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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP11
Full Name:
Ubiquitin carboxyl-terminal hydrolase 11
Alias:
Deubiquitinating enzyme 11; Ubiquitin carboxyl-terminal hydrolase, X-linked; Ubiquitin specific peptidase 11; Ubiquitin specific protease 11; Ubiquitin thioesterase 11; Ubiquitin thiolesterase 11; Ubiquitin-specific processing protease 11; UBP11; UHX1
Type:
Nucleus protein; Ubiquitin conjugating system, Protease
Mass (Da):
109817
Number AA:
963
UniProt ID:
P51784
International Prot ID:
IPI00184533
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
V
E
G
R
L
P
I
S
H
S
C
V
G
C
R
Site 2
S33
G
R
L
P
I
S
H
S
C
V
G
C
R
R
E
Site 3
T46
R
E
R
T
A
M
A
T
V
A
A
N
P
A
A
Site 4
S80
E
E
L
P
G
L
D
S
Q
W
R
Q
I
E
N
Site 5
S90
R
Q
I
E
N
G
E
S
G
R
E
R
P
L
R
Site 6
S124
V
Q
G
G
D
Q
D
S
S
T
F
P
G
C
I
Site 7
S125
Q
G
G
D
Q
D
S
S
T
F
P
G
C
I
N
Site 8
T126
G
G
D
Q
D
S
S
T
F
P
G
C
I
N
N
Site 9
Y195
N
I
Q
K
V
E
V
Y
P
V
E
L
L
L
V
Site 10
S210
R
H
N
D
L
G
K
S
H
T
V
Q
F
S
H
Site 11
T212
N
D
L
G
K
S
H
T
V
Q
F
S
H
T
D
Site 12
S216
K
S
H
T
V
Q
F
S
H
T
D
S
I
G
L
Site 13
S247
T
R
L
W
A
K
N
S
E
G
S
L
D
R
L
Site 14
S250
W
A
K
N
S
E
G
S
L
D
R
L
Y
D
T
Site 15
Y255
E
G
S
L
D
R
L
Y
D
T
H
I
T
V
L
Site 16
T257
S
L
D
R
L
Y
D
T
H
I
T
V
L
D
A
Site 17
T282
E
T
R
K
K
D
G
T
W
P
S
A
Q
L
H
Site 18
S328
N
S
A
L
Q
C
L
S
N
V
P
Q
L
T
E
Site 19
T334
L
S
N
V
P
Q
L
T
E
Y
F
L
N
N
C
Site 20
Y336
N
V
P
Q
L
T
E
Y
F
L
N
N
C
Y
L
Site 21
Y342
E
Y
F
L
N
N
C
Y
L
E
E
L
N
F
R
Site 22
Y362
K
G
E
I
A
E
A
Y
A
D
L
V
K
Q
A
Site 23
Y396
F
A
S
Q
F
L
G
Y
Q
Q
H
D
S
Q
E
Site 24
S401
L
G
Y
Q
Q
H
D
S
Q
E
L
L
S
F
L
Site 25
S406
H
D
S
Q
E
L
L
S
F
L
L
D
G
L
H
Site 26
Y424
N
R
V
K
K
K
E
Y
V
E
L
C
D
A
A
Site 27
S452
N
H
K
R
R
N
D
S
V
I
V
D
T
F
H
Site 28
T457
N
D
S
V
I
V
D
T
F
H
G
L
F
K
S
Site 29
S523
V
P
K
K
G
K
I
S
D
L
C
V
A
L
S
Site 30
S536
L
S
K
H
T
G
I
S
P
E
R
M
M
V
A
Site 31
S547
M
M
V
A
D
V
F
S
H
R
F
Y
K
L
Y
Site 32
Y551
D
V
F
S
H
R
F
Y
K
L
Y
Q
L
E
E
Site 33
Y554
S
H
R
F
Y
K
L
Y
Q
L
E
E
P
L
S
Site 34
S561
Y
Q
L
E
E
P
L
S
S
I
L
D
R
D
D
Site 35
S562
Q
L
E
E
P
L
S
S
I
L
D
R
D
D
I
Site 36
Y572
D
R
D
D
I
F
V
Y
E
V
S
G
R
I
E
Site 37
S584
R
I
E
A
I
E
G
S
R
E
D
I
V
V
P
Site 38
Y593
E
D
I
V
V
P
V
Y
L
R
E
R
T
P
A
Site 39
T598
P
V
Y
L
R
E
R
T
P
A
R
D
Y
N
N
Site 40
Y603
E
R
T
P
A
R
D
Y
N
N
S
Y
Y
G
L
Site 41
S606
P
A
R
D
Y
N
N
S
Y
Y
G
L
M
L
F
Site 42
Y607
A
R
D
Y
N
N
S
Y
Y
G
L
M
L
F
G
Site 43
Y608
R
D
Y
N
N
S
Y
Y
G
L
M
L
F
G
H
Site 44
S620
F
G
H
P
L
L
V
S
V
P
R
D
R
F
T
Site 45
T627
S
V
P
R
D
R
F
T
W
E
G
L
Y
N
V
Site 46
Y632
R
F
T
W
E
G
L
Y
N
V
L
M
Y
R
L
Site 47
S640
N
V
L
M
Y
R
L
S
R
Y
V
T
K
P
N
Site 48
Y642
L
M
Y
R
L
S
R
Y
V
T
K
P
N
S
D
Site 49
T644
Y
R
L
S
R
Y
V
T
K
P
N
S
D
D
E
Site 50
S648
R
Y
V
T
K
P
N
S
D
D
E
D
D
G
D
Site 51
S671
K
D
D
V
P
G
P
S
T
G
G
S
L
R
D
Site 52
T672
D
D
V
P
G
P
S
T
G
G
S
L
R
D
P
Site 53
S675
P
G
P
S
T
G
G
S
L
R
D
P
E
P
E
Site 54
S688
P
E
Q
A
G
P
S
S
G
V
T
N
R
C
P
Site 55
S705
L
D
N
C
L
G
T
S
Q
W
P
P
R
R
R
Site 56
T718
R
R
R
K
Q
L
F
T
L
Q
T
V
N
S
N
Site 57
T721
K
Q
L
F
T
L
Q
T
V
N
S
N
G
T
S
Site 58
S724
F
T
L
Q
T
V
N
S
N
G
T
S
D
R
T
Site 59
S728
T
V
N
S
N
G
T
S
D
R
T
T
S
P
E
Site 60
T731
S
N
G
T
S
D
R
T
T
S
P
E
E
V
H
Site 61
T732
N
G
T
S
D
R
T
T
S
P
E
E
V
H
A
Site 62
S733
G
T
S
D
R
T
T
S
P
E
E
V
H
A
Q
Site 63
Y756
P
E
M
K
K
R
Y
Y
D
E
V
E
A
E
G
Site 64
Y764
D
E
V
E
A
E
G
Y
V
K
H
D
C
V
G
Site 65
T790
E
C
I
E
L
F
T
T
V
E
T
L
E
K
E
Site 66
Y801
L
E
K
E
N
P
W
Y
C
P
S
C
K
Q
H
Site 67
S832
I
I
H
L
K
R
F
S
Y
T
K
F
S
R
E
Site 68
Y833
I
H
L
K
R
F
S
Y
T
K
F
S
R
E
K
Site 69
S837
R
F
S
Y
T
K
F
S
R
E
K
L
D
T
L
Site 70
T843
F
S
R
E
K
L
D
T
L
V
E
F
P
I
R
Site 71
S855
P
I
R
D
L
D
F
S
E
F
V
I
Q
P
Q
Site 72
Y870
N
E
S
N
P
E
L
Y
K
Y
D
L
I
A
V
Site 73
Y872
S
N
P
E
L
Y
K
Y
D
L
I
A
V
S
N
Site 74
Y889
G
G
M
R
D
G
H
Y
T
T
F
A
C
N
K
Site 75
Y903
K
D
S
G
Q
W
H
Y
F
D
D
N
S
V
S
Site 76
S910
P
A
S
P
A
C
S
S
P
P
S
S
E
F
M
Site 77
Y923
Q
I
E
S
K
A
A
Y
V
L
F
Y
Q
R
Q
Site 78
Y927
K
A
A
Y
V
L
F
Y
Q
R
Q
D
V
A
R
Site 79
S938
D
V
A
R
R
L
L
S
P
A
G
S
S
G
A
Site 80
S942
R
L
L
S
P
A
G
S
S
G
A
P
A
S
P
Site 81
S943
L
L
S
P
A
G
S
S
G
A
P
A
S
P
A
Site 82
S948
G
S
S
G
A
P
A
S
P
A
C
S
S
P
P
Site 83
S952
A
P
A
S
P
A
C
S
S
P
P
S
S
E
F
Site 84
S953
P
A
S
P
A
C
S
S
P
P
S
S
E
F
M
Site 85
S956
P
A
C
S
S
P
P
S
S
E
F
M
D
V
N
Site 86
S957
A
C
S
S
P
P
S
S
E
F
M
D
V
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation