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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCN2
Full Name:
Chloride channel protein 2
Alias:
Chloride channel 2; CIC-2; CLC2; ClC-2; ECA3; EGI3; EGMA
Type:
Membrane, Integral membrane protein
Mass (Da):
98495
Number AA:
898
UniProt ID:
P51788
International Prot ID:
IPI00020504
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
Uniprot
OncoNet
Molecular Function:
GO:0031404
GO:0005247
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
R
A
L
Q
H
E
Q
T
L
M
Y
G
R
Y
T
Site 2
Y23
Q
H
E
Q
T
L
M
Y
G
R
Y
T
Q
D
L
Site 3
Y26
Q
T
L
M
Y
G
R
Y
T
Q
D
L
G
A
F
Site 4
T27
T
L
M
Y
G
R
Y
T
Q
D
L
G
A
F
A
Site 5
S54
E
P
W
K
G
P
P
S
S
R
A
A
P
E
L
Site 6
S55
P
W
K
G
P
P
S
S
R
A
A
P
E
L
L
Site 7
Y64
A
A
P
E
L
L
E
Y
G
R
S
R
C
A
R
Site 8
S67
E
L
L
E
Y
G
R
S
R
C
A
R
C
R
V
Site 9
S76
C
A
R
C
R
V
C
S
V
R
C
H
K
F
L
Site 10
T193
I
A
K
V
I
G
L
T
C
A
L
G
S
G
M
Site 11
Y230
L
S
L
F
G
G
I
Y
E
N
E
S
R
N
T
Site 12
S234
G
G
I
Y
E
N
E
S
R
N
T
E
M
L
A
Site 13
T237
Y
E
N
E
S
R
N
T
E
M
L
A
A
A
C
Site 14
T303
N
R
D
E
E
T
I
T
A
L
F
K
T
R
F
Site 15
T308
T
I
T
A
L
F
K
T
R
F
R
L
D
F
P
Site 16
T354
Q
V
M
R
K
Q
K
T
I
N
R
F
L
M
R
Site 17
S392
Q
F
M
A
G
Q
L
S
Q
K
E
T
L
V
T
Site 18
T396
G
Q
L
S
Q
K
E
T
L
V
T
L
F
D
N
Site 19
T399
S
Q
K
E
T
L
V
T
L
F
D
N
R
T
W
Site 20
S419
V
E
E
L
E
P
P
S
T
S
Q
A
W
N
P
Site 21
T420
E
E
L
E
P
P
S
T
S
Q
A
W
N
P
P
Site 22
S421
E
L
E
P
P
S
T
S
Q
A
W
N
P
P
R
Site 23
S489
P
D
G
I
H
T
D
S
S
T
Y
R
I
V
P
Site 24
S490
D
G
I
H
T
D
S
S
T
Y
R
I
V
P
G
Site 25
T491
G
I
H
T
D
S
S
T
Y
R
I
V
P
G
G
Site 26
S551
V
A
Q
S
L
Q
P
S
L
Y
D
S
I
I
R
Site 27
Y553
Q
S
L
Q
P
S
L
Y
D
S
I
I
R
I
K
Site 28
S555
L
Q
P
S
L
Y
D
S
I
I
R
I
K
K
L
Site 29
Y564
I
R
I
K
K
L
P
Y
L
P
E
L
G
W
G
Site 30
Y576
G
W
G
R
H
Q
Q
Y
R
V
R
V
E
D
I
Site 31
S594
D
V
P
H
V
A
L
S
C
T
F
R
D
L
R
Site 32
S641
A
L
L
G
A
Q
L
S
P
A
R
R
R
Q
H
Site 33
T655
H
M
Q
E
R
R
A
T
Q
T
S
P
L
S
D
Site 34
T657
Q
E
R
R
A
T
Q
T
S
P
L
S
D
Q
E
Site 35
S658
E
R
R
A
T
Q
T
S
P
L
S
D
Q
E
G
Site 36
S661
A
T
Q
T
S
P
L
S
D
Q
E
G
P
P
S
Site 37
S668
S
D
Q
E
G
P
P
S
P
E
A
S
V
C
F
Site 38
S672
G
P
P
S
P
E
A
S
V
C
F
Q
V
N
T
Site 39
T691
F
P
A
A
R
G
E
T
H
K
P
L
K
P
A
Site 40
S704
P
A
L
K
R
G
P
S
V
T
R
N
L
G
E
Site 41
T706
L
K
R
G
P
S
V
T
R
N
L
G
E
S
P
Site 42
S712
V
T
R
N
L
G
E
S
P
T
G
S
A
E
S
Site 43
T714
R
N
L
G
E
S
P
T
G
S
A
E
S
A
G
Site 44
S716
L
G
E
S
P
T
G
S
A
E
S
A
G
I
A
Site 45
S731
L
R
S
L
F
C
G
S
P
P
P
E
A
A
S
Site 46
S738
S
P
P
P
E
A
A
S
E
K
L
E
S
C
E
Site 47
S743
A
A
S
E
K
L
E
S
C
E
K
R
K
L
K
Site 48
S755
K
L
K
R
V
R
I
S
L
A
S
D
A
D
L
Site 49
S758
R
V
R
I
S
L
A
S
D
A
D
L
E
G
E
Site 50
S767
A
D
L
E
G
E
M
S
P
E
E
I
L
E
W
Site 51
S802
F
Q
L
V
E
R
T
S
L
H
K
T
H
T
I
Site 52
T806
E
R
T
S
L
H
K
T
H
T
I
F
S
L
L
Site 53
S811
H
K
T
H
T
I
F
S
L
L
G
V
D
H
A
Site 54
S822
V
D
H
A
Y
V
T
S
I
G
R
L
I
G
I
Site 55
S842
L
R
K
A
I
E
G
S
V
T
A
Q
G
V
K
Site 56
T844
K
A
I
E
G
S
V
T
A
Q
G
V
K
V
R
Site 57
S856
K
V
R
P
P
L
A
S
F
R
D
S
A
T
S
Site 58
S860
P
L
A
S
F
R
D
S
A
T
S
S
S
D
T
Site 59
T862
A
S
F
R
D
S
A
T
S
S
S
D
T
E
T
Site 60
S863
S
F
R
D
S
A
T
S
S
S
D
T
E
T
T
Site 61
S864
F
R
D
S
A
T
S
S
S
D
T
E
T
T
E
Site 62
S865
R
D
S
A
T
S
S
S
D
T
E
T
T
E
V
Site 63
T867
S
A
T
S
S
S
D
T
E
T
T
E
V
H
A
Site 64
T869
T
S
S
S
D
T
E
T
T
E
V
H
A
L
W
Site 65
S880
H
A
L
W
G
P
H
S
R
H
G
L
P
R
E
Site 66
S889
H
G
L
P
R
E
G
S
P
S
D
S
D
D
K
Site 67
S891
L
P
R
E
G
S
P
S
D
S
D
D
K
C
Q
Site 68
S893
R
E
G
S
P
S
D
S
D
D
K
C
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation