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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HCFC1
Full Name:
Host cell factor 1
Alias:
C1 factor; CFF; HCF; HCF1; HCF-1; HFC1; Host cell factor; Host cell factor C1 (VP16-accessory protein); MGC70925; VCAF; VP16 accessory
Type:
Transcription, coactivator/corepressor
Mass (Da):
208732
Number AA:
2035
UniProt ID:
P51610
International Prot ID:
IPI00019848
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070688
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0003713
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0045787
GO:0019046
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
S
A
V
S
P
A
N
L
P
A
V
Site 2
S26
W
K
R
V
V
G
W
S
G
P
V
P
R
P
R
Site 3
Y62
I
V
D
E
L
H
V
Y
N
T
A
T
N
Q
W
Site 4
Y103
V
F
G
G
M
V
E
Y
G
K
Y
S
N
D
L
Site 5
Y106
G
M
V
E
Y
G
K
Y
S
N
D
L
Y
E
L
Site 6
Y111
G
K
Y
S
N
D
L
Y
E
L
Q
A
S
R
W
Site 7
T127
W
K
R
L
K
A
K
T
P
K
N
G
P
P
P
Site 8
S141
P
C
P
R
L
G
H
S
F
S
L
V
G
N
K
Site 9
S143
P
R
L
G
H
S
F
S
L
V
G
N
K
C
Y
Site 10
S159
F
G
G
L
A
N
D
S
E
D
P
K
N
N
I
Site 11
Y169
P
K
N
N
I
P
R
Y
L
N
D
L
Y
I
L
Site 12
Y174
P
R
Y
L
N
D
L
Y
I
L
E
L
R
P
G
Site 13
S202
V
L
P
P
P
R
E
S
H
T
A
V
V
Y
T
Site 14
Y221
K
K
S
K
L
V
I
Y
G
G
M
S
G
C
R
Site 15
T239
L
W
T
L
D
I
D
T
L
T
W
N
K
P
S
Site 16
T241
T
L
D
I
D
T
L
T
W
N
K
P
S
L
S
Site 17
S248
T
W
N
K
P
S
L
S
G
V
A
P
L
P
R
Site 18
S256
G
V
A
P
L
P
R
S
L
H
S
A
T
T
I
Site 19
T313
W
E
T
I
L
M
D
T
L
E
D
N
I
P
R
Site 20
Y335
V
A
I
N
T
R
L
Y
I
W
S
G
R
D
G
Site 21
Y343
I
W
S
G
R
D
G
Y
R
K
A
W
N
N
Q
Site 22
Y358
V
C
C
K
D
L
W
Y
L
E
T
E
K
P
P
Site 23
T361
K
D
L
W
Y
L
E
T
E
K
P
P
P
P
A
Site 24
T377
V
Q
L
V
R
A
N
T
N
S
L
E
V
S
W
Site 25
S379
L
V
R
A
N
T
N
S
L
E
V
S
W
G
A
Site 26
S383
N
T
N
S
L
E
V
S
W
G
A
V
A
T
A
Site 27
S392
G
A
V
A
T
A
D
S
Y
L
L
Q
L
Q
K
Site 28
S411
A
T
A
A
T
A
T
S
P
T
P
N
P
V
P
Site 29
T413
A
A
T
A
T
S
P
T
P
N
P
V
P
S
V
Site 30
S419
P
T
P
N
P
V
P
S
V
P
A
N
P
P
K
Site 31
S427
V
P
A
N
P
P
K
S
P
A
P
A
A
A
A
Site 32
T441
A
P
A
V
Q
P
L
T
Q
V
G
I
T
L
L
Site 33
T480
S
V
P
T
A
A
R
T
Q
G
V
P
A
V
L
Site 34
T496
V
T
G
P
Q
A
T
T
G
T
P
L
V
T
M
Site 35
T498
G
P
Q
A
T
T
G
T
P
L
V
T
M
R
P
Site 36
T502
T
T
G
T
P
L
V
T
M
R
P
A
S
Q
A
Site 37
S507
L
V
T
M
R
P
A
S
Q
A
G
K
A
P
V
Site 38
T535
P
T
Q
S
A
Q
G
T
V
I
G
S
S
P
Q
Site 39
S539
A
Q
G
T
V
I
G
S
S
P
Q
M
S
G
M
Site 40
S540
Q
G
T
V
I
G
S
S
P
Q
M
S
G
M
A
Site 41
S562
A
T
Q
K
I
P
P
S
S
A
P
T
V
L
S
Site 42
S563
T
Q
K
I
P
P
S
S
A
P
T
V
L
S
V
Site 43
T583
I
V
K
T
M
A
V
T
P
G
T
T
T
L
P
Site 44
S597
P
A
T
V
K
V
A
S
S
P
V
M
V
S
N
Site 45
S598
A
T
V
K
V
A
S
S
P
V
M
V
S
N
P
Site 46
T607
V
M
V
S
N
P
A
T
R
M
L
K
T
A
A
Site 47
S622
A
Q
V
G
T
S
V
S
S
A
T
N
T
S
T
Site 48
T627
S
V
S
S
A
T
N
T
S
T
R
P
I
I
T
Site 49
T634
T
S
T
R
P
I
I
T
V
H
K
S
G
T
V
Site 50
T642
V
H
K
S
G
T
V
T
V
A
Q
Q
A
Q
V
Site 51
T662
G
G
V
T
K
T
I
T
L
V
K
S
P
I
S
Site 52
S666
K
T
I
T
L
V
K
S
P
I
S
V
P
G
G
Site 53
S669
T
L
V
K
S
P
I
S
V
P
G
G
S
A
L
Site 54
S674
P
I
S
V
P
G
G
S
A
L
I
S
N
L
G
Site 55
T689
K
V
M
S
V
V
Q
T
K
P
V
Q
T
S
A
Site 56
T720
K
G
P
L
P
A
G
T
I
L
K
L
V
T
S
Site 57
S727
T
I
L
K
L
V
T
S
A
D
G
K
P
T
T
Site 58
T734
S
A
D
G
K
P
T
T
I
I
T
T
T
Q
A
Site 59
T737
G
K
P
T
T
I
I
T
T
T
Q
A
S
G
A
Site 60
S755
P
T
I
L
G
I
S
S
V
S
P
S
T
T
K
Site 61
S759
G
I
S
S
V
S
P
S
T
T
K
P
G
T
T
Site 62
T760
I
S
S
V
S
P
S
T
T
K
P
G
T
T
T
Site 63
T761
S
S
V
S
P
S
T
T
K
P
G
T
T
T
I
Site 64
T766
S
T
T
K
P
G
T
T
T
I
I
K
T
I
P
Site 65
T771
G
T
T
T
I
I
K
T
I
P
M
S
A
I
I
Site 66
S788
A
G
A
T
G
V
T
S
S
P
G
I
K
S
P
Site 67
S789
G
A
T
G
V
T
S
S
P
G
I
K
S
P
I
Site 68
S794
T
S
S
P
G
I
K
S
P
I
T
I
I
T
T
Site 69
T797
P
G
I
K
S
P
I
T
I
I
T
T
K
V
M
Site 70
S806
I
T
T
K
V
M
T
S
G
T
G
A
P
A
K
Site 71
T848
Q
P
G
T
I
L
R
T
V
P
M
G
G
V
R
Site 72
S905
G
G
H
S
T
S
A
S
L
A
T
P
I
T
T
Site 73
T950
G
L
T
T
P
T
I
T
M
Q
P
V
S
Q
P
Site 74
S955
T
I
T
M
Q
P
V
S
Q
P
T
Q
V
T
L
Site 75
T987
S
I
L
A
S
P
T
T
E
Q
P
T
A
T
V
Site 76
T993
T
T
E
Q
P
T
A
T
V
T
I
A
D
S
G
Site 77
T995
E
Q
P
T
A
T
V
T
I
A
D
S
G
Q
G
Site 78
T1008
Q
G
D
V
Q
P
G
T
V
T
L
V
C
S
N
Site 79
T1010
D
V
Q
P
G
T
V
T
L
V
C
S
N
P
P
Site 80
T1023
P
P
C
E
T
H
E
T
G
T
T
N
T
A
T
Site 81
T1026
E
T
H
E
T
G
T
T
N
T
A
T
T
T
V
Site 82
T1044
L
G
G
H
P
Q
P
T
Q
V
Q
F
V
C
D
Site 83
S1058
D
R
Q
E
A
A
A
S
L
V
T
S
T
V
G
Site 84
S1070
T
V
G
Q
Q
N
G
S
V
V
R
V
C
S
N
Site 85
S1076
G
S
V
V
R
V
C
S
N
P
P
C
E
T
H
Site 86
T1088
E
T
H
E
T
G
T
T
N
T
A
T
T
A
T
Site 87
T1092
T
G
T
T
N
T
A
T
T
A
T
S
N
M
A
Site 88
S1096
N
T
A
T
T
A
T
S
N
M
A
G
Q
H
G
Site 89
T1117
E
T
H
E
T
G
T
T
N
T
A
T
T
A
M
Site 90
T1121
T
G
T
T
N
T
A
T
T
A
M
S
S
V
G
Site 91
T1143
R
R
A
C
A
A
G
T
P
A
V
I
R
I
S
Site 92
S1150
T
P
A
V
I
R
I
S
V
A
T
G
A
L
E
Site 93
S1164
E
A
A
Q
G
S
K
S
Q
C
Q
T
R
Q
T
Site 94
T1168
G
S
K
S
Q
C
Q
T
R
Q
T
S
A
T
S
Site 95
T1171
S
Q
C
Q
T
R
Q
T
S
A
T
S
T
T
M
Site 96
S1172
Q
C
Q
T
R
Q
T
S
A
T
S
T
T
M
T
Site 97
T1174
Q
T
R
Q
T
S
A
T
S
T
T
M
T
V
M
Site 98
T1176
R
Q
T
S
A
T
S
T
T
M
T
V
M
A
T
Site 99
S1188
M
A
T
G
A
P
C
S
A
G
P
L
L
G
P
Site 100
S1196
A
G
P
L
L
G
P
S
M
A
R
E
P
G
G
Site 101
S1205
A
R
E
P
G
G
R
S
P
A
F
V
Q
L
A
Site 102
S1216
V
Q
L
A
P
L
S
S
K
V
R
L
S
S
P
Site 103
S1221
L
S
S
K
V
R
L
S
S
P
S
I
K
D
L
Site 104
S1222
S
S
K
V
R
L
S
S
P
S
I
K
D
L
P
Site 105
S1224
K
V
R
L
S
S
P
S
I
K
D
L
P
A
G
Site 106
S1234
D
L
P
A
G
R
H
S
H
A
V
S
T
A
A
Site 107
S1238
G
R
H
S
H
A
V
S
T
A
A
M
T
R
S
Site 108
S1245
S
T
A
A
M
T
R
S
S
V
G
A
G
E
P
Site 109
S1246
T
A
A
M
T
R
S
S
V
G
A
G
E
P
R
Site 110
S1260
R
M
A
P
V
C
E
S
L
Q
G
G
S
P
S
Site 111
S1265
C
E
S
L
Q
G
G
S
P
S
T
T
V
T
V
Site 112
S1267
S
L
Q
G
G
S
P
S
T
T
V
T
V
T
A
Site 113
T1269
Q
G
G
S
P
S
T
T
V
T
V
T
A
L
E
Site 114
T1302
E
T
H
E
T
G
T
T
N
T
A
T
T
S
N
Site 115
T1306
T
G
T
T
N
T
A
T
T
S
N
A
G
S
A
Site 116
S1308
T
T
N
T
A
T
T
S
N
A
G
S
A
Q
R
Site 117
S1312
A
T
T
S
N
A
G
S
A
Q
R
V
C
S
N
Site 118
S1318
G
S
A
Q
R
V
C
S
N
P
P
C
E
T
H
Site 119
T1327
P
P
C
E
T
H
E
T
G
T
T
H
T
A
T
Site 120
T1330
E
T
H
E
T
G
T
T
H
T
A
T
T
A
T
Site 121
T1334
T
G
T
T
H
T
A
T
T
A
T
S
N
G
G
Site 122
T1342
T
A
T
S
N
G
G
T
G
Q
P
E
G
G
Q
Site 123
T1362
R
P
C
E
T
H
Q
T
T
S
T
G
T
T
M
Site 124
T1368
Q
T
T
S
T
G
T
T
M
S
V
S
V
G
A
Site 125
T1381
G
A
L
L
P
D
A
T
S
S
H
R
T
V
E
Site 126
S1382
A
L
L
P
D
A
T
S
S
H
R
T
V
E
S
Site 127
S1383
L
L
P
D
A
T
S
S
H
R
T
V
E
S
G
Site 128
T1386
D
A
T
S
S
H
R
T
V
E
S
G
L
E
V
Site 129
T1430
E
T
H
E
T
G
T
T
H
T
A
T
T
V
T
Site 130
T1434
T
G
T
T
H
T
A
T
T
V
T
S
N
M
S
Site 131
T1435
G
T
T
H
T
A
T
T
V
T
S
N
M
S
S
Site 132
T1437
T
H
T
A
T
T
V
T
S
N
M
S
S
N
Q
Site 133
S1442
T
V
T
S
N
M
S
S
N
Q
D
P
P
P
A
Site 134
S1451
Q
D
P
P
P
A
A
S
D
Q
G
E
V
E
S
Site 135
S1458
S
D
Q
G
E
V
E
S
T
Q
G
D
S
V
N
Site 136
T1459
D
Q
G
E
V
E
S
T
Q
G
D
S
V
N
I
Site 137
S1463
V
E
S
T
Q
G
D
S
V
N
I
T
S
S
S
Site 138
T1467
Q
G
D
S
V
N
I
T
S
S
S
A
I
T
T
Site 139
T1475
S
S
S
A
I
T
T
T
V
S
S
T
L
T
R
Site 140
T1485
S
T
L
T
R
A
V
T
T
V
T
Q
S
T
P
Site 141
S1490
A
V
T
T
V
T
Q
S
T
P
V
P
G
P
S
Site 142
T1491
V
T
T
V
T
Q
S
T
P
V
P
G
P
S
V
Site 143
S1497
S
T
P
V
P
G
P
S
V
P
P
P
E
E
L
Site 144
S1507
P
P
E
E
L
Q
V
S
P
G
P
R
Q
Q
L
Site 145
S1522
P
P
R
Q
L
L
Q
S
A
S
T
A
L
M
G
Site 146
S1524
R
Q
L
L
Q
S
A
S
T
A
L
M
G
E
S
Site 147
S1536
G
E
S
A
E
V
L
S
A
S
Q
T
P
E
L
Site 148
S1538
S
A
E
V
L
S
A
S
Q
T
P
E
L
P
A
Site 149
S1550
L
P
A
A
V
D
L
S
S
T
G
E
P
S
S
Site 150
S1551
P
A
A
V
D
L
S
S
T
G
E
P
S
S
G
Site 151
T1552
A
A
V
D
L
S
S
T
G
E
P
S
S
G
Q
Site 152
S1556
L
S
S
T
G
E
P
S
S
G
Q
E
S
A
G
Site 153
S1557
S
S
T
G
E
P
S
S
G
Q
E
S
A
G
S
Site 154
S1561
E
P
S
S
G
Q
E
S
A
G
S
A
V
V
A
Site 155
S1580
Q
P
P
P
P
T
Q
S
E
V
D
Q
L
S
L
Site 156
S1586
Q
S
E
V
D
Q
L
S
L
P
Q
E
L
M
A
Site 157
T1655
G
T
G
E
P
M
D
T
S
E
A
A
A
T
V
Site 158
S1656
T
G
E
P
M
D
T
S
E
A
A
A
T
V
T
Site 159
T1661
D
T
S
E
A
A
A
T
V
T
Q
A
E
L
G
Site 160
S1671
Q
A
E
L
G
H
L
S
A
E
G
Q
E
G
Q
Site 161
T1680
E
G
Q
E
G
Q
A
T
T
I
P
I
V
L
T
Site 162
S1722
E
A
L
A
P
A
D
S
L
N
D
P
A
I
E
Site 163
T1752
A
L
L
P
S
T
A
T
E
S
L
A
P
S
N
Site 164
S1754
L
P
S
T
A
T
E
S
L
A
P
S
N
T
F
Site 165
S1758
A
T
E
S
L
A
P
S
N
T
F
V
A
P
Q
Site 166
T1760
E
S
L
A
P
S
N
T
F
V
A
P
Q
P
V
Site 167
S1790
E
V
A
N
G
I
E
S
L
G
V
K
P
D
L
Site 168
S1802
P
D
L
P
P
P
P
S
K
A
P
M
K
K
E
Site 169
T1826
K
G
T
N
V
M
V
T
H
Y
F
L
P
P
D
Site 170
Y1828
T
N
V
M
V
T
H
Y
F
L
P
P
D
D
A
Site 171
S1838
P
P
D
D
A
V
P
S
D
D
D
L
G
T
V
Site 172
T1844
P
S
D
D
D
L
G
T
V
P
D
Y
N
Q
L
Site 173
Y1848
D
L
G
T
V
P
D
Y
N
Q
L
K
K
Q
E
Site 174
Y1862
E
L
Q
P
G
T
A
Y
K
F
R
V
A
G
I
Site 175
S1878
A
C
G
R
G
P
F
S
E
I
S
A
F
K
T
Site 176
S1881
R
G
P
F
S
E
I
S
A
F
K
T
C
L
P
Site 177
S1902
C
A
I
K
I
S
K
S
P
D
G
A
H
L
T
Site 178
T1909
S
P
D
G
A
H
L
T
W
E
P
P
S
V
T
Site 179
S1914
H
L
T
W
E
P
P
S
V
T
S
G
K
I
I
Site 180
Y1923
T
S
G
K
I
I
E
Y
S
V
Y
L
A
I
Q
Site 181
S1932
V
Y
L
A
I
Q
S
S
Q
A
G
G
E
L
K
Site 182
S1940
Q
A
G
G
E
L
K
S
S
T
P
A
Q
L
A
Site 183
S1941
A
G
G
E
L
K
S
S
T
P
A
Q
L
A
F
Site 184
T1942
G
G
E
L
K
S
S
T
P
A
Q
L
A
F
M
Site 185
S1963
S
P
S
C
L
V
Q
S
S
S
L
S
N
A
H
Site 186
S1965
S
C
L
V
Q
S
S
S
L
S
N
A
H
I
D
Site 187
S1967
L
V
Q
S
S
S
L
S
N
A
H
I
D
Y
T
Site 188
T1974
S
N
A
H
I
D
Y
T
T
K
P
A
I
I
F
Site 189
Y1991
A
A
R
N
E
K
G
Y
G
P
A
T
Q
V
R
Site 190
T1995
E
K
G
Y
G
P
A
T
Q
V
R
W
L
Q
E
Site 191
T2003
Q
V
R
W
L
Q
E
T
S
K
D
S
S
G
T
Site 192
S2004
V
R
W
L
Q
E
T
S
K
D
S
S
G
T
K
Site 193
S2008
Q
E
T
S
K
D
S
S
G
T
K
P
A
N
K
Site 194
S2019
P
A
N
K
R
P
M
S
S
P
E
M
K
S
A
Site 195
S2020
A
N
K
R
P
M
S
S
P
E
M
K
S
A
P
Site 196
S2025
M
S
S
P
E
M
K
S
A
P
K
K
S
K
A
Site 197
S2030
M
K
S
A
P
K
K
S
K
A
D
G
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation