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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCD1
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
Alias:
Phosphoinositide phospholipase C; Phospholipase c, delta 1; Phospholipase c, delta 1 isoform 1; Phospholipase c, delta 1 isoform 2; Phospholipase c, delta 1 variant; Phospholipase C-delta-1; Plcd1; PLC-III
Type:
EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase
Mass (Da):
85646
Number AA:
756
UniProt ID:
P51178
International Prot ID:
IPI00746030
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0032794
GO:0005509
GO:0004435
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
GO:0006644
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
S
G
R
D
F
L
T
L
H
G
L
Q
D
D
Site 2
S26
L
Q
A
L
L
K
G
S
Q
L
L
K
V
K
S
Site 3
S33
S
Q
L
L
K
V
K
S
S
S
W
R
R
E
R
Site 4
S34
Q
L
L
K
V
K
S
S
S
W
R
R
E
R
F
Site 5
S35
L
L
K
V
K
S
S
S
W
R
R
E
R
F
Y
Site 6
Y42
S
W
R
R
E
R
F
Y
K
L
Q
E
D
C
K
Site 7
T50
K
L
Q
E
D
C
K
T
I
W
Q
E
S
R
K
Site 8
T61
E
S
R
K
V
M
R
T
P
E
S
Q
L
F
S
Site 9
S64
K
V
M
R
T
P
E
S
Q
L
F
S
I
E
D
Site 10
S68
T
P
E
S
Q
L
F
S
I
E
D
I
Q
E
V
Site 11
T81
E
V
R
M
G
H
R
T
E
G
L
E
K
F
A
Site 12
S98
V
P
E
D
R
C
F
S
I
V
F
K
D
Q
R
Site 13
T107
V
F
K
D
Q
R
N
T
L
D
L
I
A
P
S
Site 14
S114
T
L
D
L
I
A
P
S
P
A
D
A
Q
H
W
Site 15
S161
K
N
K
D
N
K
M
S
F
K
E
L
Q
N
F
Site 16
S179
L
N
I
Q
V
D
D
S
Y
A
R
K
I
F
R
Site 17
Y180
N
I
Q
V
D
D
S
Y
A
R
K
I
F
R
E
Site 18
S191
I
F
R
E
C
D
H
S
Q
T
D
S
L
E
D
Site 19
S195
C
D
H
S
Q
T
D
S
L
E
D
E
E
I
E
Site 20
T209
E
A
F
Y
K
M
L
T
Q
R
V
E
I
D
R
Site 21
T217
Q
R
V
E
I
D
R
T
F
A
E
A
A
G
S
Site 22
S224
T
F
A
E
A
A
G
S
G
E
T
L
S
V
D
Site 23
T235
L
S
V
D
Q
L
V
T
F
L
Q
H
Q
Q
R
Site 24
T263
E
R
Y
E
P
S
E
T
A
K
A
Q
R
Q
M
Site 25
T271
A
K
A
Q
R
Q
M
T
K
D
G
F
L
M
Y
Site 26
S288
S
A
D
G
S
A
F
S
L
A
H
R
R
V
Y
Site 27
Y295
S
L
A
H
R
R
V
Y
Q
D
M
G
Q
P
L
Site 28
S303
Q
D
M
G
Q
P
L
S
H
Y
L
V
S
S
S
Site 29
Y305
M
G
Q
P
L
S
H
Y
L
V
S
S
S
H
N
Site 30
S308
P
L
S
H
Y
L
V
S
S
S
H
N
T
Y
L
Site 31
S310
S
H
Y
L
V
S
S
S
H
N
T
Y
L
L
E
Site 32
S325
D
Q
L
A
G
P
S
S
T
E
A
Y
I
R
A
Site 33
Y329
G
P
S
S
T
E
A
Y
I
R
A
L
C
K
G
Site 34
Y355
P
N
Q
E
P
I
I
Y
H
G
Y
T
F
T
S
Site 35
Y376
V
L
R
A
I
R
D
Y
A
F
K
A
S
P
Y
Site 36
S381
R
D
Y
A
F
K
A
S
P
Y
P
V
I
L
S
Site 37
T394
L
S
L
E
N
H
C
T
L
E
Q
Q
R
V
M
Site 38
T422
N
R
P
L
D
G
V
T
N
S
L
P
S
P
E
Site 39
S424
P
L
D
G
V
T
N
S
L
P
S
P
E
Q
L
Site 40
S427
G
V
T
N
S
L
P
S
P
E
Q
L
K
G
K
Site 41
S460
G
P
E
A
T
V
V
S
D
E
D
E
A
A
E
Site 42
S508
S
V
H
F
G
G
F
S
S
P
G
T
P
G
Q
Site 43
S509
V
H
F
G
G
F
S
S
P
G
T
P
G
Q
A
Site 44
T512
G
G
F
S
S
P
G
T
P
G
Q
A
F
Y
E
Site 45
Y518
G
T
P
G
Q
A
F
Y
E
M
A
S
F
S
E
Site 46
S522
Q
A
F
Y
E
M
A
S
F
S
E
N
R
A
L
Site 47
S524
F
Y
E
M
A
S
F
S
E
N
R
A
L
R
L
Site 48
S535
A
L
R
L
L
Q
E
S
G
N
G
F
V
R
H
Site 49
Y551
V
G
H
L
S
R
I
Y
P
A
G
W
R
T
D
Site 50
T557
I
Y
P
A
G
W
R
T
D
S
S
N
Y
S
P
Site 51
S559
P
A
G
W
R
T
D
S
S
N
Y
S
P
V
E
Site 52
S560
A
G
W
R
T
D
S
S
N
Y
S
P
V
E
M
Site 53
S563
R
T
D
S
S
N
Y
S
P
V
E
M
W
N
G
Site 54
Y589
P
G
P
E
M
D
V
Y
Q
G
R
F
Q
D
N
Site 55
T614
F
L
R
D
P
N
G
T
F
N
P
R
A
L
A
Site 56
S637
R
L
N
I
R
V
I
S
G
Q
Q
L
P
K
V
Site 57
T672
R
D
V
A
S
R
Q
T
A
V
I
T
N
N
G
Site 58
T676
S
R
Q
T
A
V
I
T
N
N
G
F
N
P
W
Site 59
Y707
I
R
F
L
V
E
D
Y
D
A
S
S
K
N
D
Site 60
S711
V
E
D
Y
D
A
S
S
K
N
D
F
I
G
Q
Site 61
S719
K
N
D
F
I
G
Q
S
T
I
P
L
N
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation