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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FXR2
Full Name:
Fragile X mental retardation syndrome-related protein 2
Alias:
FMR1L2; fragile X mental retardation syndrome related protein 2; fragile X mental retardation, autosomal 2
Type:
RNA binding protein
Mass (Da):
74223
Number AA:
673
UniProt ID:
P51116
International Prot ID:
IPI00016250
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0022625
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
G
L
A
S
G
G
D
V
E
P
G
Site 2
S21
L
P
V
E
V
R
G
S
N
G
A
F
Y
K
G
Site 3
Y26
R
G
S
N
G
A
F
Y
K
G
F
V
K
D
V
Site 4
S37
V
K
D
V
H
E
D
S
V
T
I
F
F
E
N
Site 5
Y65
R
L
P
P
P
A
D
Y
N
K
E
I
T
E
G
Site 6
T70
A
D
Y
N
K
E
I
T
E
G
D
E
V
E
V
Site 7
Y78
E
G
D
E
V
E
V
Y
S
R
A
N
E
Q
E
Site 8
Y113
Y
A
A
C
D
A
T
Y
N
E
I
V
T
L
E
Site 9
T118
A
T
Y
N
E
I
V
T
L
E
R
L
R
P
V
Site 10
S135
N
P
L
A
T
K
G
S
F
F
K
V
T
M
A
Site 11
S152
E
D
L
R
E
A
C
S
N
E
N
V
H
K
E
Site 12
T174
N
C
I
F
L
N
I
T
N
S
E
L
F
I
L
Site 13
S182
N
S
E
L
F
I
L
S
T
T
E
A
P
V
K
Site 14
S192
E
A
P
V
K
R
A
S
L
L
G
D
M
H
F
Site 15
T216
M
S
R
N
E
E
A
T
K
H
L
E
T
S
K
Site 16
T234
A
A
F
Q
E
E
F
T
V
R
E
D
L
M
G
Site 17
T271
E
L
G
E
E
T
C
T
F
R
I
Y
G
E
T
Site 18
Y275
E
T
C
T
F
R
I
Y
G
E
T
P
E
A
C
Site 19
T278
T
F
R
I
Y
G
E
T
P
E
A
C
R
Q
A
Site 20
S287
E
A
C
R
Q
A
R
S
Y
L
E
F
S
E
D
Site 21
Y288
A
C
R
Q
A
R
S
Y
L
E
F
S
E
D
S
Site 22
S295
Y
L
E
F
S
E
D
S
V
Q
V
P
R
N
L
Site 23
T350
V
P
F
I
F
V
G
T
R
E
N
I
S
N
A
Site 24
S366
A
L
L
E
Y
H
L
S
Y
L
Q
E
V
E
Q
Site 25
S397
L
G
F
R
P
P
G
S
G
R
G
S
G
G
S
Site 26
S401
P
P
G
S
G
R
G
S
G
G
S
D
K
A
G
Site 27
S404
S
G
R
G
S
G
G
S
D
K
A
G
Y
S
T
Site 28
Y409
G
G
S
D
K
A
G
Y
S
T
D
E
S
S
S
Site 29
S410
G
S
D
K
A
G
Y
S
T
D
E
S
S
S
S
Site 30
T411
S
D
K
A
G
Y
S
T
D
E
S
S
S
S
S
Site 31
S414
A
G
Y
S
T
D
E
S
S
S
S
S
L
H
A
Site 32
S415
G
Y
S
T
D
E
S
S
S
S
S
L
H
A
T
Site 33
S417
S
T
D
E
S
S
S
S
S
L
H
A
T
R
T
Site 34
S418
T
D
E
S
S
S
S
S
L
H
A
T
R
T
Y
Site 35
T422
S
S
S
S
L
H
A
T
R
T
Y
G
G
S
Y
Site 36
T424
S
S
L
H
A
T
R
T
Y
G
G
S
Y
G
G
Site 37
Y425
S
L
H
A
T
R
T
Y
G
G
S
Y
G
G
R
Site 38
S428
A
T
R
T
Y
G
G
S
Y
G
G
R
G
R
G
Site 39
Y429
T
R
T
Y
G
G
S
Y
G
G
R
G
R
G
R
Site 40
T438
G
R
G
R
G
R
R
T
G
G
P
A
Y
G
P
Site 41
Y443
R
R
T
G
G
P
A
Y
G
P
S
S
D
V
S
Site 42
S446
G
G
P
A
Y
G
P
S
S
D
V
S
T
A
S
Site 43
S447
G
P
A
Y
G
P
S
S
D
V
S
T
A
S
E
Site 44
S450
Y
G
P
S
S
D
V
S
T
A
S
E
T
E
S
Site 45
T451
G
P
S
S
D
V
S
T
A
S
E
T
E
S
E
Site 46
S453
S
S
D
V
S
T
A
S
E
T
E
S
E
K
R
Site 47
T455
D
V
S
T
A
S
E
T
E
S
E
K
R
E
E
Site 48
S457
S
T
A
S
E
T
E
S
E
K
R
E
E
P
N
Site 49
T475
P
G
D
R
D
P
P
T
R
G
E
E
S
R
R
Site 50
S480
P
P
T
R
G
E
E
S
R
R
R
P
T
G
G
Site 51
T485
E
E
S
R
R
R
P
T
G
G
R
G
R
G
P
Site 52
T499
P
P
P
A
P
R
P
T
S
R
Y
N
S
S
S
Site 53
S500
P
P
A
P
R
P
T
S
R
Y
N
S
S
S
I
Site 54
Y502
A
P
R
P
T
S
R
Y
N
S
S
S
I
S
S
Site 55
S504
R
P
T
S
R
Y
N
S
S
S
I
S
S
V
L
Site 56
S505
P
T
S
R
Y
N
S
S
S
I
S
S
V
L
K
Site 57
S506
T
S
R
Y
N
S
S
S
I
S
S
V
L
K
D
Site 58
S508
R
Y
N
S
S
S
I
S
S
V
L
K
D
P
D
Site 59
S509
Y
N
S
S
S
I
S
S
V
L
K
D
P
D
S
Site 60
S516
S
V
L
K
D
P
D
S
N
P
Y
S
L
L
D
Site 61
Y519
K
D
P
D
S
N
P
Y
S
L
L
D
T
S
E
Site 62
S520
D
P
D
S
N
P
Y
S
L
L
D
T
S
E
P
Site 63
T524
N
P
Y
S
L
L
D
T
S
E
P
E
P
P
V
Site 64
S525
P
Y
S
L
L
D
T
S
E
P
E
P
P
V
D
Site 65
S533
E
P
E
P
P
V
D
S
E
P
G
E
P
P
P
Site 66
S542
P
G
E
P
P
P
A
S
A
R
R
R
R
S
R
Site 67
S548
A
S
A
R
R
R
R
S
R
R
R
R
T
D
E
Site 68
T553
R
R
S
R
R
R
R
T
D
E
D
R
T
V
M
Site 69
T558
R
R
T
D
E
D
R
T
V
M
D
G
G
L
E
Site 70
S566
V
M
D
G
G
L
E
S
D
G
P
N
M
T
E
Site 71
S588
R
P
Q
R
R
N
R
S
R
R
R
R
N
R
G
Site 72
T598
R
R
N
R
G
N
R
T
D
G
S
I
S
G
D
Site 73
S601
R
G
N
R
T
D
G
S
I
S
G
D
R
Q
P
Site 74
S603
N
R
T
D
G
S
I
S
G
D
R
Q
P
V
T
Site 75
T610
S
G
D
R
Q
P
V
T
V
A
D
Y
I
S
R
Site 76
Y614
Q
P
V
T
V
A
D
Y
I
S
R
A
E
S
Q
Site 77
S616
V
T
V
A
D
Y
I
S
R
A
E
S
Q
S
R
Site 78
S620
D
Y
I
S
R
A
E
S
Q
S
R
Q
R
P
P
Site 79
S622
I
S
R
A
E
S
Q
S
R
Q
R
P
P
L
E
Site 80
S634
P
L
E
R
T
K
P
S
E
D
S
L
S
G
Q
Site 81
S637
R
T
K
P
S
E
D
S
L
S
G
Q
K
G
D
Site 82
S639
K
P
S
E
D
S
L
S
G
Q
K
G
D
S
V
Site 83
S645
L
S
G
Q
K
G
D
S
V
S
K
L
P
K
G
Site 84
S647
G
Q
K
G
D
S
V
S
K
L
P
K
G
P
S
Site 85
S654
S
K
L
P
K
G
P
S
E
N
G
E
L
S
A
Site 86
S660
P
S
E
N
G
E
L
S
A
P
L
E
L
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation