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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFF1
Full Name:
AF4/FMR2 family member 1
Alias:
af4; AF4/FMR2 family, member 1; aff1; fel; mllt2; myeloid/lymphoid or mixed-lineage leukemia (trithorax), translocated to, 2 (AF4); PBM1; proto-oncogene AF4
Type:
Transcription protein
Mass (Da):
131422
Number AA:
1210
UniProt ID:
P51825
International Prot ID:
IPI00396310
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y45
I
P
L
F
G
E
P
Y
K
T
A
K
G
D
E
Site 2
T47
L
F
G
E
P
Y
K
T
A
K
G
D
E
L
S
Site 3
S54
T
A
K
G
D
E
L
S
S
R
I
Q
N
M
L
Site 4
Y64
I
Q
N
M
L
G
N
Y
E
E
V
K
E
F
L
Site 5
S72
E
E
V
K
E
F
L
S
T
K
S
H
T
H
R
Site 6
T73
E
V
K
E
F
L
S
T
K
S
H
T
H
R
L
Site 7
S75
K
E
F
L
S
T
K
S
H
T
H
R
L
D
A
Site 8
S83
H
T
H
R
L
D
A
S
E
N
R
L
G
K
P
Site 9
Y92
N
R
L
G
K
P
K
Y
P
L
I
P
D
K
G
Site 10
S100
P
L
I
P
D
K
G
S
S
I
P
S
S
S
F
Site 11
S101
L
I
P
D
K
G
S
S
I
P
S
S
S
F
H
Site 12
S104
D
K
G
S
S
I
P
S
S
S
F
H
T
S
V
Site 13
S105
K
G
S
S
I
P
S
S
S
F
H
T
S
V
H
Site 14
S106
G
S
S
I
P
S
S
S
F
H
T
S
V
H
H
Site 15
T109
I
P
S
S
S
F
H
T
S
V
H
H
Q
S
I
Site 16
S110
P
S
S
S
F
H
T
S
V
H
H
Q
S
I
H
Site 17
S115
H
T
S
V
H
H
Q
S
I
H
T
P
A
S
G
Site 18
T118
V
H
H
Q
S
I
H
T
P
A
S
G
P
L
S
Site 19
S121
Q
S
I
H
T
P
A
S
G
P
L
S
V
G
N
Site 20
S125
T
P
A
S
G
P
L
S
V
G
N
I
S
H
N
Site 21
S130
P
L
S
V
G
N
I
S
H
N
P
K
M
A
Q
Site 22
T140
P
K
M
A
Q
P
R
T
E
P
M
P
S
L
H
Site 23
S145
P
R
T
E
P
M
P
S
L
H
A
K
S
C
G
Site 24
S150
M
P
S
L
H
A
K
S
C
G
P
P
D
S
Q
Site 25
S156
K
S
C
G
P
P
D
S
Q
H
L
T
Q
D
R
Site 26
T160
P
P
D
S
Q
H
L
T
Q
D
R
L
G
Q
E
Site 27
S171
L
G
Q
E
G
F
G
S
S
H
H
K
K
G
D
Site 28
S172
G
Q
E
G
F
G
S
S
H
H
K
K
G
D
R
Site 29
S188
A
D
G
D
H
C
A
S
V
T
D
S
A
P
E
Site 30
S192
H
C
A
S
V
T
D
S
A
P
E
R
E
L
S
Site 31
S199
S
A
P
E
R
E
L
S
P
L
I
S
L
P
S
Site 32
S203
R
E
L
S
P
L
I
S
L
P
S
P
V
P
P
Site 33
S206
S
P
L
I
S
L
P
S
P
V
P
P
L
S
P
Site 34
S212
P
S
P
V
P
P
L
S
P
I
H
S
N
Q
Q
Site 35
S216
P
P
L
S
P
I
H
S
N
Q
Q
T
L
P
R
Site 36
T220
P
I
H
S
N
Q
Q
T
L
P
R
T
Q
G
S
Site 37
T224
N
Q
Q
T
L
P
R
T
Q
G
S
S
K
V
H
Site 38
S227
T
L
P
R
T
Q
G
S
S
K
V
H
G
S
S
Site 39
S228
L
P
R
T
Q
G
S
S
K
V
H
G
S
S
N
Site 40
S233
G
S
S
K
V
H
G
S
S
N
N
S
K
G
Y
Site 41
S234
S
S
K
V
H
G
S
S
N
N
S
K
G
Y
C
Site 42
S237
V
H
G
S
S
N
N
S
K
G
Y
C
P
A
K
Site 43
Y240
S
S
N
N
S
K
G
Y
C
P
A
K
S
P
K
Site 44
S245
K
G
Y
C
P
A
K
S
P
K
D
L
A
V
K
Site 45
T258
V
K
V
H
D
K
E
T
P
Q
D
S
L
V
A
Site 46
S271
V
A
P
A
Q
P
P
S
Q
T
F
P
P
P
S
Site 47
T273
P
A
Q
P
P
S
Q
T
F
P
P
P
S
L
P
Site 48
S278
S
Q
T
F
P
P
P
S
L
P
S
K
S
V
A
Site 49
S281
F
P
P
P
S
L
P
S
K
S
V
A
M
Q
Q
Site 50
S283
P
P
S
L
P
S
K
S
V
A
M
Q
Q
K
P
Site 51
Y293
M
Q
Q
K
P
T
A
Y
V
R
P
M
D
G
Q
Site 52
S305
D
G
Q
D
Q
A
P
S
E
S
P
E
L
K
P
Site 53
S307
Q
D
Q
A
P
S
E
S
P
E
L
K
P
L
P
Site 54
Y317
L
K
P
L
P
E
D
Y
R
Q
Q
T
F
E
K
Site 55
T321
P
E
D
Y
R
Q
Q
T
F
E
K
T
D
L
K
Site 56
T325
R
Q
Q
T
F
E
K
T
D
L
K
V
P
A
K
Site 57
S342
L
T
K
L
K
M
P
S
Q
S
V
E
Q
T
Y
Site 58
S344
K
L
K
M
P
S
Q
S
V
E
Q
T
Y
S
N
Site 59
T348
P
S
Q
S
V
E
Q
T
Y
S
N
E
V
H
C
Site 60
S350
Q
S
V
E
Q
T
Y
S
N
E
V
H
C
V
E
Site 61
S366
I
L
K
E
M
T
H
S
W
P
P
P
L
T
A
Site 62
T372
H
S
W
P
P
P
L
T
A
I
H
T
P
S
T
Site 63
T376
P
P
L
T
A
I
H
T
P
S
T
A
E
P
S
Site 64
S378
L
T
A
I
H
T
P
S
T
A
E
P
S
K
F
Site 65
T379
T
A
I
H
T
P
S
T
A
E
P
S
K
F
P
Site 66
S383
T
P
S
T
A
E
P
S
K
F
P
F
P
T
K
Site 67
S392
F
P
F
P
T
K
D
S
Q
H
V
S
S
V
T
Site 68
S396
T
K
D
S
Q
H
V
S
S
V
T
Q
N
Q
K
Site 69
S397
K
D
S
Q
H
V
S
S
V
T
Q
N
Q
K
Q
Site 70
Y405
V
T
Q
N
Q
K
Q
Y
D
T
S
S
K
T
H
Site 71
T407
Q
N
Q
K
Q
Y
D
T
S
S
K
T
H
S
N
Site 72
S409
Q
K
Q
Y
D
T
S
S
K
T
H
S
N
S
Q
Site 73
T411
Q
Y
D
T
S
S
K
T
H
S
N
S
Q
Q
G
Site 74
S413
D
T
S
S
K
T
H
S
N
S
Q
Q
G
T
S
Site 75
S415
S
S
K
T
H
S
N
S
Q
Q
G
T
S
S
M
Site 76
T419
H
S
N
S
Q
Q
G
T
S
S
M
L
E
D
D
Site 77
S421
N
S
Q
Q
G
T
S
S
M
L
E
D
D
L
Q
Site 78
S430
L
E
D
D
L
Q
L
S
D
S
E
D
S
D
S
Site 79
S432
D
D
L
Q
L
S
D
S
E
D
S
D
S
E
Q
Site 80
S435
Q
L
S
D
S
E
D
S
D
S
E
Q
T
P
E
Site 81
S437
S
D
S
E
D
S
D
S
E
Q
T
P
E
K
P
Site 82
T440
E
D
S
D
S
E
Q
T
P
E
K
P
P
S
S
Site 83
S446
Q
T
P
E
K
P
P
S
S
S
A
P
P
S
A
Site 84
S447
T
P
E
K
P
P
S
S
S
A
P
P
S
A
P
Site 85
S448
P
E
K
P
P
S
S
S
A
P
P
S
A
P
Q
Site 86
S452
P
S
S
S
A
P
P
S
A
P
Q
S
L
P
E
Site 87
S456
A
P
P
S
A
P
Q
S
L
P
E
P
V
A
S
Site 88
S463
S
L
P
E
P
V
A
S
A
H
S
S
S
A
E
Site 89
S466
E
P
V
A
S
A
H
S
S
S
A
E
S
E
S
Site 90
S467
P
V
A
S
A
H
S
S
S
A
E
S
E
S
T
Site 91
S468
V
A
S
A
H
S
S
S
A
E
S
E
S
T
S
Site 92
S471
A
H
S
S
S
A
E
S
E
S
T
S
D
S
D
Site 93
S473
S
S
S
A
E
S
E
S
T
S
D
S
D
S
S
Site 94
T474
S
S
A
E
S
E
S
T
S
D
S
D
S
S
S
Site 95
S475
S
A
E
S
E
S
T
S
D
S
D
S
S
S
D
Site 96
S477
E
S
E
S
T
S
D
S
D
S
S
S
D
S
E
Site 97
S479
E
S
T
S
D
S
D
S
S
S
D
S
E
S
E
Site 98
S480
S
T
S
D
S
D
S
S
S
D
S
E
S
E
S
Site 99
S481
T
S
D
S
D
S
S
S
D
S
E
S
E
S
S
Site 100
S483
D
S
D
S
S
S
D
S
E
S
E
S
S
S
S
Site 101
S485
D
S
S
S
D
S
E
S
E
S
S
S
S
D
S
Site 102
S487
S
S
D
S
E
S
E
S
S
S
S
D
S
E
E
Site 103
S488
S
D
S
E
S
E
S
S
S
S
D
S
E
E
N
Site 104
S489
D
S
E
S
E
S
S
S
S
D
S
E
E
N
E
Site 105
S490
S
E
S
E
S
S
S
S
D
S
E
E
N
E
P
Site 106
S492
S
E
S
S
S
S
D
S
E
E
N
E
P
L
E
Site 107
T500
E
E
N
E
P
L
E
T
P
A
P
E
P
E
P
Site 108
T510
P
E
P
E
P
P
T
T
N
K
W
Q
L
D
N
Site 109
S523
D
N
W
L
T
K
V
S
Q
P
A
A
P
P
E
Site 110
S534
A
P
P
E
G
P
R
S
T
E
P
P
R
R
H
Site 111
T535
P
P
E
G
P
R
S
T
E
P
P
R
R
H
P
Site 112
S544
P
P
R
R
H
P
E
S
K
G
S
S
D
S
A
Site 113
S547
R
H
P
E
S
K
G
S
S
D
S
A
T
S
Q
Site 114
S548
H
P
E
S
K
G
S
S
D
S
A
T
S
Q
E
Site 115
S550
E
S
K
G
S
S
D
S
A
T
S
Q
E
H
S
Site 116
T552
K
G
S
S
D
S
A
T
S
Q
E
H
S
E
S
Site 117
S553
G
S
S
D
S
A
T
S
Q
E
H
S
E
S
K
Site 118
S557
S
A
T
S
Q
E
H
S
E
S
K
D
P
P
P
Site 119
S559
T
S
Q
E
H
S
E
S
K
D
P
P
P
K
S
Site 120
S566
S
K
D
P
P
P
K
S
S
S
K
A
P
R
A
Site 121
S568
D
P
P
P
K
S
S
S
K
A
P
R
A
P
P
Site 122
S584
A
P
H
P
G
K
R
S
C
Q
K
S
P
A
Q
Site 123
S588
G
K
R
S
C
Q
K
S
P
A
Q
Q
E
P
P
Site 124
T599
Q
E
P
P
Q
R
Q
T
V
G
T
K
Q
P
K
Site 125
T602
P
Q
R
Q
T
V
G
T
K
Q
P
K
K
P
V
Site 126
S612
P
K
K
P
V
K
A
S
A
R
A
G
S
R
T
Site 127
S617
K
A
S
A
R
A
G
S
R
T
S
L
Q
G
E
Site 128
T619
S
A
R
A
G
S
R
T
S
L
Q
G
E
R
E
Site 129
S620
A
R
A
G
S
R
T
S
L
Q
G
E
R
E
P
Site 130
Y632
R
E
P
G
L
L
P
Y
G
S
R
D
Q
T
S
Site 131
S634
P
G
L
L
P
Y
G
S
R
D
Q
T
S
K
D
Site 132
T638
P
Y
G
S
R
D
Q
T
S
K
D
K
P
K
V
Site 133
S639
Y
G
S
R
D
Q
T
S
K
D
K
P
K
V
K
Site 134
S656
G
R
P
R
A
A
A
S
N
E
P
K
P
A
V
Site 135
S666
P
K
P
A
V
P
P
S
S
E
K
K
K
H
K
Site 136
S667
K
P
A
V
P
P
S
S
E
K
K
K
H
K
S
Site 137
S674
S
E
K
K
K
H
K
S
S
L
P
A
P
S
K
Site 138
S675
E
K
K
K
H
K
S
S
L
P
A
P
S
K
A
Site 139
S680
K
S
S
L
P
A
P
S
K
A
L
S
G
P
E
Site 140
S684
P
A
P
S
K
A
L
S
G
P
E
P
A
K
D
Site 141
T697
K
D
N
V
E
D
R
T
P
E
H
F
A
L
V
Site 142
T707
H
F
A
L
V
P
L
T
E
S
Q
G
P
P
H
Site 143
S709
A
L
V
P
L
T
E
S
Q
G
P
P
H
S
G
Site 144
S715
E
S
Q
G
P
P
H
S
G
S
G
S
R
T
S
Site 145
S717
Q
G
P
P
H
S
G
S
G
S
R
T
S
G
C
Site 146
S719
P
P
H
S
G
S
G
S
R
T
S
G
C
R
Q
Site 147
T721
H
S
G
S
G
S
R
T
S
G
C
R
Q
A
V
Site 148
S722
S
G
S
G
S
R
T
S
G
C
R
Q
A
V
V
Site 149
S734
A
V
V
V
Q
E
D
S
R
K
D
R
L
P
L
Site 150
T746
L
P
L
P
L
R
D
T
K
L
L
S
P
L
R
Site 151
S750
L
R
D
T
K
L
L
S
P
L
R
D
T
P
P
Site 152
T755
L
L
S
P
L
R
D
T
P
P
P
Q
S
L
M
Site 153
S760
R
D
T
P
P
P
Q
S
L
M
V
K
I
T
L
Site 154
T766
Q
S
L
M
V
K
I
T
L
D
L
L
S
R
I
Site 155
S771
K
I
T
L
D
L
L
S
R
I
P
Q
P
P
G
Site 156
S798
P
P
A
G
K
K
H
S
S
E
K
R
S
S
D
Site 157
S799
P
A
G
K
K
H
S
S
E
K
R
S
S
D
S
Site 158
S803
K
H
S
S
E
K
R
S
S
D
S
S
S
K
L
Site 159
S804
H
S
S
E
K
R
S
S
D
S
S
S
K
L
A
Site 160
S806
S
E
K
R
S
S
D
S
S
S
K
L
A
K
K
Site 161
S807
E
K
R
S
S
D
S
S
S
K
L
A
K
K
R
Site 162
S808
K
R
S
S
D
S
S
S
K
L
A
K
K
R
K
Site 163
S835
R
L
E
K
E
I
K
S
Q
S
S
S
S
S
S
Site 164
S837
E
K
E
I
K
S
Q
S
S
S
S
S
S
S
H
Site 165
S838
K
E
I
K
S
Q
S
S
S
S
S
S
S
H
K
Site 166
S839
E
I
K
S
Q
S
S
S
S
S
S
S
H
K
E
Site 167
S840
I
K
S
Q
S
S
S
S
S
S
S
H
K
E
S
Site 168
S841
K
S
Q
S
S
S
S
S
S
S
H
K
E
S
S
Site 169
S842
S
Q
S
S
S
S
S
S
S
H
K
E
S
S
K
Site 170
S843
Q
S
S
S
S
S
S
S
H
K
E
S
S
K
T
Site 171
S847
S
S
S
S
H
K
E
S
S
K
T
K
P
S
R
Site 172
S848
S
S
S
H
K
E
S
S
K
T
K
P
S
R
P
Site 173
T850
S
H
K
E
S
S
K
T
K
P
S
R
P
S
S
Site 174
S853
E
S
S
K
T
K
P
S
R
P
S
S
Q
S
S
Site 175
S856
K
T
K
P
S
R
P
S
S
Q
S
S
K
K
E
Site 176
S857
T
K
P
S
R
P
S
S
Q
S
S
K
K
E
M
Site 177
S859
P
S
R
P
S
S
Q
S
S
K
K
E
M
L
P
Site 178
S860
S
R
P
S
S
Q
S
S
K
K
E
M
L
P
P
Site 179
S871
M
L
P
P
P
P
V
S
S
S
S
Q
K
P
A
Site 180
S872
L
P
P
P
P
V
S
S
S
S
Q
K
P
A
K
Site 181
S873
P
P
P
P
V
S
S
S
S
Q
K
P
A
K
P
Site 182
S874
P
P
P
V
S
S
S
S
Q
K
P
A
K
P
A
Site 183
S885
A
K
P
A
L
K
R
S
R
R
E
A
D
T
C
Site 184
T891
R
S
R
R
E
A
D
T
C
G
Q
D
P
P
K
Site 185
S899
C
G
Q
D
P
P
K
S
A
S
S
T
K
S
N
Site 186
S901
Q
D
P
P
K
S
A
S
S
T
K
S
N
H
K
Site 187
S902
D
P
P
K
S
A
S
S
T
K
S
N
H
K
D
Site 188
T903
P
P
K
S
A
S
S
T
K
S
N
H
K
D
S
Site 189
S905
K
S
A
S
S
T
K
S
N
H
K
D
S
S
I
Site 190
S911
K
S
N
H
K
D
S
S
I
P
K
Q
R
R
V
Site 191
S923
R
R
V
E
G
K
G
S
R
S
S
S
E
H
K
Site 192
S925
V
E
G
K
G
S
R
S
S
S
E
H
K
G
S
Site 193
S926
E
G
K
G
S
R
S
S
S
E
H
K
G
S
S
Site 194
S927
G
K
G
S
R
S
S
S
E
H
K
G
S
S
G
Site 195
S932
S
S
S
E
H
K
G
S
S
G
D
T
A
N
P
Site 196
T936
H
K
G
S
S
G
D
T
A
N
P
F
P
V
P
Site 197
S944
A
N
P
F
P
V
P
S
L
P
N
G
N
S
K
Site 198
S950
P
S
L
P
N
G
N
S
K
P
G
K
P
Q
V
Site 199
T1005
F
I
E
C
G
I
A
T
E
S
E
S
Q
S
S
Site 200
S1007
E
C
G
I
A
T
E
S
E
S
Q
S
S
K
S
Site 201
S1009
G
I
A
T
E
S
E
S
Q
S
S
K
S
A
Y
Site 202
S1011
A
T
E
S
E
S
Q
S
S
K
S
A
Y
S
V
Site 203
S1012
T
E
S
E
S
Q
S
S
K
S
A
Y
S
V
Y
Site 204
S1014
S
E
S
Q
S
S
K
S
A
Y
S
V
Y
S
E
Site 205
Y1016
S
Q
S
S
K
S
A
Y
S
V
Y
S
E
T
V
Site 206
S1017
Q
S
S
K
S
A
Y
S
V
Y
S
E
T
V
D
Site 207
S1020
K
S
A
Y
S
V
Y
S
E
T
V
D
L
I
K
Site 208
T1039
L
K
S
F
S
D
A
T
A
P
T
Q
E
K
I
Site 209
T1042
F
S
D
A
T
A
P
T
Q
E
K
I
F
A
V
Site 210
Y1073
K
K
D
I
A
I
K
Y
S
R
T
L
N
K
H
Site 211
S1085
N
K
H
F
E
S
S
S
K
V
A
Q
A
P
S
Site 212
S1092
S
K
V
A
Q
A
P
S
P
C
I
A
S
T
G
Site 213
T1098
P
S
P
C
I
A
S
T
G
T
P
S
P
L
S
Site 214
S1102
I
A
S
T
G
T
P
S
P
L
S
P
M
P
S
Site 215
S1105
T
G
T
P
S
P
L
S
P
M
P
S
P
A
S
Site 216
S1109
S
P
L
S
P
M
P
S
P
A
S
S
V
G
S
Site 217
S1112
S
P
M
P
S
P
A
S
S
V
G
S
Q
S
S
Site 218
S1113
P
M
P
S
P
A
S
S
V
G
S
Q
S
S
A
Site 219
S1116
S
P
A
S
S
V
G
S
Q
S
S
A
G
S
V
Site 220
S1118
A
S
S
V
G
S
Q
S
S
A
G
S
V
G
S
Site 221
S1119
S
S
V
G
S
Q
S
S
A
G
S
V
G
S
S
Site 222
S1122
G
S
Q
S
S
A
G
S
V
G
S
S
G
V
A
Site 223
S1144
T
I
Q
N
M
T
S
S
Y
V
T
I
T
S
H
Site 224
Y1195
S
L
V
D
L
V
H
Y
T
R
Q
G
F
Q
Q
Site 225
T1209
Q
L
Q
E
L
T
K
T
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation