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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SGSH
Full Name:
N-sulphoglucosamine sulphohydrolase
Alias:
EC 3.10.1.1; HSS; MPS3A; N-sulfoglucosamine sulfohydrolase; SFMD; SPHM; Sulfamidase; Sulfoglucosamine sulfamidase; Sulphamidase
Type:
Hydrolase; EC 3.10.1.1; Glycan Metabolism - glycosaminoglycan degradation
Mass (Da):
56695
Number AA:
502
UniProt ID:
P51688
International Prot ID:
IPI00019988
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0016250
GO:0005509
GO:0008484
PhosphoSite+
KinaseNET
Biological Process:
GO:0006029
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
A
D
D
G
G
F
E
S
G
A
Y
N
N
S
A
Site 2
Y40
G
G
F
E
S
G
A
Y
N
N
S
A
I
A
T
Site 3
S43
E
S
G
A
Y
N
N
S
A
I
A
T
P
H
L
Site 4
T47
Y
N
N
S
A
I
A
T
P
H
L
D
A
L
A
Site 5
S66
L
F
R
N
A
F
T
S
V
S
S
C
S
P
S
Site 6
S68
R
N
A
F
T
S
V
S
S
C
S
P
S
R
A
Site 7
S69
N
A
F
T
S
V
S
S
C
S
P
S
R
A
S
Site 8
S73
S
V
S
S
C
S
P
S
R
A
S
L
L
T
G
Site 9
S76
S
C
S
P
S
R
A
S
L
L
T
G
L
P
Q
Site 10
T79
P
S
R
A
S
L
L
T
G
L
P
Q
H
Q
N
Site 11
S100
Q
D
V
H
H
F
N
S
F
D
K
V
R
S
L
Site 12
S106
N
S
F
D
K
V
R
S
L
P
L
L
L
S
Q
Site 13
T130
K
K
H
V
G
P
E
T
V
Y
P
F
D
F
A
Site 14
Y132
H
V
G
P
E
T
V
Y
P
F
D
F
A
Y
T
Site 15
Y138
V
Y
P
F
D
F
A
Y
T
E
E
N
G
S
V
Site 16
S144
A
Y
T
E
E
N
G
S
V
L
Q
V
G
R
N
Site 17
T165
L
V
R
K
F
L
Q
T
Q
D
D
R
P
F
F
Site 18
Y174
D
D
R
P
F
F
L
Y
V
A
F
H
D
P
H
Site 19
Y190
C
G
H
S
Q
P
Q
Y
G
T
F
C
E
K
F
Site 20
S202
E
K
F
G
N
G
E
S
G
M
G
R
I
P
D
Site 21
T211
M
G
R
I
P
D
W
T
P
Q
A
Y
D
P
L
Site 22
Y240
R
A
D
L
A
A
Q
Y
T
T
V
G
R
M
D
Site 23
Y286
P
S
G
R
T
N
L
Y
W
P
G
T
A
E
P
Site 24
S298
A
E
P
L
L
V
S
S
P
E
H
P
K
R
W
Site 25
S309
P
K
R
W
G
Q
V
S
E
A
Y
V
S
L
L
Site 26
T344
G
S
K
T
I
H
L
T
G
R
S
L
L
P
A
Site 27
T360
E
A
E
P
L
W
A
T
V
F
G
S
Q
S
H
Site 28
S364
L
W
A
T
V
F
G
S
Q
S
H
H
E
V
T
Site 29
S366
A
T
V
F
G
S
Q
S
H
H
E
V
T
M
S
Site 30
S373
S
H
H
E
V
T
M
S
Y
P
M
R
S
V
Q
Site 31
Y403
F
P
I
D
Q
D
F
Y
V
S
P
T
F
Q
D
Site 32
S405
I
D
Q
D
F
Y
V
S
P
T
F
Q
D
L
L
Site 33
T407
Q
D
F
Y
V
S
P
T
F
Q
D
L
L
N
R
Site 34
T416
Q
D
L
L
N
R
T
T
A
G
Q
P
T
G
W
Site 35
Y424
A
G
Q
P
T
G
W
Y
K
D
L
R
H
Y
Y
Site 36
Y431
Y
K
D
L
R
H
Y
Y
Y
R
A
R
W
E
L
Site 37
Y432
K
D
L
R
H
Y
Y
Y
R
A
R
W
E
L
Y
Site 38
Y439
Y
R
A
R
W
E
L
Y
D
R
S
R
D
P
H
Site 39
S442
R
W
E
L
Y
D
R
S
R
D
P
H
E
T
Q
Site 40
T448
R
S
R
D
P
H
E
T
Q
N
L
A
T
D
P
Site 41
S492
G
V
L
E
E
K
L
S
P
Q
C
Q
P
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation