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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFF3
Full Name:
AF4/FMR2 family member 3
Alias:
Af4/fmr2 family 3; AF4/FMR2 family, member 3; Aff3; Laf4; Laf-4; Lymphoid nuclear protein related to AF4; MLLT2-like
Type:
Transcription factor
Mass (Da):
133480
Number AA:
UniProt ID:
P51826
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
Q
E
W
D
L
E
S
L
C
V
Y
E
P
D
Site 2
Y20
D
L
E
S
L
C
V
Y
E
P
D
R
N
A
L
Site 3
T39
R
E
R
R
N
Q
E
T
Q
Q
D
D
G
T
F
Site 4
T45
E
T
Q
Q
D
D
G
T
F
N
S
S
Y
S
L
Site 5
S48
Q
D
D
G
T
F
N
S
S
Y
S
L
F
S
E
Site 6
S49
D
D
G
T
F
N
S
S
Y
S
L
F
S
E
P
Site 7
Y50
D
G
T
F
N
S
S
Y
S
L
F
S
E
P
Y
Site 8
S51
G
T
F
N
S
S
Y
S
L
F
S
E
P
Y
K
Site 9
S54
N
S
S
Y
S
L
F
S
E
P
Y
K
T
N
K
Site 10
T59
L
F
S
E
P
Y
K
T
N
K
G
D
E
L
S
Site 11
S66
T
N
K
G
D
E
L
S
N
R
I
Q
N
T
L
Site 12
T84
D
E
M
K
D
F
L
T
D
R
S
N
Q
S
H
Site 13
S87
K
D
F
L
T
D
R
S
N
Q
S
H
L
V
G
Site 14
T103
P
K
P
G
V
P
Q
T
P
V
N
K
I
D
E
Site 15
S123
S
R
A
Q
N
Q
P
S
S
I
C
S
T
T
T
Site 16
S124
R
A
Q
N
Q
P
S
S
I
C
S
T
T
T
S
Site 17
S127
N
Q
P
S
S
I
C
S
T
T
T
S
T
P
A
Site 18
T128
Q
P
S
S
I
C
S
T
T
T
S
T
P
A
A
Site 19
S141
A
A
V
P
V
Q
Q
S
K
R
G
T
M
G
W
Site 20
T145
V
Q
Q
S
K
R
G
T
M
G
W
Q
K
A
G
Site 21
S156
Q
K
A
G
H
P
P
S
D
G
Q
Q
R
A
T
Site 22
T163
S
D
G
Q
Q
R
A
T
Q
Q
G
S
L
R
T
Site 23
S167
Q
R
A
T
Q
Q
G
S
L
R
T
L
L
G
D
Site 24
S207
P
A
M
A
A
K
H
S
S
S
G
H
C
V
Q
Site 25
S219
C
V
Q
N
F
P
P
S
L
A
S
K
P
S
L
Site 26
S225
P
S
L
A
S
K
P
S
L
V
Q
Q
K
P
T
Site 27
T232
S
L
V
Q
Q
K
P
T
A
Y
V
R
P
M
D
Site 28
Y234
V
Q
Q
K
P
T
A
Y
V
R
P
M
D
G
Q
Site 29
S248
Q
D
Q
A
P
D
E
S
P
K
L
K
S
S
S
Site 30
S253
D
E
S
P
K
L
K
S
S
S
E
T
S
V
H
Site 31
S254
E
S
P
K
L
K
S
S
S
E
T
S
V
H
C
Site 32
S255
S
P
K
L
K
S
S
S
E
T
S
V
H
C
T
Site 33
T257
K
L
K
S
S
S
E
T
S
V
H
C
T
S
Y
Site 34
S258
L
K
S
S
S
E
T
S
V
H
C
T
S
Y
R
Site 35
T262
S
E
T
S
V
H
C
T
S
Y
R
G
V
P
A
Site 36
S263
E
T
S
V
H
C
T
S
Y
R
G
V
P
A
S
Site 37
S270
S
Y
R
G
V
P
A
S
K
P
E
P
A
R
A
Site 38
S282
A
R
A
K
A
K
L
S
K
F
S
I
P
K
Q
Site 39
S295
K
Q
G
E
E
S
R
S
G
E
T
N
S
C
V
Site 40
S300
S
R
S
G
E
T
N
S
C
V
E
E
I
I
R
Site 41
T310
E
E
I
I
R
E
M
T
W
L
P
P
L
S
A
Site 42
S316
M
T
W
L
P
P
L
S
A
I
Q
A
P
G
K
Site 43
T327
A
P
G
K
V
E
P
T
K
F
P
F
P
N
K
Site 44
S336
F
P
F
P
N
K
D
S
Q
L
V
S
S
G
H
Site 45
S340
N
K
D
S
Q
L
V
S
S
G
H
N
N
P
K
Site 46
S355
K
G
D
A
E
P
E
S
P
D
S
G
T
S
N
Site 47
S358
A
E
P
E
S
P
D
S
G
T
S
N
T
S
M
Site 48
T360
P
E
S
P
D
S
G
T
S
N
T
S
M
L
E
Site 49
S361
E
S
P
D
S
G
T
S
N
T
S
M
L
E
D
Site 50
S374
E
D
D
L
K
L
S
S
D
E
E
E
N
E
Q
Site 51
S393
R
T
A
L
R
A
L
S
D
S
A
V
V
Q
Q
Site 52
S395
A
L
R
A
L
S
D
S
A
V
V
Q
Q
P
N
Site 53
T405
V
Q
Q
P
N
C
R
T
S
V
P
S
S
K
G
Site 54
S406
Q
Q
P
N
C
R
T
S
V
P
S
S
K
G
S
Site 55
S409
N
C
R
T
S
V
P
S
S
K
G
S
S
S
S
Site 56
S410
C
R
T
S
V
P
S
S
K
G
S
S
S
S
S
Site 57
S413
S
V
P
S
S
K
G
S
S
S
S
S
S
S
G
Site 58
S414
V
P
S
S
K
G
S
S
S
S
S
S
S
G
S
Site 59
S415
P
S
S
K
G
S
S
S
S
S
S
S
G
S
S
Site 60
S416
S
S
K
G
S
S
S
S
S
S
S
G
S
S
S
Site 61
S417
S
K
G
S
S
S
S
S
S
S
G
S
S
S
S
Site 62
S418
K
G
S
S
S
S
S
S
S
G
S
S
S
S
S
Site 63
S419
G
S
S
S
S
S
S
S
G
S
S
S
S
S
S
Site 64
S421
S
S
S
S
S
S
G
S
S
S
S
S
S
D
S
Site 65
S422
S
S
S
S
S
G
S
S
S
S
S
S
D
S
E
Site 66
S423
S
S
S
S
G
S
S
S
S
S
S
D
S
E
S
Site 67
S424
S
S
S
G
S
S
S
S
S
S
D
S
E
S
S
Site 68
S425
S
S
G
S
S
S
S
S
S
D
S
E
S
S
S
Site 69
S426
S
G
S
S
S
S
S
S
D
S
E
S
S
S
G
Site 70
S428
S
S
S
S
S
S
D
S
E
S
S
S
G
S
D
Site 71
S430
S
S
S
S
D
S
E
S
S
S
G
S
D
S
E
Site 72
S431
S
S
S
D
S
E
S
S
S
G
S
D
S
E
T
Site 73
S432
S
S
D
S
E
S
S
S
G
S
D
S
E
T
E
Site 74
S434
D
S
E
S
S
S
G
S
D
S
E
T
E
S
S
Site 75
S436
E
S
S
S
G
S
D
S
E
T
E
S
S
S
S
Site 76
T438
S
S
G
S
D
S
E
T
E
S
S
S
S
E
S
Site 77
S440
G
S
D
S
E
T
E
S
S
S
S
E
S
E
G
Site 78
S441
S
D
S
E
T
E
S
S
S
S
E
S
E
G
S
Site 79
S442
D
S
E
T
E
S
S
S
S
E
S
E
G
S
K
Site 80
S443
S
E
T
E
S
S
S
S
E
S
E
G
S
K
P
Site 81
S445
T
E
S
S
S
S
E
S
E
G
S
K
P
P
H
Site 82
S448
S
S
S
E
S
E
G
S
K
P
P
H
F
S
S
Site 83
S455
S
K
P
P
H
F
S
S
P
E
A
E
P
A
S
Site 84
S462
S
P
E
A
E
P
A
S
S
N
K
W
Q
L
D
Site 85
S463
P
E
A
E
P
A
S
S
N
K
W
Q
L
D
K
Site 86
S488
P
I
L
I
Q
N
E
S
H
G
S
E
S
N
Q
Site 87
S491
I
Q
N
E
S
H
G
S
E
S
N
Q
Y
Y
N
Site 88
Y496
H
G
S
E
S
N
Q
Y
Y
N
P
V
K
E
D
Site 89
Y497
G
S
E
S
N
Q
Y
Y
N
P
V
K
E
D
V
Site 90
S517
V
P
D
V
C
Q
P
S
L
R
E
K
E
I
K
Site 91
S525
L
R
E
K
E
I
K
S
T
C
K
E
E
Q
R
Site 92
T526
R
E
K
E
I
K
S
T
C
K
E
E
Q
R
P
Site 93
T535
K
E
E
Q
R
P
R
T
A
N
K
A
P
G
S
Site 94
S542
T
A
N
K
A
P
G
S
K
G
V
K
Q
K
S
Site 95
S549
S
K
G
V
K
Q
K
S
P
P
A
A
V
A
V
Site 96
S582
A
P
A
P
A
R
R
S
A
G
K
K
P
T
R
Site 97
T591
G
K
K
P
T
R
R
T
E
R
T
S
A
G
D
Site 98
T594
P
T
R
R
T
E
R
T
S
A
G
D
G
A
N
Site 99
S595
T
R
R
T
E
R
T
S
A
G
D
G
A
N
C
Site 100
T627
V
P
P
E
P
T
K
T
R
P
C
G
N
N
R
Site 101
S636
P
C
G
N
N
R
A
S
H
R
K
E
L
R
S
Site 102
S643
S
H
R
K
E
L
R
S
S
V
T
C
E
K
R
Site 103
S644
H
R
K
E
L
R
S
S
V
T
C
E
K
R
R
Site 104
T652
V
T
C
E
K
R
R
T
R
G
L
S
R
I
V
Site 105
S656
K
R
R
T
R
G
L
S
R
I
V
P
K
S
K
Site 106
S662
L
S
R
I
V
P
K
S
K
E
F
I
E
T
E
Site 107
T668
K
S
K
E
F
I
E
T
E
S
S
S
S
S
S
Site 108
S670
K
E
F
I
E
T
E
S
S
S
S
S
S
S
S
Site 109
S671
E
F
I
E
T
E
S
S
S
S
S
S
S
S
D
Site 110
S672
F
I
E
T
E
S
S
S
S
S
S
S
S
D
S
Site 111
S673
I
E
T
E
S
S
S
S
S
S
S
S
D
S
D
Site 112
S674
E
T
E
S
S
S
S
S
S
S
S
D
S
D
L
Site 113
S675
T
E
S
S
S
S
S
S
S
S
D
S
D
L
E
Site 114
S676
E
S
S
S
S
S
S
S
S
D
S
D
L
E
S
Site 115
S677
S
S
S
S
S
S
S
S
D
S
D
L
E
S
E
Site 116
S679
S
S
S
S
S
S
D
S
D
L
E
S
E
Q
E
Site 117
S683
S
S
D
S
D
L
E
S
E
Q
E
E
Y
P
L
Site 118
Y688
L
E
S
E
Q
E
E
Y
P
L
S
K
A
Q
T
Site 119
S691
E
Q
E
E
Y
P
L
S
K
A
Q
T
V
A
A
Site 120
T695
Y
P
L
S
K
A
Q
T
V
A
A
S
A
S
S
Site 121
S699
K
A
Q
T
V
A
A
S
A
S
S
G
N
D
Q
Site 122
S701
Q
T
V
A
A
S
A
S
S
G
N
D
Q
R
L
Site 123
S717
E
A
A
A
N
G
G
S
G
P
R
A
P
V
G
Site 124
S725
G
P
R
A
P
V
G
S
I
N
A
R
T
T
S
Site 125
T731
G
S
I
N
A
R
T
T
S
D
I
A
K
E
L
Site 126
S732
S
I
N
A
R
T
T
S
D
I
A
K
E
L
E
Site 127
Y743
K
E
L
E
E
Q
F
Y
T
L
V
P
F
G
R
Site 128
T744
E
L
E
E
Q
F
Y
T
L
V
P
F
G
R
N
Site 129
S755
F
G
R
N
E
L
L
S
P
L
K
D
S
D
E
Site 130
S760
L
L
S
P
L
K
D
S
D
E
I
R
S
L
W
Site 131
T773
L
W
V
K
I
D
L
T
L
L
S
R
I
P
E
Site 132
S776
K
I
D
L
T
L
L
S
R
I
P
E
H
L
P
Site 133
S790
P
Q
E
P
G
V
L
S
A
P
A
T
K
D
S
Site 134
T794
G
V
L
S
A
P
A
T
K
D
S
E
S
A
P
Site 135
S797
S
A
P
A
T
K
D
S
E
S
A
P
P
S
H
Site 136
S799
P
A
T
K
D
S
E
S
A
P
P
S
H
T
S
Site 137
S803
D
S
E
S
A
P
P
S
H
T
S
D
T
P
A
Site 138
S806
S
A
P
P
S
H
T
S
D
T
P
A
E
K
A
Site 139
T808
P
P
S
H
T
S
D
T
P
A
E
K
A
L
P
Site 140
S817
A
E
K
A
L
P
K
S
K
R
K
R
K
C
D
Site 141
Y829
K
C
D
N
E
D
D
Y
R
E
I
K
K
S
Q
Site 142
S835
D
Y
R
E
I
K
K
S
Q
G
E
K
D
S
S
Site 143
S841
K
S
Q
G
E
K
D
S
S
S
R
L
A
T
S
Site 144
S842
S
Q
G
E
K
D
S
S
S
R
L
A
T
S
T
Site 145
S843
Q
G
E
K
D
S
S
S
R
L
A
T
S
T
S
Site 146
T847
D
S
S
S
R
L
A
T
S
T
S
N
T
L
S
Site 147
S848
S
S
S
R
L
A
T
S
T
S
N
T
L
S
A
Site 148
T849
S
S
R
L
A
T
S
T
S
N
T
L
S
A
N
Site 149
S850
S
R
L
A
T
S
T
S
N
T
L
S
A
N
H
Site 150
T852
L
A
T
S
T
S
N
T
L
S
A
N
H
C
N
Site 151
S864
H
C
N
M
N
I
N
S
V
A
I
P
I
N
K
Site 152
S878
K
N
E
K
M
L
R
S
P
I
S
P
L
S
D
Site 153
S881
K
M
L
R
S
P
I
S
P
L
S
D
A
S
K
Site 154
S884
R
S
P
I
S
P
L
S
D
A
S
K
H
K
Y
Site 155
S887
I
S
P
L
S
D
A
S
K
H
K
Y
T
S
E
Site 156
Y891
S
D
A
S
K
H
K
Y
T
S
E
D
L
T
S
Site 157
S893
A
S
K
H
K
Y
T
S
E
D
L
T
S
S
S
Site 158
T897
K
Y
T
S
E
D
L
T
S
S
S
R
P
N
G
Site 159
S898
Y
T
S
E
D
L
T
S
S
S
R
P
N
G
N
Site 160
S899
T
S
E
D
L
T
S
S
S
R
P
N
G
N
S
Site 161
S900
S
E
D
L
T
S
S
S
R
P
N
G
N
S
L
Site 162
S906
S
S
R
P
N
G
N
S
L
F
T
S
A
S
S
Site 163
T909
P
N
G
N
S
L
F
T
S
A
S
S
S
K
K
Site 164
S910
N
G
N
S
L
F
T
S
A
S
S
S
K
K
P
Site 165
S912
N
S
L
F
T
S
A
S
S
S
K
K
P
K
A
Site 166
S914
L
F
T
S
A
S
S
S
K
K
P
K
A
D
S
Site 167
S921
S
K
K
P
K
A
D
S
Q
L
Q
P
H
G
G
Site 168
T931
Q
P
H
G
G
D
L
T
K
A
A
H
N
N
S
Site 169
S938
T
K
A
A
H
N
N
S
E
N
I
P
L
H
K
Site 170
S946
E
N
I
P
L
H
K
S
R
P
Q
T
K
P
W
Site 171
T950
L
H
K
S
R
P
Q
T
K
P
W
S
P
G
S
Site 172
S954
R
P
Q
T
K
P
W
S
P
G
S
N
G
H
R
Site 173
S957
T
K
P
W
S
P
G
S
N
G
H
R
D
C
K
Site 174
Y979
D
M
P
R
S
A
D
Y
F
M
Q
E
A
K
R
Site 175
S1027
Q
G
P
M
E
S
K
S
P
Y
T
M
Y
S
E
Site 176
Y1029
P
M
E
S
K
S
P
Y
T
M
Y
S
E
T
V
Site 177
S1033
K
S
P
Y
T
M
Y
S
E
T
V
E
L
I
R
Site 178
Y1041
E
T
V
E
L
I
R
Y
A
M
R
L
K
T
H
Site 179
T1047
R
Y
A
M
R
L
K
T
H
S
G
P
N
A
T
Site 180
S1049
A
M
R
L
K
T
H
S
G
P
N
A
T
P
E
Site 181
T1054
T
H
S
G
P
N
A
T
P
E
D
K
Q
L
A
Site 182
Y1086
K
R
D
H
A
V
K
Y
S
K
A
L
I
D
Y
Site 183
Y1093
Y
S
K
A
L
I
D
Y
F
K
N
S
S
K
A
Site 184
S1105
S
K
A
A
Q
A
P
S
P
W
G
A
S
G
K
Site 185
S1110
A
P
S
P
W
G
A
S
G
K
S
T
G
T
P
Site 186
S1113
P
W
G
A
S
G
K
S
T
G
T
P
S
P
M
Site 187
T1114
W
G
A
S
G
K
S
T
G
T
P
S
P
M
S
Site 188
T1116
A
S
G
K
S
T
G
T
P
S
P
M
S
P
N
Site 189
S1118
G
K
S
T
G
T
P
S
P
M
S
P
N
P
S
Site 190
S1121
T
G
T
P
S
P
M
S
P
N
P
S
P
A
S
Site 191
S1125
S
P
M
S
P
N
P
S
P
A
S
S
V
G
S
Site 192
S1128
S
P
N
P
S
P
A
S
S
V
G
S
Q
G
S
Site 193
S1129
P
N
P
S
P
A
S
S
V
G
S
Q
G
S
L
Site 194
S1132
S
P
A
S
S
V
G
S
Q
G
S
L
S
N
A
Site 195
S1135
S
S
V
G
S
Q
G
S
L
S
N
A
S
A
L
Site 196
S1137
V
G
S
Q
G
S
L
S
N
A
S
A
L
S
P
Site 197
S1140
Q
G
S
L
S
N
A
S
A
L
S
P
S
T
I
Site 198
S1149
L
S
P
S
T
I
V
S
I
P
Q
R
I
H
Q
Site 199
T1165
A
A
N
H
V
S
I
T
N
S
I
L
H
S
Y
Site 200
Y1172
T
N
S
I
L
H
S
Y
D
Y
W
E
M
A
D
Site 201
Y1174
S
I
L
H
S
Y
D
Y
W
E
M
A
D
N
L
Site 202
T1200
D
L
L
M
G
P
V
T
L
H
S
S
M
E
H
Site 203
Y1211
S
M
E
H
L
V
Q
Y
S
Q
Q
G
L
H
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation