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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HNMT
Full Name:
Histamine N-methyltransferase
Alias:
HMT
Type:
EC 2.1.1.8; Amino Acid Metabolism - histidine; Methyltransferase
Mass (Da):
33277
Number AA:
292
UniProt ID:
P50135
International Prot ID:
IPI00030023
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0046539
PhosphoSite+
KinaseNET
Biological Process:
GO:0007585
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
S
M
R
S
L
F
S
Site 2
S7
_
M
A
S
S
M
R
S
L
F
S
D
H
G
K
Site 3
S10
S
S
M
R
S
L
F
S
D
H
G
K
Y
V
E
Site 4
Y15
L
F
S
D
H
G
K
Y
V
E
S
F
R
R
F
Site 5
S18
D
H
G
K
Y
V
E
S
F
R
R
F
L
N
H
Site 6
S52
G
R
I
G
D
T
K
S
E
I
K
I
L
S
I
Site 7
S58
K
S
E
I
K
I
L
S
I
G
G
G
A
G
E
Site 8
Y78
L
S
K
V
Q
A
Q
Y
P
G
V
C
I
N
N
Site 9
Y98
S
A
E
Q
I
A
K
Y
K
E
L
V
A
K
T
Site 10
S121
A
W
H
K
E
T
S
S
E
Y
Q
S
R
M
L
Site 11
Y123
H
K
E
T
S
S
E
Y
Q
S
R
M
L
E
K
Site 12
S125
E
T
S
S
E
Y
Q
S
R
M
L
E
K
K
E
Site 13
S174
K
M
L
I
I
V
V
S
G
S
S
G
W
D
K
Site 14
S176
L
I
I
V
V
S
G
S
S
G
W
D
K
L
W
Site 15
S177
I
I
V
V
S
G
S
S
G
W
D
K
L
W
K
Site 16
Y186
W
D
K
L
W
K
K
Y
G
S
R
F
P
Q
D
Site 17
Y198
P
Q
D
D
L
C
Q
Y
I
T
S
D
D
L
T
Site 18
T205
Y
I
T
S
D
D
L
T
Q
M
L
D
N
L
G
Site 19
Y215
L
D
N
L
G
L
K
Y
E
C
Y
D
L
L
S
Site 20
Y218
L
G
L
K
Y
E
C
Y
D
L
L
S
T
M
D
Site 21
S272
D
L
Q
E
P
E
F
S
A
K
K
E
G
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation