PhosphoNET

           
Protein Info 
   
Short Name:  TOB1
Full Name:  Protein Tob1
Alias:  PIG49; Transducer of erbB-2 1
Type:  Adaptor/scaffold; Cell cycle regulation
Mass (Da):  38155
Number AA:  345
UniProt ID:  P50616
International Prot ID:  IPI00000687
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005070     PhosphoSite+ KinaseNET
Biological Process:  GO:0008285     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y40ERLLKKKYEGHWYPE
Site 2Y45KKYEGHWYPEKPYKG
Site 3S91GNLPQDLSVWIDPFE
Site 4Y113KGPVKVLYVDDNNEN
Site 5S131LDKEIKNSFNPEAQV
Site 6S147MPISDPASSVSSSPS
Site 7S148PISDPASSVSSSPSP
Site 8S150SDPASSVSSSPSPPF
Site 9S151DPASSVSSSPSPPFG
Site 10S152PASSVSSSPSPPFGH
Site 11S154SSVSSSPSPPFGHSA
Site 12S160PSPPFGHSAAVSPTF
Site 13S164FGHSAAVSPTFMPRS
Site 14T166HSAAVSPTFMPRSTQ
Site 15S171SPTFMPRSTQPLTFT
Site 16T172PTFMPRSTQPLTFTT
Site 17T176PRSTQPLTFTTATFA
Site 18S189FAATKFGSTKMKNSG
Site 19S195GSTKMKNSGRSNKVA
Site 20T204RSNKVARTSPINLGL
Site 21S205SNKVARTSPINLGLN
Site 22S223LLKQKAISSSMHSLY
Site 23S224LKQKAISSSMHSLYG
Site 24S225KQKAISSSMHSLYGL
Site 25Y230SSSMHSLYGLGLGSQ
Site 26S236LYGLGLGSQQQPQQQ
Site 27T264QQQQQQKTSALSPNA
Site 28S268QQKTSALSPNAKEFI
Site 29T286MQGQGSSTNGMFPGD
Site 30S294NGMFPGDSPLNLSPL
Site 31S299GDSPLNLSPLQYSNA
Site 32S320YGGLNEKSFVDGLNF
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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