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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCN4
Full Name:
H(+)/Cl(-) exchange transporter 4
Alias:
Chloride channel protein 4;Chloride transporter ClC-4
Type:
Mass (Da):
84917
Number AA:
760
UniProt ID:
P51793
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
E
P
F
P
D
V
G
T
Y
E
D
F
H
T
I
Site 2
Y27
P
F
P
D
V
G
T
Y
E
D
F
H
T
I
D
Site 3
T32
G
T
Y
E
D
F
H
T
I
D
W
L
R
E
K
Site 4
S40
I
D
W
L
R
E
K
S
R
D
T
D
R
H
R
Site 5
T43
L
R
E
K
S
R
D
T
D
R
H
R
K
I
T
Site 6
T50
T
D
R
H
R
K
I
T
S
K
S
K
E
S
I
Site 7
S51
D
R
H
R
K
I
T
S
K
S
K
E
S
I
W
Site 8
S53
H
R
K
I
T
S
K
S
K
E
S
I
W
E
F
Site 9
T122
C
W
T
S
N
E
T
T
F
E
D
R
D
K
C
Site 10
S143
S
E
L
L
V
N
Q
S
E
G
A
S
A
Y
I
Site 11
S147
V
N
Q
S
E
G
A
S
A
Y
I
L
N
Y
L
Site 12
S243
N
F
F
S
S
L
F
S
K
Y
S
K
N
E
G
Site 13
Y245
F
S
S
L
F
S
K
Y
S
K
N
E
G
K
R
Site 14
S246
S
S
L
F
S
K
Y
S
K
N
E
G
K
R
R
Site 15
Y285
S
L
E
E
V
S
Y
Y
F
P
L
K
T
L
W
Site 16
Y320
N
S
R
L
V
L
F
Y
V
E
Y
H
T
P
W
Site 17
T362
A
W
C
R
R
R
K
T
T
R
L
G
K
Y
P
Site 18
T363
W
C
R
R
R
K
T
T
R
L
G
K
Y
P
V
Site 19
Y385
A
I
T
A
I
I
A
Y
P
N
P
Y
T
R
Q
Site 20
Y389
I
I
A
Y
P
N
P
Y
T
R
Q
S
T
S
E
Site 21
T390
I
A
Y
P
N
P
Y
T
R
Q
S
T
S
E
L
Site 22
S393
P
N
P
Y
T
R
Q
S
T
S
E
L
I
S
E
Site 23
T394
N
P
Y
T
R
Q
S
T
S
E
L
I
S
E
L
Site 24
S395
P
Y
T
R
Q
S
T
S
E
L
I
S
E
L
F
Site 25
S399
Q
S
T
S
E
L
I
S
E
L
F
N
D
C
G
Site 26
S411
D
C
G
A
L
E
S
S
Q
L
C
D
Y
I
N
Site 27
Y416
E
S
S
Q
L
C
D
Y
I
N
D
P
N
M
T
Site 28
Y572
A
F
G
K
E
G
I
Y
E
A
H
I
H
L
N
Site 29
Y581
A
H
I
H
L
N
G
Y
P
F
L
D
V
K
D
Site 30
T591
L
D
V
K
D
E
F
T
H
R
T
L
A
T
D
Site 31
T597
F
T
H
R
T
L
A
T
D
V
M
R
P
R
R
Site 32
S610
R
R
G
E
P
P
L
S
V
L
T
Q
D
S
M
Site 33
T624
M
T
V
E
D
V
E
T
L
I
K
E
T
D
Y
Site 34
S672
Q
E
G
I
V
S
N
S
I
M
Y
F
T
E
E
Site 35
Y675
I
V
S
N
S
I
M
Y
F
T
E
E
P
P
E
Site 36
S687
P
P
E
L
P
A
N
S
P
H
P
L
K
L
R
Site 37
S700
L
R
R
I
L
N
L
S
P
F
T
V
T
D
H
Site 38
T705
N
L
S
P
F
T
V
T
D
H
T
P
M
E
T
Site 39
T708
P
F
T
V
T
D
H
T
P
M
E
T
V
V
D
Site 40
T712
T
D
H
T
P
M
E
T
V
V
D
I
F
R
K
Site 41
T738
G
R
L
L
G
I
I
T
K
K
D
V
L
R
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation