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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE6C
Full Name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Alias:
CGMP phosphodiesterase 6C; Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'; EC 3.1.4.35; PDEA2; Phosphodiesterase 6C, cGMP-specific, cone, alpha prime
Type:
Phosphodiesterase; EC 3.1.4.35
Mass (Da):
99147
Number AA:
858
UniProt ID:
P51160
International Prot ID:
IPI00747459
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0047555
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
N
Q
V
A
V
E
K
Y
L
E
E
N
P
Q
F
Site 2
Y23
N
P
Q
F
A
K
E
Y
F
D
R
K
L
R
V
Site 3
S40
L
G
E
I
F
K
N
S
Q
V
P
V
Q
S
S
Site 4
S46
N
S
Q
V
P
V
Q
S
S
M
S
F
S
E
L
Site 5
S47
S
Q
V
P
V
Q
S
S
M
S
F
S
E
L
T
Site 6
S51
V
Q
S
S
M
S
F
S
E
L
T
Q
V
E
E
Site 7
T54
S
M
S
F
S
E
L
T
Q
V
E
E
S
A
L
Site 8
T75
T
V
Q
E
E
G
G
T
P
E
Q
G
V
H
R
Site 9
S97
L
L
Q
A
D
R
C
S
M
F
L
C
R
S
R
Site 10
T118
A
S
R
L
L
D
V
T
P
T
S
K
F
E
D
Site 11
S121
L
L
D
V
T
P
T
S
K
F
E
D
N
L
V
Site 12
S162
V
P
D
V
K
K
N
S
H
F
S
D
F
M
D
Site 13
T172
S
D
F
M
D
K
Q
T
G
Y
V
T
K
N
L
Site 14
Y174
F
M
D
K
Q
T
G
Y
V
T
K
N
L
L
A
Site 15
Y231
L
R
L
H
H
T
S
Y
M
Y
N
I
E
S
R
Site 16
S240
Y
N
I
E
S
R
R
S
Q
I
L
M
W
S
A
Site 17
Y266
R
Q
F
H
K
A
L
Y
T
V
R
S
Y
L
N
Site 18
T267
Q
F
H
K
A
L
Y
T
V
R
S
Y
L
N
C
Site 19
S270
K
A
L
Y
T
V
R
S
Y
L
N
C
E
R
Y
Site 20
Y271
A
L
Y
T
V
R
S
Y
L
N
C
E
R
Y
S
Site 21
Y277
S
Y
L
N
C
E
R
Y
S
I
G
L
L
D
M
Site 22
T285
S
I
G
L
L
D
M
T
K
E
K
E
F
Y
D
Site 23
Y291
M
T
K
E
K
E
F
Y
D
E
W
P
I
K
L
Site 24
Y304
K
L
G
E
V
E
P
Y
K
G
P
K
T
P
D
Site 25
T309
E
P
Y
K
G
P
K
T
P
D
G
R
E
V
N
Site 26
Y318
D
G
R
E
V
N
F
Y
K
I
I
D
Y
I
L
Site 27
Y323
N
F
Y
K
I
I
D
Y
I
L
H
G
K
E
E
Site 28
T336
E
E
I
K
V
I
P
T
P
P
A
D
H
W
T
Site 29
T343
T
P
P
A
D
H
W
T
L
I
S
G
L
P
T
Site 30
Y369
M
N
A
P
A
D
E
Y
F
T
F
Q
K
G
P
Site 31
T371
A
P
A
D
E
Y
F
T
F
Q
K
G
P
V
D
Site 32
T380
Q
K
G
P
V
D
E
T
G
W
V
I
K
N
V
Site 33
T404
E
D
I
V
G
V
A
T
F
Y
N
R
K
D
G
Site 34
Y406
I
V
G
V
A
T
F
Y
N
R
K
D
G
K
P
Site 35
Y420
P
F
D
E
H
D
E
Y
I
T
E
T
L
T
Q
Site 36
T436
L
G
W
S
L
L
N
T
D
T
Y
D
K
M
N
Site 37
T438
W
S
L
L
N
T
D
T
Y
D
K
M
N
K
L
Site 38
Y439
S
L
L
N
T
D
T
Y
D
K
M
N
K
L
E
Site 39
T463
L
M
N
Q
T
K
A
T
P
E
E
I
K
S
I
Site 40
S469
A
T
P
E
E
I
K
S
I
L
K
F
Q
E
K
Site 41
S503
E
D
L
P
D
P
R
S
A
E
L
Y
E
F
R
Site 42
Y507
D
P
R
S
A
E
L
Y
E
F
R
F
S
D
F
Site 43
S512
E
L
Y
E
F
R
F
S
D
F
P
L
T
E
H
Site 44
T517
R
F
S
D
F
P
L
T
E
H
G
L
I
K
C
Site 45
Y550
E
V
L
T
R
W
M
Y
T
V
R
K
G
Y
R
Site 46
T551
V
L
T
R
W
M
Y
T
V
R
K
G
Y
R
A
Site 47
Y556
M
Y
T
V
R
K
G
Y
R
A
V
T
Y
H
N
Site 48
Y561
K
G
Y
R
A
V
T
Y
H
N
W
R
H
G
F
Site 49
Y586
M
T
G
R
L
K
K
Y
Y
T
D
L
E
A
F
Site 50
Y587
T
G
R
L
K
K
Y
Y
T
D
L
E
A
F
A
Site 51
T588
G
R
L
K
K
Y
Y
T
D
L
E
A
F
A
M
Site 52
Y613
H
R
G
T
N
N
L
Y
Q
M
K
S
T
S
P
Site 53
S617
N
N
L
Y
Q
M
K
S
T
S
P
L
A
R
L
Site 54
S619
L
Y
Q
M
K
S
T
S
P
L
A
R
L
H
G
Site 55
S628
L
A
R
L
H
G
S
S
I
L
E
R
H
H
L
Site 56
Y637
L
E
R
H
H
L
E
Y
S
K
T
L
L
Q
D
Site 57
T640
H
H
L
E
Y
S
K
T
L
L
Q
D
E
S
L
Site 58
S646
K
T
L
L
Q
D
E
S
L
N
I
F
Q
N
L
Site 59
T696
D
A
C
E
Q
M
Q
T
E
E
E
A
I
K
Y
Site 60
Y703
T
E
E
E
A
I
K
Y
V
T
V
D
P
T
K
Site 61
T705
E
E
A
I
K
Y
V
T
V
D
P
T
K
K
E
Site 62
T754
E
Q
G
D
L
E
R
T
V
L
Q
Q
Q
P
I
Site 63
Y788
D
F
V
C
T
F
V
Y
K
E
F
S
R
F
H
Site 64
T799
S
R
F
H
K
E
I
T
P
M
L
S
G
L
Q
Site 65
S814
N
N
R
V
E
W
K
S
L
A
D
E
Y
D
A
Site 66
Y819
W
K
S
L
A
D
E
Y
D
A
K
M
K
V
I
Site 67
S852
G
G
G
D
D
K
K
S
K
T
C
L
M
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation