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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRAK1
Full Name:
Interleukin-1 receptor-associated kinase 1
Alias:
EC 2.7.11.1; IL1RAK; IRAK; IRAK-1; Kinase IRAK1; MPLK; Pelle; Pelle-like protein kinase
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family
Mass (Da):
76537
Number AA:
712
UniProt ID:
P51617
International Prot ID:
IPI00293652
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0045323
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004704
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0002755
GO:0007250
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Interleukin 1 receptor-associated kinase 1 (Pelle-like protein kinase) T387 phosphosite-specific antibody AB-PK664#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK664#IRAKSelectide - IRAK1 protein kinase substrate peptide - Powder PE-01BHQ90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BHQ90#Interleukin 1 receptor-associated kinase 1 (Pelle-like protein kinase) (V384-Y390, human) pT387 phosphopeptide - Powder PE-04AMY95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMY95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T54
A
L
I
V
R
D
Q
T
E
L
R
L
C
E
R
Site 2
S62
E
L
R
L
C
E
R
S
G
Q
R
T
A
S
V
Site 3
T66
C
E
R
S
G
Q
R
T
A
S
V
L
W
P
W
Site 4
S68
R
S
G
Q
R
T
A
S
V
L
W
P
W
I
N
Site 5
T100
L
R
A
R
D
I
I
T
A
W
H
P
P
A
P
Site 6
S110
H
P
P
A
P
L
P
S
P
G
T
T
A
P
R
Site 7
T113
A
P
L
P
S
P
G
T
T
A
P
R
P
S
S
Site 8
T114
P
L
P
S
P
G
T
T
A
P
R
P
S
S
I
Site 9
S119
G
T
T
A
P
R
P
S
S
I
P
A
P
A
E
Site 10
S120
T
T
A
P
R
P
S
S
I
P
A
P
A
E
A
Site 11
S131
P
A
E
A
E
A
W
S
P
R
K
L
P
S
S
Site 12
S137
W
S
P
R
K
L
P
S
S
A
S
T
F
L
S
Site 13
S138
S
P
R
K
L
P
S
S
A
S
T
F
L
S
P
Site 14
S140
R
K
L
P
S
S
A
S
T
F
L
S
P
A
F
Site 15
S144
S
S
A
S
T
F
L
S
P
A
F
P
G
S
Q
Site 16
S150
L
S
P
A
F
P
G
S
Q
T
H
S
G
P
E
Site 17
S154
F
P
G
S
Q
T
H
S
G
P
E
L
G
L
V
Site 18
S166
G
L
V
P
S
P
A
S
L
W
P
P
P
P
S
Site 19
S173
S
L
W
P
P
P
P
S
P
A
P
S
S
T
K
Site 20
S177
P
P
P
S
P
A
P
S
S
T
K
P
G
P
E
Site 21
S178
P
P
S
P
A
P
S
S
T
K
P
G
P
E
S
Site 22
T179
P
S
P
A
P
S
S
T
K
P
G
P
E
S
S
Site 23
S185
S
T
K
P
G
P
E
S
S
V
S
L
L
Q
G
Site 24
S186
T
K
P
G
P
E
S
S
V
S
L
L
Q
G
A
Site 25
S188
P
G
P
E
S
S
V
S
L
L
Q
G
A
R
P
Site 26
T209
L
C
E
I
S
R
G
T
H
N
F
S
E
E
L
Site 27
Y227
E
G
G
F
G
C
V
Y
R
A
V
M
R
N
T
Site 28
T234
Y
R
A
V
M
R
N
T
V
Y
A
V
K
R
L
Site 29
Y236
A
V
M
R
N
T
V
Y
A
V
K
R
L
K
E
Site 30
S255
E
W
T
A
V
K
Q
S
F
L
T
E
V
E
Q
Site 31
T258
A
V
K
Q
S
F
L
T
E
V
E
Q
L
S
R
Site 32
S264
L
T
E
V
E
Q
L
S
R
F
R
H
P
N
I
Site 33
S295
Y
G
F
L
P
N
G
S
L
E
D
R
L
H
C
Site 34
T304
E
D
R
L
H
C
Q
T
Q
A
C
P
P
L
S
Site 35
S311
T
Q
A
C
P
P
L
S
W
P
Q
R
L
D
I
Site 36
S333
I
Q
F
L
H
Q
D
S
P
S
L
I
H
G
D
Site 37
S335
F
L
H
Q
D
S
P
S
L
I
H
G
D
I
K
Site 38
S343
L
I
H
G
D
I
K
S
S
N
V
L
L
D
E
Site 39
T353
V
L
L
D
E
R
L
T
P
K
L
G
D
F
G
Site 40
S365
D
F
G
L
A
R
F
S
R
F
A
G
S
S
P
Site 41
S370
R
F
S
R
F
A
G
S
S
P
S
Q
S
S
M
Site 42
S371
F
S
R
F
A
G
S
S
P
S
Q
S
S
M
V
Site 43
S373
R
F
A
G
S
S
P
S
Q
S
S
M
V
A
R
Site 44
S375
A
G
S
S
P
S
Q
S
S
M
V
A
R
T
Q
Site 45
S376
G
S
S
P
S
Q
S
S
M
V
A
R
T
Q
T
Site 46
T383
S
M
V
A
R
T
Q
T
V
R
G
T
L
A
Y
Site 47
T387
R
T
Q
T
V
R
G
T
L
A
Y
L
P
E
E
Interleukin 1 receptor-associated kinase 1 (Pelle-like protein kinase) T387 phosphosite-specific antibody AB-PK664#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK664#Interleukin 1 receptor-associated kinase 1 (Pelle-like protein kinase) (V384-Y390, human) pT387 phosphopeptide - Powder PE-04AMY95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMY95
Site 48
Y390
T
V
R
G
T
L
A
Y
L
P
E
E
Y
I
K
Site 49
Y395
L
A
Y
L
P
E
E
Y
I
K
T
G
R
L
A
Site 50
T398
L
P
E
E
Y
I
K
T
G
R
L
A
V
D
T
Site 51
T426
A
G
Q
R
A
V
K
T
H
G
A
R
T
K
Y
Site 52
Y433
T
H
G
A
R
T
K
Y
L
K
D
L
V
E
E
Site 53
S451
E
A
G
V
A
L
R
S
T
Q
S
T
L
Q
A
Site 54
T452
A
G
V
A
L
R
S
T
Q
S
T
L
Q
A
G
Site 55
T512
A
K
R
R
P
P
M
T
Q
V
Y
E
R
L
E
Site 56
Y515
R
P
P
M
T
Q
V
Y
E
R
L
E
K
L
Q
Site 57
S536
P
G
H
S
E
A
A
S
C
I
P
P
S
P
Q
Site 58
S541
A
A
S
C
I
P
P
S
P
Q
E
N
S
Y
V
Site 59
S546
P
P
S
P
Q
E
N
S
Y
V
S
S
T
G
R
Site 60
Y547
P
S
P
Q
E
N
S
Y
V
S
S
T
G
R
A
Site 61
S549
P
Q
E
N
S
Y
V
S
S
T
G
R
A
H
S
Site 62
S550
Q
E
N
S
Y
V
S
S
T
G
R
A
H
S
G
Site 63
T551
E
N
S
Y
V
S
S
T
G
R
A
H
S
G
A
Site 64
S556
S
S
T
G
R
A
H
S
G
A
A
P
W
Q
P
Site 65
S568
W
Q
P
L
A
A
P
S
G
A
S
A
Q
A
A
Site 66
S588
G
P
N
Q
P
V
E
S
D
E
S
L
G
G
L
Site 67
S591
Q
P
V
E
S
D
E
S
L
G
G
L
S
A
A
Site 68
S596
D
E
S
L
G
G
L
S
A
A
L
R
S
W
H
Site 69
S601
G
L
S
A
A
L
R
S
W
H
L
T
P
S
C
Site 70
T605
A
L
R
S
W
H
L
T
P
S
C
P
L
D
P
Site 71
S607
R
S
W
H
L
T
P
S
C
P
L
D
P
A
P
Site 72
T625
A
G
C
P
Q
G
D
T
A
G
E
S
S
W
G
Site 73
S629
Q
G
D
T
A
G
E
S
S
W
G
S
G
P
G
Site 74
S630
G
D
T
A
G
E
S
S
W
G
S
G
P
G
S
Site 75
S633
A
G
E
S
S
W
G
S
G
P
G
S
R
P
T
Site 76
S637
S
W
G
S
G
P
G
S
R
P
T
A
V
E
G
Site 77
T640
S
G
P
G
S
R
P
T
A
V
E
G
L
A
L
Site 78
S649
V
E
G
L
A
L
G
S
S
A
S
S
S
S
E
Site 79
S650
E
G
L
A
L
G
S
S
A
S
S
S
S
E
P
Site 80
S652
L
A
L
G
S
S
A
S
S
S
S
E
P
P
Q
Site 81
S653
A
L
G
S
S
A
S
S
S
S
E
P
P
Q
I
Site 82
S654
L
G
S
S
A
S
S
S
S
E
P
P
Q
I
I
Site 83
S655
G
S
S
A
S
S
S
S
E
P
P
Q
I
I
I
Site 84
Y676
M
V
Q
K
L
A
L
Y
E
D
G
A
L
D
S
Site 85
S683
Y
E
D
G
A
L
D
S
L
Q
L
L
S
S
S
Site 86
S707
D
R
Q
G
P
E
E
S
D
E
F
Q
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation