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Updated November 2019
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Protein Info
Short Name:
AFF2
Full Name:
AF4/FMR2 family member 2
Alias:
AF4/FMR2 family, member 2; FMR2; FMR2P; Fragile X E mental retardation syndrome; FRAXE; Protein Ox19
Type:
DNA binding protein
Mass (Da):
144771
Number AA:
1311
UniProt ID:
P51816
International Prot ID:
IPI00020903
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
D
L
E
Q
Q
C
H
Y
E
Q
D
R
S
A
L
Site 2
S46
Q
E
D
D
L
F
S
S
G
F
D
L
F
G
E
Site 3
Y55
F
D
L
F
G
E
P
Y
K
V
A
E
Y
T
N
Site 4
Y60
E
P
Y
K
V
A
E
Y
T
N
K
G
D
A
L
Site 5
S89
K
N
L
L
T
N
H
S
N
Q
N
H
L
V
G
Site 6
S101
L
V
G
I
P
K
N
S
V
P
Q
N
P
N
N
Site 7
S113
P
N
N
K
N
E
P
S
F
F
P
E
Q
K
N
Site 8
T130
I
P
P
H
Q
D
N
T
H
P
S
A
P
M
P
Site 9
S133
H
Q
D
N
T
H
P
S
A
P
M
P
P
P
S
Site 10
S151
L
N
S
T
L
I
H
S
N
R
K
S
K
P
E
Site 11
S155
L
I
H
S
N
R
K
S
K
P
E
W
S
R
D
Site 12
S163
K
P
E
W
S
R
D
S
H
N
P
S
T
V
L
Site 13
S167
S
R
D
S
H
N
P
S
T
V
L
A
S
Q
A
Site 14
T168
R
D
S
H
N
P
S
T
V
L
A
S
Q
A
S
Site 15
S172
N
P
S
T
V
L
A
S
Q
A
S
G
Q
P
N
Site 16
S175
T
V
L
A
S
Q
A
S
G
Q
P
N
K
M
Q
Site 17
T185
P
N
K
M
Q
T
L
T
Q
D
Q
S
Q
A
K
Site 18
S189
Q
T
L
T
Q
D
Q
S
Q
A
K
L
E
D
F
Site 19
Y199
K
L
E
D
F
F
V
Y
P
A
E
Q
P
Q
I
Site 20
S212
Q
I
G
E
V
E
E
S
N
P
S
A
K
E
D
Site 21
S215
E
V
E
E
S
N
P
S
A
K
E
D
S
N
P
Site 22
S220
N
P
S
A
K
E
D
S
N
P
N
S
S
G
E
Site 23
S224
K
E
D
S
N
P
N
S
S
G
E
D
A
F
K
Site 24
S236
A
F
K
E
I
F
Q
S
N
S
P
E
E
S
E
Site 25
S238
K
E
I
F
Q
S
N
S
P
E
E
S
E
F
A
Site 26
S242
Q
S
N
S
P
E
E
S
E
F
A
V
Q
A
P
Site 27
S266
L
A
P
S
S
G
L
S
V
Q
N
F
P
P
G
Site 28
Y275
Q
N
F
P
P
G
L
Y
C
K
T
S
M
G
Q
Site 29
S279
P
G
L
Y
C
K
T
S
M
G
Q
Q
K
P
T
Site 30
T286
S
M
G
Q
Q
K
P
T
A
Y
V
R
P
M
D
Site 31
Y288
G
Q
Q
K
P
T
A
Y
V
R
P
M
D
G
Q
Site 32
S302
Q
D
Q
A
P
D
I
S
P
T
L
K
P
S
I
Site 33
T304
Q
A
P
D
I
S
P
T
L
K
P
S
I
E
F
Site 34
S308
I
S
P
T
L
K
P
S
I
E
F
E
N
S
F
Site 35
S314
P
S
I
E
F
E
N
S
F
G
N
L
S
F
G
Site 36
S319
E
N
S
F
G
N
L
S
F
G
T
L
L
D
G
Site 37
S329
T
L
L
D
G
K
P
S
A
A
S
S
K
T
K
Site 38
S333
G
K
P
S
A
A
S
S
K
T
K
L
P
K
F
Site 39
T345
P
K
F
T
I
L
Q
T
S
E
V
S
L
P
S
Site 40
S346
K
F
T
I
L
Q
T
S
E
V
S
L
P
S
D
Site 41
S349
I
L
Q
T
S
E
V
S
L
P
S
D
P
S
C
Site 42
S355
V
S
L
P
S
D
P
S
C
V
E
E
I
L
R
Site 43
T365
E
E
I
L
R
E
M
T
H
S
W
P
T
P
L
Site 44
S367
I
L
R
E
M
T
H
S
W
P
T
P
L
T
S
Site 45
T370
E
M
T
H
S
W
P
T
P
L
T
S
M
H
T
Site 46
S374
S
W
P
T
P
L
T
S
M
H
T
A
G
H
S
Site 47
S381
S
M
H
T
A
G
H
S
E
Q
S
T
F
S
I
Site 48
T385
A
G
H
S
E
Q
S
T
F
S
I
P
G
Q
E
Site 49
S387
H
S
E
Q
S
T
F
S
I
P
G
Q
E
S
Q
Site 50
S393
F
S
I
P
G
Q
E
S
Q
H
L
T
P
G
F
Site 51
T397
G
Q
E
S
Q
H
L
T
P
G
F
T
L
Q
K
Site 52
T409
L
Q
K
W
N
D
P
T
T
R
A
S
T
K
S
Site 53
T410
Q
K
W
N
D
P
T
T
R
A
S
T
K
S
V
Site 54
S413
N
D
P
T
T
R
A
S
T
K
S
V
S
F
K
Site 55
T414
D
P
T
T
R
A
S
T
K
S
V
S
F
K
S
Site 56
S416
T
T
R
A
S
T
K
S
V
S
F
K
S
M
L
Site 57
S418
R
A
S
T
K
S
V
S
F
K
S
M
L
E
D
Site 58
S421
T
K
S
V
S
F
K
S
M
L
E
D
D
L
K
Site 59
S430
L
E
D
D
L
K
L
S
S
D
E
D
D
L
E
Site 60
S431
E
D
D
L
K
L
S
S
D
E
D
D
L
E
P
Site 61
T441
D
D
L
E
P
V
K
T
L
T
T
Q
C
T
A
Site 62
Y452
Q
C
T
A
T
E
L
Y
Q
A
V
E
K
A
K
Site 63
T471
P
V
N
P
P
L
A
T
P
Q
P
P
P
A
V
Site 64
S481
P
P
P
A
V
Q
A
S
G
G
S
G
S
S
S
Site 65
S484
A
V
Q
A
S
G
G
S
G
S
S
S
E
S
E
Site 66
S486
Q
A
S
G
G
S
G
S
S
S
E
S
E
S
S
Site 67
S487
A
S
G
G
S
G
S
S
S
E
S
E
S
S
S
Site 68
S488
S
G
G
S
G
S
S
S
E
S
E
S
S
S
E
Site 69
S490
G
S
G
S
S
S
E
S
E
S
S
S
E
S
D
Site 70
S492
G
S
S
S
E
S
E
S
S
S
E
S
D
S
D
Site 71
S493
S
S
S
E
S
E
S
S
S
E
S
D
S
D
T
Site 72
S494
S
S
E
S
E
S
S
S
E
S
D
S
D
T
E
Site 73
S496
E
S
E
S
S
S
E
S
D
S
D
T
E
S
S
Site 74
S498
E
S
S
S
E
S
D
S
D
T
E
S
S
T
T
Site 75
T500
S
S
E
S
D
S
D
T
E
S
S
T
T
D
S
Site 76
S502
E
S
D
S
D
T
E
S
S
T
T
D
S
E
S
Site 77
S503
S
D
S
D
T
E
S
S
T
T
D
S
E
S
N
Site 78
T505
S
D
T
E
S
S
T
T
D
S
E
S
N
E
A
Site 79
S507
T
E
S
S
T
T
D
S
E
S
N
E
A
P
R
Site 80
S509
S
S
T
T
D
S
E
S
N
E
A
P
R
V
A
Site 81
T517
N
E
A
P
R
V
A
T
P
E
P
E
P
P
S
Site 82
S524
T
P
E
P
E
P
P
S
T
N
K
W
Q
L
D
Site 83
T525
P
E
P
E
P
P
S
T
N
K
W
Q
L
D
K
Site 84
S543
K
V
T
S
Q
N
K
S
F
I
C
G
Q
N
E
Site 85
S557
E
T
P
M
E
T
I
S
L
P
P
P
I
I
Q
Site 86
S577
M
K
V
K
T
N
A
S
Q
V
P
A
E
P
K
Site 87
S590
P
K
E
R
P
L
L
S
L
I
R
E
K
A
R
Site 88
T601
E
K
A
R
P
R
P
T
Q
K
I
P
E
T
K
Site 89
S615
K
A
L
K
H
K
L
S
T
T
S
E
T
V
S
Site 90
S618
K
H
K
L
S
T
T
S
E
T
V
S
Q
R
T
Site 91
T620
K
L
S
T
T
S
E
T
V
S
Q
R
T
I
G
Site 92
S622
S
T
T
S
E
T
V
S
Q
R
T
I
G
K
K
Site 93
S639
K
K
V
E
K
N
T
S
T
D
E
F
T
W
P
Site 94
S653
P
K
P
N
I
T
S
S
T
P
K
E
K
E
S
Site 95
T654
K
P
N
I
T
S
S
T
P
K
E
K
E
S
V
Site 96
Y697
L
A
P
E
K
K
K
Y
R
G
P
G
K
I
V
Site 97
S707
P
G
K
I
V
P
K
S
R
E
F
I
E
T
D
Site 98
T713
K
S
R
E
F
I
E
T
D
S
S
T
S
D
S
Site 99
S715
R
E
F
I
E
T
D
S
S
T
S
D
S
N
T
Site 100
S716
E
F
I
E
T
D
S
S
T
S
D
S
N
T
D
Site 101
S720
T
D
S
S
T
S
D
S
N
T
D
Q
E
E
T
Site 102
T722
S
S
T
S
D
S
N
T
D
Q
E
E
T
L
Q
Site 103
S746
S
G
G
N
T
A
K
S
K
E
I
C
G
A
S
Site 104
S761
L
T
L
S
T
L
M
S
S
S
G
S
N
N
N
Site 105
S763
L
S
T
L
M
S
S
S
G
S
N
N
N
L
S
Site 106
S765
T
L
M
S
S
S
G
S
N
N
N
L
S
I
S
Site 107
S770
S
G
S
N
N
N
L
S
I
S
N
E
E
P
T
Site 108
S772
S
N
N
N
L
S
I
S
N
E
E
P
T
F
S
Site 109
T777
S
I
S
N
E
E
P
T
F
S
P
I
P
V
M
Site 110
S779
S
N
E
E
P
T
F
S
P
I
P
V
M
Q
T
Site 111
S790
V
M
Q
T
E
I
L
S
P
L
R
D
H
E
N
Site 112
S811
K
I
D
L
D
L
L
S
R
V
P
G
H
S
S
Site 113
S817
L
S
R
V
P
G
H
S
S
L
H
A
A
P
A
Site 114
S818
S
R
V
P
G
H
S
S
L
H
A
A
P
A
K
Site 115
T839
A
T
K
P
K
R
Q
T
A
V
T
A
V
E
K
Site 116
T842
P
K
R
Q
T
A
V
T
A
V
E
K
P
A
P
Site 117
T895
P
P
H
K
P
P
N
T
R
E
N
N
S
S
R
Site 118
S900
P
N
T
R
E
N
N
S
S
R
R
A
N
R
R
Site 119
S901
N
T
R
E
N
N
S
S
R
R
A
N
R
R
K
Site 120
S918
K
L
F
P
P
P
L
S
P
L
P
E
D
P
P
Site 121
S931
P
P
R
R
R
N
V
S
G
N
N
G
P
F
G
Site 122
S951
A
M
T
G
Q
I
T
S
T
K
P
K
R
T
E
Site 123
T964
T
E
G
K
F
C
A
T
F
K
G
I
S
V
N
Site 124
T975
I
S
V
N
E
G
D
T
P
K
K
A
S
S
A
Site 125
T1032
T
I
T
S
T
I
T
T
G
L
M
D
S
S
H
Site 126
S1037
I
T
T
G
L
M
D
S
S
H
L
E
M
T
S
Site 127
S1038
T
T
G
L
M
D
S
S
H
L
E
M
T
S
W
Site 128
S1053
A
A
L
P
L
L
S
S
S
S
T
N
V
R
R
Site 129
S1054
A
L
P
L
L
S
S
S
S
T
N
V
R
R
P
Site 130
S1055
L
P
L
L
S
S
S
S
T
N
V
R
R
P
K
Site 131
T1056
P
L
L
S
S
S
S
T
N
V
R
R
P
K
L
Site 132
T1064
N
V
R
R
P
K
L
T
F
D
D
S
V
H
N
Site 133
S1068
P
K
L
T
F
D
D
S
V
H
N
A
D
Y
Y
Site 134
Y1074
D
S
V
H
N
A
D
Y
Y
M
Q
E
A
K
K
Site 135
Y1075
S
V
H
N
A
D
Y
Y
M
Q
E
A
K
K
L
Site 136
S1105
N
Y
A
D
A
A
L
S
F
T
E
C
G
N
A
Site 137
S1122
R
D
P
L
E
A
K
S
P
Y
T
M
Y
S
E
Site 138
Y1124
P
L
E
A
K
S
P
Y
T
M
Y
S
E
T
V
Site 139
Y1127
A
K
S
P
Y
T
M
Y
S
E
T
V
E
L
L
Site 140
S1128
K
S
P
Y
T
M
Y
S
E
T
V
E
L
L
R
Site 141
Y1136
E
T
V
E
L
L
R
Y
A
M
R
L
K
N
F
Site 142
S1145
M
R
L
K
N
F
A
S
P
L
A
S
D
G
D
Site 143
S1149
N
F
A
S
P
L
A
S
D
G
D
K
K
L
A
Site 144
Y1181
K
K
D
H
A
M
K
Y
S
R
S
L
M
E
Y
Site 145
Y1188
Y
S
R
S
L
M
E
Y
F
K
Q
N
A
S
K
Site 146
S1201
S
K
V
A
Q
I
P
S
P
W
V
S
N
G
K
Site 147
S1205
Q
I
P
S
P
W
V
S
N
G
K
N
T
P
S
Site 148
T1210
W
V
S
N
G
K
N
T
P
S
P
V
S
L
N
Site 149
S1212
S
N
G
K
N
T
P
S
P
V
S
L
N
N
V
Site 150
S1215
K
N
T
P
S
P
V
S
L
N
N
V
S
P
I
Site 151
S1220
P
V
S
L
N
N
V
S
P
I
N
A
M
G
N
Site 152
Y1257
T
S
N
V
L
R
G
Y
E
H
W
D
M
A
D
Site 153
T1285
D
T
L
M
G
P
L
T
Q
H
S
S
M
T
N
Site 154
S1289
G
P
L
T
Q
H
S
S
M
T
N
L
V
R
Y
Site 155
Y1296
S
M
T
N
L
V
R
Y
V
R
Q
G
L
C
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation