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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPMT
Full Name:
Thiopurine S-methyltransferase
Alias:
Thiopurine methyltransferase
Type:
Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.1.1.67; Methyltransferase
Mass (Da):
28180
Number AA:
245
UniProt ID:
P51580
International Prot ID:
IPI00019400
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0008119
GO:0008119
GO:0008168
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
G
T
R
T
S
L
D
I
E
E
Y
S
Site 2
S14
S
L
D
I
E
E
Y
S
D
T
E
V
Q
K
N
Site 3
T16
D
I
E
E
Y
S
D
T
E
V
Q
K
N
Q
V
Site 4
T55
L
L
K
K
H
L
D
T
F
L
K
G
K
S
G
Site 5
S61
D
T
F
L
K
G
K
S
G
L
R
V
F
F
P
Site 6
T101
L
G
I
Q
E
F
F
T
E
Q
N
L
S
Y
S
Site 7
S106
F
F
T
E
Q
N
L
S
Y
S
E
E
P
I
T
Site 8
S108
T
E
Q
N
L
S
Y
S
E
E
P
I
T
E
I
Site 9
T113
S
Y
S
E
E
P
I
T
E
I
P
G
T
K
V
Site 10
T118
P
I
T
E
I
P
G
T
K
V
F
K
S
S
S
Site 11
S123
P
G
T
K
V
F
K
S
S
S
G
N
I
S
L
Site 12
S125
T
K
V
F
K
S
S
S
G
N
I
S
L
Y
C
Site 13
T141
S
I
F
D
L
P
R
T
N
I
G
K
F
D
M
Site 14
Y166
N
P
G
D
R
K
C
Y
A
D
T
M
F
S
L
Site 15
T169
D
R
K
C
Y
A
D
T
M
F
S
L
L
G
K
Site 16
S186
Q
Y
L
L
C
V
L
S
Y
D
P
T
K
H
P
Site 17
T190
C
V
L
S
Y
D
P
T
K
H
P
G
P
P
F
Site 18
Y198
K
H
P
G
P
P
F
Y
V
P
H
A
E
I
E
Site 19
Y240
D
C
L
F
E
K
L
Y
L
L
T
E
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation