
GO:0003690
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0032508
GO:0006303
GO:0033674
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
T
A
D
A
L
D
D
Site 2
T12
D
A
L
D
D
E
N
T
F
K
I
L
V
A
T
Site 3
T36
D
A
V
R
G
N
D
T
F
V
T
L
D
E
I
Site 4
T39
R
G
N
D
T
F
V
T
L
D
E
I
L
R
L
Site 5
S68
L
F
H
E
N
K
P
S
R
K
T
L
H
T
C
Site 6
T71
E
N
K
P
S
R
K
T
L
H
T
C
L
E
L
Site 7
T74
P
S
R
K
T
L
H
T
C
L
E
L
L
R
K
Site 8
Y82
C
L
E
L
L
R
K
Y
C
M
G
D
R
P
V
Site 9
S95
P
V
Q
F
E
I
L
S
D
Q
S
V
N
F
G
Site 10
S98
F
E
I
L
S
D
Q
S
V
N
F
G
F
S
K
Site 11
Y111
S
K
F
P
W
V
N
Y
Q
D
G
N
L
N
I
Site 12
T133
H
G
N
H
D
D
P
T
G
A
D
A
L
C
A
Site 13
S158
N
H
F
G
R
S
M
S
V
E
K
I
D
I
S
Site 14
S165
S
V
E
K
I
D
I
S
P
V
L
L
Q
K
G
Site 15
S183
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Site 16
Y190
S
I
P
D
E
R
L
Y
R
M
F
V
N
K
K
Site 17
S225
Q
N
R
S
K
H
G
S
T
N
F
I
P
E
Q
Site 18
Y262
K
N
E
Q
Q
L
F
Y
I
S
Q
P
G
S
S
Site 19
S264
E
Q
Q
L
F
Y
I
S
Q
P
G
S
S
V
V
Site 20
S269
Y
I
S
Q
P
G
S
S
V
V
T
S
L
S
P
Site 21
T272
Q
P
G
S
S
V
V
T
S
L
S
P
G
E
A
Site 22
S273
P
G
S
S
V
V
T
S
L
S
P
G
E
A
V
Site 23
S275
S
S
V
V
T
S
L
S
P
G
E
A
V
K
K
Site 24
T329
N
P
D
N
P
K
V
T
Q
A
I
Q
S
F
C
Site 25
S334
K
V
T
Q
A
I
Q
S
F
C
L
E
K
I
E
Site 26
Y369
L
V
R
L
R
V
D
Y
S
G
G
F
E
P
F
Site 27
S370
V
R
L
R
V
D
Y
S
G
G
F
E
P
F
S
Site 28
S377
S
G
G
F
E
P
F
S
V
L
R
F
S
Q
K
Site 29
S382
P
F
S
V
L
R
F
S
Q
K
F
V
D
R
V
Site 30
S422
G
K
L
I
T
K
P
S
E
G
T
T
L
R
V
Site 31
T426
T
K
P
S
E
G
T
T
L
R
V
E
D
L
V
Site 32
Y436
V
E
D
L
V
K
Q
Y
F
Q
T
A
E
K
N
Site 33
T450
N
V
Q
L
S
L
L
T
E
R
G
M
G
E
A
Site 34
Y476
A
I
E
E
L
V
K
Y
Q
L
E
K
T
Q
R
Site 35
T481
V
K
Y
Q
L
E
K
T
Q
R
F
L
K
E
R
Site 36
T507
E
V
R
R
F
R
E
T
R
Q
K
N
T
N
E
Site 37
S531
T
R
A
R
A
L
R
S
Q
S
E
E
S
A
S
Site 38
S533
A
R
A
L
R
S
Q
S
E
E
S
A
S
A
F
Site 39
S536
L
R
S
Q
S
E
E
S
A
S
A
F
S
A
D
Site 40
S538
S
Q
S
E
E
S
A
S
A
F
S
A
D
D
L
Site 41
S558
A
E
Q
M
A
N
D
S
D
D
S
I
S
A
A
Site 42
S561
M
A
N
D
S
D
D
S
I
S
A
A
T
N
K
Site 43
S563
N
D
S
D
D
S
I
S
A
A
T
N
K
G
R
Site 44
S584
R
G
G
R
G
Q
N
S
A
S
R
G
G
S
Q
Site 45
S586
G
R
G
Q
N
S
A
S
R
G
G
S
Q
R
G
Site 46
S590
N
S
A
S
R
G
G
S
Q
R
G
R
A
D
T
Site 47
T597
S
Q
R
G
R
A
D
T
G
L
E
T
S
T
R
Site 48
T601
R
A
D
T
G
L
E
T
S
T
R
S
R
N
S
Site 49
S602
A
D
T
G
L
E
T
S
T
R
S
R
N
S
K
Site 50
T603
D
T
G
L
E
T
S
T
R
S
R
N
S
K
T
Site 51
S605
G
L
E
T
S
T
R
S
R
N
S
K
T
A
V
Site 52
S608
T
S
T
R
S
R
N
S
K
T
A
V
S
A
S
Site 53
T610
T
R
S
R
N
S
K
T
A
V
S
A
S
R
N
Site 54
S613
R
N
S
K
T
A
V
S
A
S
R
N
M
S
I
Site 55
S615
S
K
T
A
V
S
A
S
R
N
M
S
I
I
D
Site 56
S619
V
S
A
S
R
N
M
S
I
I
D
A
F
K
S
Site 57
S626
S
I
I
D
A
F
K
S
T
R
Q
Q
P
S
R
Site 58
T636
Q
Q
P
S
R
N
V
T
T
K
N
Y
S
E
V
Site 59
S641
N
V
T
T
K
N
Y
S
E
V
I
E
V
D
E
Site 60
S649
E
V
I
E
V
D
E
S
D
V
E
E
D
I
F
Site 61
S660
E
D
I
F
P
T
T
S
K
T
D
Q
R
W
S
Site 62
T662
I
F
P
T
T
S
K
T
D
Q
R
W
S
S
T
Site 63
S667
S
K
T
D
Q
R
W
S
S
T
S
S
S
K
I
Site 64
S668
K
T
D
Q
R
W
S
S
T
S
S
S
K
I
M
Site 65
T669
T
D
Q
R
W
S
S
T
S
S
S
K
I
M
S
Site 66
S670
D
Q
R
W
S
S
T
S
S
S
K
I
M
S
Q
Site 67
S671
Q
R
W
S
S
T
S
S
S
K
I
M
S
Q
S
Site 68
S672
R
W
S
S
T
S
S
S
K
I
M
S
Q
S
Q
Site 69
S676
T
S
S
S
K
I
M
S
Q
S
Q
V
S
K
G
Site 70
S678
S
S
K
I
M
S
Q
S
Q
V
S
K
G
V
D
Site 71
S681
I
M
S
Q
S
Q
V
S
K
G
V
D
F
E
S
Site 72
S688
S
K
G
V
D
F
E
S
S
E
D
D
D
D
D
Site 73
S689
K
G
V
D
F
E
S
S
E
D
D
D
D
D
P
Site 74
T700
D
D
D
P
F
M
N
T
S
S
L
R
R
N
R
Site 75
S701
D
D
P
F
M
N
T
S
S
L
R
R
N
R
R
Site 76
S702
D
P
F
M
N
T
S
S
L
R
R
N
R
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation