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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MetAP2
Full Name:
Methionine aminopeptidase 2
Alias:
AMPM2; EC 3.4.11.18; Initiation factor 2-associated 67 kDa glycoprotein; MAP2; MetAP 2; Methionyl aminopeptidase 2; MNPEP; P67; P67eIF2; Peptidase M 2
Type:
EC 3.4.11.18; Protease
Mass (Da):
52892
Number AA:
478
UniProt ID:
P50579
International Prot ID:
IPI00033036
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0050897
GO:0008235
PhosphoSite+
KinaseNET
Biological Process:
GO:0031365
GO:0018206
GO:0016485
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
V
E
E
V
A
A
S
G
S
H
L
N
G
D
Site 2
S29
D
R
E
E
G
A
A
S
T
A
E
E
A
A
K
Site 3
T30
R
E
E
G
A
A
S
T
A
E
E
A
A
K
K
Site 4
S45
K
R
R
K
K
K
K
S
K
G
P
S
A
A
G
Site 5
S49
K
K
K
S
K
G
P
S
A
A
G
E
Q
E
P
Site 6
S60
E
Q
E
P
D
K
E
S
G
A
S
V
D
E
V
Site 7
S63
P
D
K
E
S
G
A
S
V
D
E
V
A
R
Q
Site 8
S74
V
A
R
Q
L
E
R
S
A
L
E
D
K
E
R
Site 9
T96
D
G
D
G
D
G
A
T
G
K
K
K
K
K
K
Site 10
T113
K
R
G
P
K
V
Q
T
D
P
P
S
V
P
I
Site 11
S117
K
V
Q
T
D
P
P
S
V
P
I
C
D
L
Y
Site 12
Y137
P
K
G
Q
E
C
E
Y
P
P
T
Q
D
G
R
Site 13
T140
Q
E
C
E
Y
P
P
T
Q
D
G
R
T
A
A
Site 14
T145
P
P
T
Q
D
G
R
T
A
A
W
R
T
T
S
Site 15
T151
R
T
A
A
W
R
T
T
S
E
E
K
K
A
L
Site 16
S152
T
A
A
W
R
T
T
S
E
E
K
K
A
L
D
Site 17
S162
K
K
A
L
D
Q
A
S
E
E
I
W
N
D
F
Site 18
Y182
A
H
R
Q
V
R
K
Y
V
M
S
W
I
K
P
Site 19
T233
N
N
C
A
A
H
Y
T
P
N
A
G
D
T
T
Site 20
T240
T
P
N
A
G
D
T
T
V
L
Q
Y
D
D
I
Site 21
T268
I
D
C
A
F
T
V
T
F
N
P
K
Y
D
T
Site 22
T284
L
K
A
V
K
D
A
T
N
T
G
I
K
C
A
Site 23
S310
A
I
Q
E
V
M
E
S
Y
E
V
E
I
D
G
Site 24
T319
E
V
E
I
D
G
K
T
Y
Q
V
K
P
I
R
Site 25
Y336
N
G
H
S
I
G
Q
Y
R
I
H
A
G
K
T
Site 26
T343
Y
R
I
H
A
G
K
T
V
P
I
V
K
G
G
Site 27
Y361
R
M
E
E
G
E
V
Y
A
I
E
T
F
G
S
Site 28
T365
G
E
V
Y
A
I
E
T
F
G
S
T
G
K
G
Site 29
T369
A
I
E
T
F
G
S
T
G
K
G
V
V
H
D
Site 30
Y383
D
D
M
E
C
S
H
Y
M
K
N
F
D
V
G
Site 31
Y428
D
R
L
G
E
S
K
Y
L
M
A
L
K
N
L
Site 32
Y454
L
C
D
I
K
G
S
Y
T
A
Q
F
E
H
T
Site 33
T467
H
T
I
L
L
R
P
T
C
K
E
V
V
S
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation