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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPC3
Full Name:
Glypican-3
Alias:
GTR2-2;Intestinal protein OCI-5;MXR7
Type:
Mass (Da):
65563
Number AA:
580
UniProt ID:
P51654
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
P
P
P
P
P
D
A
T
C
H
Q
V
R
S
F
Site 2
T55
G
L
K
W
V
P
E
T
P
V
P
G
S
D
L
Site 3
S60
P
E
T
P
V
P
G
S
D
L
Q
V
C
L
P
Site 4
T71
V
C
L
P
K
G
P
T
C
C
S
R
K
M
E
Site 5
S74
P
K
G
P
T
C
C
S
R
K
M
E
E
K
Y
Site 6
Y81
S
R
K
M
E
E
K
Y
Q
L
T
A
R
L
N
Site 7
S95
N
M
E
Q
L
L
Q
S
A
S
M
E
L
K
F
Site 8
Y125
V
V
R
H
A
K
N
Y
T
N
A
M
F
K
N
Site 9
Y134
N
A
M
F
K
N
N
Y
P
S
L
T
P
Q
A
Site 10
S136
M
F
K
N
N
Y
P
S
L
T
P
Q
A
F
E
Site 11
T138
K
N
N
Y
P
S
L
T
P
Q
A
F
E
F
V
Site 12
S190
M
N
P
G
L
P
D
S
A
L
D
I
N
E
C
Site 13
T217
N
F
P
K
L
I
M
T
Q
V
S
K
S
L
Q
Site 14
Y295
G
V
V
E
I
D
K
Y
W
R
E
Y
I
L
S
Site 15
Y299
I
D
K
Y
W
R
E
Y
I
L
S
L
E
E
L
Site 16
S302
Y
W
R
E
Y
I
L
S
L
E
E
L
V
N
G
Site 17
Y311
E
E
L
V
N
G
M
Y
R
I
Y
D
M
E
N
Site 18
Y333
T
I
H
D
S
I
Q
Y
V
Q
K
N
A
G
K
Site 19
S352
I
G
K
L
C
A
H
S
Q
Q
R
Q
Y
R
S
Site 20
Y357
A
H
S
Q
Q
R
Q
Y
R
S
A
Y
Y
P
E
Site 21
Y361
Q
R
Q
Y
R
S
A
Y
Y
P
E
D
L
F
I
Site 22
Y362
R
Q
Y
R
S
A
Y
Y
P
E
D
L
F
I
D
Site 23
T383
A
H
V
E
H
E
E
T
L
S
S
R
R
R
E
Site 24
S385
V
E
H
E
E
T
L
S
S
R
R
R
E
L
I
Site 25
S386
E
H
E
E
T
L
S
S
R
R
R
E
L
I
Q
Site 26
S400
Q
K
L
K
S
F
I
S
F
Y
S
A
L
P
G
Site 27
S411
A
L
P
G
Y
I
C
S
H
S
P
V
A
E
N
Site 28
S413
P
G
Y
I
C
S
H
S
P
V
A
E
N
D
T
Site 29
T420
S
P
V
A
E
N
D
T
L
C
W
N
G
Q
E
Site 30
S433
Q
E
L
V
E
R
Y
S
Q
K
A
A
R
N
G
Site 31
S460
K
G
P
E
P
V
V
S
Q
I
I
D
K
L
K
Site 32
S477
N
Q
L
L
R
T
M
S
M
P
K
G
R
V
L
Site 33
S495
L
D
E
E
G
F
E
S
G
D
C
G
D
D
E
Site 34
S539
V
D
D
A
P
G
N
S
Q
Q
A
T
P
K
D
Site 35
T543
P
G
N
S
Q
Q
A
T
P
K
D
N
E
I
S
Site 36
T551
P
K
D
N
E
I
S
T
F
H
N
L
G
N
V
Site 37
S560
H
N
L
G
N
V
H
S
P
L
K
L
L
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation