PhosphoNET

           
Protein Info 
   
Short Name:  5-HT(6)
Full Name:  5-hydroxytryptamine receptor 6
Alias:  5-HT6; 5HT6R; HTR6
Type:  Receptor - G protein-coupled; Plasma membrane
Mass (Da):  46954
Number AA:  440
UniProt ID:  P50406
International Prot ID:  IPI00032009
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005887     Uniprot OncoNet
Molecular Function:  GO:0004969  GO:0005515   PhosphoSite+ KinaseNET
Biological Process:  GO:0007187  GO:0007268   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T8MVPEPGPTANSTPAW
Site 2S11EPGPTANSTPAWGAG
Site 3T12PGPTANSTPAWGAGP
Site 4S21AWGAGPPSAPGGSGW
Site 5T60TQPALRNTSNFFLVS
Site 6Y125CLISLDRYLLILSPL
Site 7S130DRYLLILSPLRYKLR
Site 8S185GQCRLLASLPFVLVA
Site 9S201GLTFFLPSGAICFTY
Site 10T207PSGAICFTYCRILLA
Site 11S231SLTTGMASQASETLQ
Site 12T242ETLQVPRTPRPGVES
Site 13S249TPRPGVESADSRRLA
Site 14S252PGVESADSRRLATKH
Site 15T257ADSRRLATKHSRKAL
Site 16S260RRLATKHSRKALKAS
Site 17Y310DVLTWLGYCNSTMNP
Site 18S347CPRERQASLASPSLR
Site 19S350ERQASLASPSLRTSH
Site 20S352QASLASPSLRTSHSG
Site 21S356ASPSLRTSHSGPRPG
Site 22S358PSLRTSHSGPRPGLS
Site 23S365SGPRPGLSLQQVLPL
Site 24S378PLPLPPDSDSDSDAG
Site 25S380PLPPDSDSDSDAGSG
Site 26S382PPDSDSDSDAGSGGS
Site 27S386DSDSDAGSGGSSGLR
Site 28S390DAGSGGSSGLRLTAQ
Site 29T405LLLPGEATQDPPLPT
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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