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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FXR1
Full Name:
Fragile X mental retardation syndrome-related protein 1
Alias:
Fragile X mental retardation syndrome related protein 1; Fragile X mental retardation syndrome-related protein 1; Fragile X mental retardation, autosomal 1; HFXR1p
Type:
RNA binding protein
Mass (Da):
69721
Number AA:
621
UniProt ID:
P51114
International Prot ID:
IPI00016249
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005844
Uniprot
OncoNet
Molecular Function:
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0030154
GO:0007517
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
T
V
E
V
R
G
S
N
G
A
F
Y
K
G
Site 2
Y16
R
G
S
N
G
A
F
Y
K
G
F
I
K
D
V
Site 3
S27
I
K
D
V
H
E
D
S
L
T
V
V
F
E
N
Site 4
T29
D
V
H
E
D
S
L
T
V
V
F
E
N
N
W
Site 5
Y68
E
G
D
E
V
E
V
Y
S
R
A
N
D
Q
E
Site 6
Y103
Y
A
A
C
D
A
T
Y
N
E
I
V
T
F
E
Site 7
T108
A
T
Y
N
E
I
V
T
F
E
R
L
R
P
V
Site 8
T120
R
P
V
N
Q
N
K
T
V
K
K
N
T
F
F
Site 9
T125
N
K
T
V
K
K
N
T
F
F
K
C
T
V
D
Site 10
T130
K
N
T
F
F
K
C
T
V
D
V
P
E
D
L
Site 11
Y161
V
G
A
C
R
I
F
Y
H
P
E
T
T
Q
L
Site 12
S191
L
S
D
M
H
L
R
S
I
R
T
K
L
M
L
Site 13
T259
A
I
E
L
D
E
D
T
G
T
F
R
I
Y
G
Site 14
T261
E
L
D
E
D
T
G
T
F
R
I
Y
G
E
S
Site 15
Y265
D
T
G
T
F
R
I
Y
G
E
S
A
D
A
V
Site 16
S268
T
F
R
I
Y
G
E
S
A
D
A
V
K
K
A
Site 17
Y353
N
V
Q
V
L
L
E
Y
H
I
A
Y
L
K
E
Site 18
Y357
L
L
E
Y
H
I
A
Y
L
K
E
V
E
Q
L
Site 19
S380
E
Q
L
R
Q
I
G
S
R
S
Y
S
G
R
G
Site 20
S382
L
R
Q
I
G
S
R
S
Y
S
G
R
G
R
G
Site 21
Y383
R
Q
I
G
S
R
S
Y
S
G
R
G
R
G
R
Site 22
S384
Q
I
G
S
R
S
Y
S
G
R
G
R
G
R
R
Site 23
Y395
R
G
R
R
G
P
N
Y
T
S
G
Y
G
T
N
Site 24
T396
G
R
R
G
P
N
Y
T
S
G
Y
G
T
N
S
Site 25
S397
R
R
G
P
N
Y
T
S
G
Y
G
T
N
S
E
Site 26
Y399
G
P
N
Y
T
S
G
Y
G
T
N
S
E
L
S
Site 27
T401
N
Y
T
S
G
Y
G
T
N
S
E
L
S
N
P
Site 28
S403
T
S
G
Y
G
T
N
S
E
L
S
N
P
S
E
Site 29
S406
Y
G
T
N
S
E
L
S
N
P
S
E
T
E
S
Site 30
S409
N
S
E
L
S
N
P
S
E
T
E
S
E
R
K
Site 31
T411
E
L
S
N
P
S
E
T
E
S
E
R
K
D
E
Site 32
S413
S
N
P
S
E
T
E
S
E
R
K
D
E
L
S
Site 33
S420
S
E
R
K
D
E
L
S
D
W
S
L
A
G
E
Site 34
S423
K
D
E
L
S
D
W
S
L
A
G
E
D
D
R
Site 35
S432
A
G
E
D
D
R
D
S
R
H
Q
R
D
S
R
Site 36
S438
D
S
R
H
Q
R
D
S
R
R
R
P
G
G
R
Site 37
S448
R
P
G
G
R
G
R
S
V
S
G
G
R
G
R
Site 38
S450
G
G
R
G
R
S
V
S
G
G
R
G
R
G
G
Site 39
S463
G
G
P
R
G
G
K
S
S
I
S
S
V
L
K
Site 40
S464
G
P
R
G
G
K
S
S
I
S
S
V
L
K
D
Site 41
S466
R
G
G
K
S
S
I
S
S
V
L
K
D
P
D
Site 42
S467
G
G
K
S
S
I
S
S
V
L
K
D
P
D
S
Site 43
S474
S
V
L
K
D
P
D
S
N
P
Y
S
L
L
D
Site 44
Y477
K
D
P
D
S
N
P
Y
S
L
L
D
N
T
E
Site 45
S478
D
P
D
S
N
P
Y
S
L
L
D
N
T
E
S
Site 46
T483
P
Y
S
L
L
D
N
T
E
S
D
Q
T
A
D
Site 47
S485
S
L
L
D
N
T
E
S
D
Q
T
A
D
T
D
Site 48
T488
D
N
T
E
S
D
Q
T
A
D
T
D
A
S
E
Site 49
T491
E
S
D
Q
T
A
D
T
D
A
S
E
S
H
H
Site 50
S494
Q
T
A
D
T
D
A
S
E
S
H
H
S
T
N
Site 51
S496
A
D
T
D
A
S
E
S
H
H
S
T
N
R
R
Site 52
S499
D
A
S
E
S
H
H
S
T
N
R
R
R
R
S
Site 53
T500
A
S
E
S
H
H
S
T
N
R
R
R
R
S
R
Site 54
S506
S
T
N
R
R
R
R
S
R
R
R
R
T
D
E
Site 55
T511
R
R
S
R
R
R
R
T
D
E
D
A
V
L
M
Site 56
S524
L
M
D
G
M
T
E
S
D
T
A
S
V
N
E
Site 57
T526
D
G
M
T
E
S
D
T
A
S
V
N
E
N
G
Site 58
S528
M
T
E
S
D
T
A
S
V
N
E
N
G
L
V
Site 59
T536
V
N
E
N
G
L
V
T
V
A
D
Y
I
S
R
Site 60
Y540
G
L
V
T
V
A
D
Y
I
S
R
A
E
S
Q
Site 61
S542
V
T
V
A
D
Y
I
S
R
A
E
S
Q
S
R
Site 62
S546
D
Y
I
S
R
A
E
S
Q
S
R
Q
R
N
L
Site 63
S548
I
S
R
A
E
S
Q
S
R
Q
R
N
L
P
R
Site 64
T557
Q
R
N
L
P
R
E
T
L
A
K
N
K
K
E
Site 65
S576
V
I
E
E
H
G
P
S
E
K
A
I
N
G
P
Site 66
S585
K
A
I
N
G
P
T
S
A
S
G
D
D
I
S
Site 67
S587
I
N
G
P
T
S
A
S
G
D
D
I
S
K
L
Site 68
S592
S
A
S
G
D
D
I
S
K
L
Q
R
T
P
G
Site 69
T597
D
I
S
K
L
Q
R
T
P
G
E
E
K
I
N
Site 70
T605
P
G
E
E
K
I
N
T
L
K
E
E
N
T
Q
Site 71
T611
N
T
L
K
E
E
N
T
Q
E
A
A
V
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation