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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MeCP2
Full Name:
Methyl-CpG-binding protein 2
Alias:
MEC2; MECP2; MeCP-2 protein; Methyl CpG binding protein 2 (Rett syndrome); MRX16; MRX79; RTT
Type:
Transcription, coactivator/corepressor
Mass (Da):
52441
Number AA:
486
UniProt ID:
P51608
International Prot ID:
IPI00418234
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000792
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0010385
GO:0047485
GO:0019904
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
G
L
R
E
E
K
S
E
D
Q
D
L
Q
G
Site 2
S49
K
H
E
P
V
Q
P
S
A
H
H
S
A
E
P
Site 3
S53
V
Q
P
S
A
H
H
S
A
E
P
A
E
A
G
Site 4
S65
E
A
G
K
A
E
T
S
E
G
S
G
S
A
P
Site 5
S68
K
A
E
T
S
E
G
S
G
S
A
P
A
V
P
Site 6
S70
E
T
S
E
G
S
G
S
A
P
A
V
P
E
A
Site 7
S78
A
P
A
V
P
E
A
S
A
S
P
K
Q
R
R
Site 8
S80
A
V
P
E
A
S
A
S
P
K
Q
R
R
S
I
Site 9
S86
A
S
P
K
Q
R
R
S
I
I
R
D
R
G
P
Site 10
Y95
I
R
D
R
G
P
M
Y
D
D
P
T
L
P
E
Site 11
T99
G
P
M
Y
D
D
P
T
L
P
E
G
W
T
R
Site 12
S113
R
K
L
K
Q
R
K
S
G
R
S
A
G
K
Y
Site 13
S116
K
Q
R
K
S
G
R
S
A
G
K
Y
D
V
Y
Site 14
Y120
S
G
R
S
A
G
K
Y
D
V
Y
L
I
N
P
Site 15
Y123
S
A
G
K
Y
D
V
Y
L
I
N
P
Q
G
K
Site 16
S134
P
Q
G
K
A
F
R
S
K
V
E
L
I
A
Y
Site 17
Y141
S
K
V
E
L
I
A
Y
F
E
K
V
G
D
T
Site 18
T148
Y
F
E
K
V
G
D
T
S
L
D
P
N
D
F
Site 19
S149
F
E
K
V
G
D
T
S
L
D
P
N
D
F
D
Site 20
T158
D
P
N
D
F
D
F
T
V
T
G
R
G
S
P
Site 21
T160
N
D
F
D
F
T
V
T
G
R
G
S
P
S
R
Site 22
S164
F
T
V
T
G
R
G
S
P
S
R
R
E
Q
K
Site 23
S166
V
T
G
R
G
S
P
S
R
R
E
Q
K
P
P
Site 24
S178
K
P
P
K
K
P
K
S
P
K
A
P
G
T
G
Site 25
T184
K
S
P
K
A
P
G
T
G
R
G
R
G
R
P
Site 26
S194
G
R
G
R
P
K
G
S
G
T
T
R
P
K
A
Site 27
T196
G
R
P
K
G
S
G
T
T
R
P
K
A
A
T
Site 28
T203
T
T
R
P
K
A
A
T
S
E
G
V
Q
V
K
Site 29
S216
V
K
R
V
L
E
K
S
P
G
K
L
L
V
K
Site 30
T228
L
V
K
M
P
F
Q
T
S
P
G
G
K
A
E
Site 31
S229
V
K
M
P
F
Q
T
S
P
G
G
K
A
E
G
Site 32
T243
G
G
G
A
T
T
S
T
Q
V
M
V
I
K
R
Site 33
S274
K
R
G
R
K
P
G
S
V
V
A
A
A
A
A
Site 34
S291
K
K
K
A
V
K
E
S
S
I
R
S
V
Q
E
Site 35
S292
K
K
A
V
K
E
S
S
I
R
S
V
Q
E
T
Site 36
S295
V
K
E
S
S
I
R
S
V
Q
E
T
V
L
P
Site 37
T299
S
I
R
S
V
Q
E
T
V
L
P
I
K
K
R
Site 38
T308
L
P
I
K
K
R
K
T
R
E
T
V
S
I
E
Site 39
T311
K
K
R
K
T
R
E
T
V
S
I
E
V
K
E
Site 40
S313
R
K
T
R
E
T
V
S
I
E
V
K
E
V
V
Site 41
T327
V
K
P
L
L
V
S
T
L
G
E
K
S
G
K
Site 42
T338
K
S
G
K
G
L
K
T
C
K
S
P
G
R
K
Site 43
S341
K
G
L
K
T
C
K
S
P
G
R
K
S
K
E
Site 44
S346
C
K
S
P
G
R
K
S
K
E
S
S
P
K
G
Site 45
S349
P
G
R
K
S
K
E
S
S
P
K
G
R
S
S
Site 46
S350
G
R
K
S
K
E
S
S
P
K
G
R
S
S
S
Site 47
S355
E
S
S
P
K
G
R
S
S
S
A
S
S
P
P
Site 48
S356
S
S
P
K
G
R
S
S
S
A
S
S
P
P
K
Site 49
S357
S
P
K
G
R
S
S
S
A
S
S
P
P
K
K
Site 50
S359
K
G
R
S
S
S
A
S
S
P
P
K
K
E
H
Site 51
S360
G
R
S
S
S
A
S
S
P
P
K
K
E
H
H
Site 52
S375
H
H
H
H
H
S
E
S
P
K
A
P
V
P
L
Site 53
S395
P
P
P
P
E
P
E
S
S
E
D
P
T
S
P
Site 54
S396
P
P
P
E
P
E
S
S
E
D
P
T
S
P
P
Site 55
T400
P
E
S
S
E
D
P
T
S
P
P
E
P
Q
D
Site 56
S401
E
S
S
E
D
P
T
S
P
P
E
P
Q
D
L
Site 57
S409
P
P
E
P
Q
D
L
S
S
S
V
C
K
E
E
Site 58
S410
P
E
P
Q
D
L
S
S
S
V
C
K
E
E
K
Site 59
S411
E
P
Q
D
L
S
S
S
V
C
K
E
E
K
M
Site 60
S423
E
K
M
P
R
G
G
S
L
E
S
D
G
C
P
Site 61
S426
P
R
G
G
S
L
E
S
D
G
C
P
K
E
P
Site 62
T436
C
P
K
E
P
A
K
T
Q
P
A
V
A
T
A
Site 63
Y450
A
A
T
A
A
E
K
Y
K
H
R
G
E
G
E
Site 64
S463
G
E
R
K
D
I
V
S
S
S
M
P
R
P
N
Site 65
S464
E
R
K
D
I
V
S
S
S
M
P
R
P
N
R
Site 66
S465
R
K
D
I
V
S
S
S
M
P
R
P
N
R
E
Site 67
S477
N
R
E
E
P
V
D
S
R
T
P
V
T
E
R
Site 68
T479
E
E
P
V
D
S
R
T
P
V
T
E
R
V
S
Site 69
T482
V
D
S
R
T
P
V
T
E
R
V
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation